Protein Information

General Information
MoonProt ID509
First appeared in release3.0
Name(s)Interleukin-1 alpha Gene: IL1A Synonyms:IL1F1 Recommended name: Interleukin-1 alpha Short name: IL-1 alpha Alternative name(s): Hematopoietin-1
UniProt IDP01583 (IL1A_HUMAN)
GO termsGO:0046688 response to copper ion GO:0034605 cellular response to heat GO:0005829 cytosol GO:0005615 extracellular space GO:0005507 copper ion binding GO:0005515 protein binding GO:0005125 cytokine activity GO:0051781 positive regulation of cell division GO:0001660 fever generation GO:0005737 cytoplasm GO:0006954 inflammatory response GO:0005576 extracellular region GO:0010628 positive regulation of gene expression
Organisms for which functions have been demonstratedHomo sapiens (Human)
Sequence length271 amino acids
Structure Information
Quaternary structureNA
SCOP1 domian. class 1000001 All beta proteins fold 2000422 beta-Trefoil superfamily 3000648 Cytokine family 4001996 Interleukin-1 (IL-1) domain 8029639 2ILA A:5-152 Interleukin-1 alpha. Species Homo sapiens.
CATH2 Matching CATH Superfamilies. Superfamily: EF-hand. Superfamily: CATH superfamily 4 Matching CATH Domains. Domain: 2l5xA00. PDB code 2l5x, chain A, domain 00. Superfamily: Domain: 2l5xB00. PDB code 2l5x, chain B, domain 00. Superfamily: Domain: 2l5xC00. PDB code 2l5x, chain C, domain 00. Superfamily: Domain: 2l5xD00. PDB code 2l5x, chain D, domain 00. Superfamily:
TM Helix Predictionno TM helices # sp|P01583|IL1A_HUMAN Number of predicted TMHs: 0 # sp|P01583|IL1A_HUMAN Exp number of AAs in TMHs: 0.0016 # sp|P01583|IL1A_HUMAN Exp number, first 60 AAs: 0 # sp|P01583|IL1A_HUMAN Total prob of N-in: 0.02364 sp|P01583|IL1A_HUMAN TMHMM2.0 outside 1 271
DisProt Annotation
Predicted Disorder RegionsUse FASTA sequence on the MFDp2 webserver. spP01583IL1A_HUMAN_Inter is 271 residues long, with 6 residues (2.21 %) predicted as disordered. The protein has 1 short (< 30 residues) disorder segment and 0 long (>= 30 residues) disorder segments. Segment 1 - Short (< 30 residues) disordered segment Segment is located between positions 1 and 6 in the sequence. The segment is 6 residues long (2.21 % of the total sequence length).
Connections to Disease
OMIM ID147760
Function 1
Function descriptionbinds receptor, A cytokine of the interleukin 1 family. It can stimulate thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity.
References for functionZsebo KM, Wypych J, Yuschenkoff VN, Lu H, Hunt P, Dukes PP, Langley KE. Effects of hematopoietin-1 and interleukin 1 activities on early hematopoietic cells of the bone marrow. Blood. 1988 Apr;71(4):962-8. PMID: 3281727. March CJ, Mosley B, Larsen A, Cerretti DP, Braedt G, Price V, Gillis S, Henney CS, Kronheim SR, Grabstein K, et al. Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. Nature. 1985 Jun 20-26;315(6021):641-7. doi:10.1038/315641a0. PMID: 2989698.
E.C. number
Location of functional site(s)
Cellular location of functionsecreted
Function 2
Function descriptionRegulation of transcription. The precursor form of IL-1 alphais an intracrine proinflammatory activator of transcription.
References for functionWerman A, Werman Venkert R, White R, Lee JK, Werman B, Krelin Y, Voronov E, Dinarello CA, Apte RN. The precursor form of IL 1alpha is an intracrine proinflammatory activator of transcription. Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2434-9. doi: 10.1073/pnas.0308705101. PMID: 14983027; PMCID: PMC356968.
E.C. number
Location of functional site(s)
Cellular location of function