| General Information |
| MoonProt ID | 508 |
| First appeared in release | 3.0 |
| Name(s) | Serine/threonine-protein kinase LATS1
Gene:LATS1 Synonyms:WARTS
Recommended name:
Serine/threonine-protein kinase LATS1 (EC:2.7.11.1)
Alternative name(s):
Large tumor suppressor homolog 1
WARTS protein kinase
Short name:
h-warts |
| UniProt ID | O95835 (LATS1_HUMAN) |
| GO terms | GO:0019901 protein kinase binding
GO:0005515 protein binding
GO:0060644 mammary gland epithelial cell differentiation
GO:0030331 estrogen receptor binding
GO:0033146 regulation of intracellular estrogen receptor signaling pathway
GO:2000058 regulation of ubiquitin-dependent protein catabolic process
GO:0046872 metal ion binding
GO:0016740 transferase activity
GO:0051301 cell division
GO:0016301 kinase activity
GO:0005524 ATP binding
GO:0000166 nucleotide binding
GO:0007049 cell cycle
GO:0004674 protein serine/threonine kinase activity
GO:0005856 cytoskeleton
GO:0005737 cytoplasm
GO:0016310 phosphorylation
GO:0005815 microtubule organizing center
GO:0000287 magnesium ion binding
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000819 sister chromatid segregation
GO:0000086 G2/M transition of mitotic cell cycle
GO:0009755 hormone-mediated signaling pathway
GO:0030833 regulation of actin filament polymerization
GO:0006468 protein phosphorylation
GO:0000922 spindle pole |
| Organisms for which functions have been demonstrated | Homo sapiens (Human) |
| Sequence length | 1130 amino acids |
| FASTA sequence | >sp|O95835|LATS1_HUMAN Serine/threonine-protein kinase LATS1 OS=Homo sapiens OX=9606 GN=LATS1 PE=1 SV=1
MKRSEKPEGYRQMRPKTFPASNYTVSSRQMLQEIRESLRNLSKPSDAAKAEHNMSKMSTEDPRQVRNPPKFGTHHKALQEIRNSLLPFANETNSSRSTSEVNPQMLQDLQAAGFDEDMVIQALQKTNNRSIEAAIEFISKMSYQDPRREQMAAAAARPINASMKPGNVQQSVNRKQSWKGSKESLVPQRHGPPLGESVAYHSESPNSQTDVGRPLSGSGISAFVQAHPSNGQRVNPPPPPQVRSVTPPPPPRGQTPPPRGTTPPPPSWEPNSQTKRYSGNMEYVISRISPVPPGAWQEGYPPPPLNTSPMNPPNQGQRGISSVPVGRQPIIMQSSSKFNFPSGRPGMQNGTGQTDFMIHQNVVPAGTVNRQPPPPYPLTAANGQSPSALQTGGSAAPSSYTNGSIPQSMMVPNRNSHNMELYNISVPGLQTNWPQSSSAPAQSSPSSGHEIPTWQPNIPVRSNSFNNPLGNRASHSANSQPSATTVTAITPAPIQQPVKSMRVLKPELQTALAPTHPSWIPQPIQTVQPSPFPEGTASNVTVMPPVAEAPNYQGPPPPYPKHLLHQNPSVPPYESISKPSKEDQPSLPKEDESEKSYENVDSGDKEKKQITTSPITVRKNKKDEERRESRIQSYSPQAFKFFMEQHVENVLKSHQQRLHRKKQLENEMMRVGLSQDAQDQMRKMLCQKESNYIRLKRAKMDKSMFVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSSCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKNGADEIKAHPFFKTIDFSSDLRQQSASYIPKITHPTDTSNFDPVDPDKLWSDDNEEENVNDTLNGWYKNGKHPEHAFYEFTFRRFFDDNGYPYNYPKPIEYEYINSQGSEQQSDEDDQNTGSEIKNRDLVYV |
| Structure Information |
| PDB ID | 4ZRK
5B5W
5BRK |
| Quaternary structure | NA |
| SCOP | 3 domains.
Domain 1.
class 1000000 All alpha proteins
fold 2000757 Acyl-CoA binding protein-like
superfamily 3001227 FERM central domain-like
domain 8039700 This domain is represented by 1ISN A:104-214 Merlin. Species Mus musculus.
Domain 2.
class 1000001 All beta proteins
fold 2000118 PH domain-like beta(6)-barrel
superfamily 3000134 PH domain-like
domain 8039701 This domain is represented by 1ISN A:215-340 Merlin Species Mus musculus.
Domain 3.
class 1000003 Alpha and beta proteins (a+b)
fold 2000097 beta-Grasp
superfamily 3000157 Ubiquitin-like
domain 8039704 This domain is represented by 1ISN A:18-103 Merlin Species Mus musculus. |
| CATH | 1 Matching CATH Superfamily.
Superfamily: 1.20.140.30 Mob1/phocein.
1 Matching CATH Domains
Domain: 5b5wA00 PDB code 5b5w, chain A, domain 00 Superfamily: 1.20.140.30. |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | |
| Predicted Disorder Regions | Use FASTA sequence on the MFDp2 webserver.
spO95835LATS1_HUMAN_Seri is 1130 residues long, with 612 residues (54.16 %) predicted as disordered. The protein has 1 short (< 30 residues) disorder segment and 3 long (>= 30 residues) disorder segments.
Segment 1 - Long (>= 30 residues) disordered segment
Segment is located between positions 1 and 78 in the sequence.
The segment is 78 residues long (6.90 % of the total sequence length).
Segment 2 - Long (>= 30 residues) disordered segment
Segment is located between positions 154 and 636 in the sequence.
The segment is 483 residues long (42.74 % of the total sequence length).
Segment 3 - Short (< 30 residues) disordered segment
Segment is located between positions 1053 and 1062 in the sequence.
The segment is 10 residues long (0.88 % of the total sequence length).
Segment 4 - Long (>= 30 residues) disordered segment
Segment is located between positions 1090 and 1130 in the sequence.
The segment is 41 residues long (3.63 % of the total sequence length). |
| Connections to Disease |
| OMIM ID | 603473 |
| Function 1 |
| Function description | kinase |
| References for function | Nishiyama Y, Hirota T, Morisaki T, Hara T, Marumoto T, Iida S, Makino K, Yamamoto H, Hiraoka T, Kitamura N, Saya H. A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis. FEBS Lett. 1999 Oct 8;459(2):159-65. doi: 10.1016/s0014-5793(99)01224-7. PMID: 10518011. |
| E.C. number | 2.7.11.1 |
| Location of functional site(s) | |
| Cellular location of function | centrosome |
| Comments | |
| Function 2 |
| Function description | scaffold function. |
| References for function | Tang F, Gao R, Jeevan-Raj B, Wyss CB, Kalathur RKR, Piscuoglio S, Ng CKY, Hindupur SK, Nuciforo S, Dazert E, Bock T, Song S, Buechel D, Morini MF, Hergovich A, Matthias P, Lim DS, Terracciano LM, Heim MH, Hall MN, Christofori G. LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function. Nat Commun. 2019 Dec 17;10(1):5755. doi: 10.1038/s41467-019-13591-7. PMID: 31848340; PMCID: PMC6917744. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | |
| Comments | |