| General Information |
| MoonProt ID | 507 |
| First appeared in release | 3.0 |
| Name(s) | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
Gene: PLCB1 Synonyms: KIAA0581
Recommended name:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (EC:3.1.4.11)
Alternative name(s):
PLC-154
Phosphoinositide phospholipase C-beta-1
Phospholipase C-I
Short name:
PLC-I
Phospholipase C-beta-1
Short name:
PLC-beta-1 |
| UniProt ID | Q9NQ66 (PLCB1_HUMAN) |
| GO terms | GO:0004435 phosphatidylinositol phospholipase C activity
GO:0046488 phosphatidylinositol metabolic process
GO:0019899 enzyme binding
GO:0007165 signal transduction
GO:0016787 hydrolase activity
GO:0016020 membrane
GO:0006629 lipid metabolic process
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0031965 nuclear membrane
GO:0070062 extracellular exosome |
| Organisms for which functions have been demonstrated | Homo sapiens (Human) |
| Sequence length | 1216 amino acids |
| FASTA sequence | >sp|Q9NQ66|PLCB1_HUMAN 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 OS=Homo sapiens OX=9606 GN=PLCB1 PE=1 SV=1
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGRHAKAPKDPKLRELLDVGNIGRLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSADRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPTLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNERNQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKKEADPGETPSEAPSEARTTPAENGVNHTTTLTPKPPSQALHSQPAPGSVKAPAKTEDLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKPKLQVELEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHGSAPLSLSSDPGKVNHKTPSSEELGGDIPGKEFDTPL |
| Structure Information |
| PDB ID | NA |
| Quaternary structure | NA |
| SCOP | |
| CATH | |
| TM Helix Prediction | no TM helices
no TM helices
# sp|Q9NQ66|PLCB1_HUMAN Exp number of AAs in TMHs: 0.00095
# sp|Q9NQ66|PLCB1_HUMAN Exp number, first 60 AAs: 0.00018
# sp|Q9NQ66|PLCB1_HUMAN Total prob of N-in: 0.00005
sp|Q9NQ66|PLCB1_HUMAN TMHMM2.0 outside 1 1216 |
| DisProt Annotation | |
| Predicted Disorder Regions | Use FASTA sequence on the MFDp2 webserver.
spQ9NQ66PLCB1_HUMAN_1pho is 1216 residues long, with 387 residues (31.83 %) predicted as disordered. The protein has 1 short (< 30 residues) disorder segment and 4 long (>= 30 residues) disorder segments.
Segment 1 - Short (< 30 residues) disordered segment
Segment is located between positions 1 and 11 in the sequence.
The segment is 11 residues long (0.90 % of the total sequence length).
Segment 2 - Long (>= 30 residues) disordered segment
Segment is located between positions 462 and 534 in the sequence.
The segment is 73 residues long (6.00 % of the total sequence length).
Segment 3 - Long (>= 30 residues) disordered segment
Segment is located between positions 821 and 1008 in the sequence.
The segment is 188 residues long (15.46 % of the total sequence length).
Segment 4 - Long (>= 30 residues) disordered segment
Segment is located between positions 1058 and 1110 in the sequence.
The segment is 53 residues long (4.36 % of the total sequence length).
Segment 5 - Long (>= 30 residues) disordered segment
Segment is located between positions 1155 and 1216 in the sequence.
The segment is 62 residues long (5.10 % of the total sequence length). |
| Connections to Disease |
| OMIM ID | 607120 |
| Function 1 |
| Function description | phospholipase |
| References for function | Jackson L, Qifti A, Pearce KM, Scarlata S. Regulation of bifunctional proteins in cells: Lessons from the phospholipase C beta/G protein pathway. Protein Sci. 2020 Jun;29(6):1258-1268. doi: 10.1002/pro.3809. Epub 2019 Dec 31. PMID: 31867822; PMCID: PMC7255524. |
| E.C. number | 3.1.4.11 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm membrane |
| Comments | |
| Function 2 |
| Function description | inhibit protein translation |
| References for function | Jackson L, Qifti A, Pearce KM, Scarlata S. Regulation of bifunctional proteins in cells: Lessons from the phospholipase C beta/G protein pathway. Protein Sci. 2020 Jun;29(6):1258-1268. doi: 10.1002/pro.3809. Epub 2019 Dec 31. PMID: 31867822; PMCID: PMC7255524. |
| E.C. number | |
| Location of functional site(s) | cytosol |
| Cellular location of function | |
| Comments | |