| General Information |
| MoonProt ID | 509 |
| First appeared in release | 3.0 |
| Name(s) | Interleukin-1 alpha
Gene: IL1A Synonyms:IL1F1
Recommended name:
Interleukin-1 alpha
Short name:
IL-1 alpha
Alternative name(s):
Hematopoietin-1 |
| UniProt ID | P01583 (IL1A_HUMAN) |
| GO terms | GO:0046688 response to copper ion
GO:0034605 cellular response to heat
GO:0005829 cytosol
GO:0005615 extracellular space
GO:0005507 copper ion binding
GO:0005515 protein binding
GO:0005125 cytokine activity
GO:0051781 positive regulation of cell division
GO:0001660 fever generation
GO:0005737 cytoplasm
GO:0006954 inflammatory response
GO:0005576 extracellular region
GO:0010628 positive regulation of gene expression |
| Organisms for which functions have been demonstrated | Homo sapiens (Human) |
| Sequence length | 271 amino acids |
| FASTA sequence | >sp|P01583|IL1A_HUMAN Interleukin-1 alpha OS=Homo sapiens OX=9606 GN=IL1A PE=1 SV=1
MAKVPDMFEDLKNCYSENEEDSSSIDHLSLNQKSFYHVSYGPLHEGCMDQSVSLSISETSKTSKLTFKESMVVVATNGKVLKKRRLSLSQSITDDDLEAIANDSEEEIIKPRSAPFSFLSNVKYNFMRIIKYEFILNDALNQSIIRANDQYLTAAALHNLDEAVKFDMGAYKSSKDDAKITVILRISKTQLYVTAQDEDQPVLLKEMPEIPKTITGSETNLLFFWETHGTKNYFTSVAHPNLFIATKQDYWVCLAGGPPSITDFQILENQA |
| Structure Information |
| PDB ID | 1ITA
2ILA
2KKI
2L5X
5UC6 |
| Quaternary structure | NA |
| SCOP | 1 domian.
class 1000001 All beta proteins
fold 2000422 beta-Trefoil
superfamily 3000648 Cytokine
family 4001996 Interleukin-1 (IL-1)
domain 8029639 2ILA A:5-152 Interleukin-1 alpha. Species Homo sapiens. |
| CATH | 2 Matching CATH Superfamilies.
Superfamily: 1.10.238.10 EF-hand.
Superfamily: 2.80.10.50 CATH superfamily 2.80.10.50.
4 Matching CATH Domains.
Domain: 2l5xA00. PDB code 2l5x, chain A, domain 00. Superfamily: 2.80.10.50.
Domain: 2l5xB00. PDB code 2l5x, chain B, domain 00. Superfamily: 1.10.238.10.
Domain: 2l5xC00. PDB code 2l5x, chain C, domain 00. Superfamily: 1.10.238.10.
Domain: 2l5xD00. PDB code 2l5x, chain D, domain 00. Superfamily: 2.80.10.50. |
| TM Helix Prediction | no TM helices
# sp|P01583|IL1A_HUMAN Number of predicted TMHs: 0
# sp|P01583|IL1A_HUMAN Exp number of AAs in TMHs: 0.0016
# sp|P01583|IL1A_HUMAN Exp number, first 60 AAs: 0
# sp|P01583|IL1A_HUMAN Total prob of N-in: 0.02364
sp|P01583|IL1A_HUMAN TMHMM2.0 outside 1 271 |
| DisProt Annotation | |
| Predicted Disorder Regions | Use FASTA sequence on the MFDp2 webserver.
spP01583IL1A_HUMAN_Inter is 271 residues long, with 6 residues (2.21 %) predicted as disordered. The protein has 1 short (< 30 residues) disorder segment and 0 long (>= 30 residues) disorder segments.
Segment 1 - Short (< 30 residues) disordered segment
Segment is located between positions 1 and 6 in the sequence.
The segment is 6 residues long (2.21 % of the total sequence length). |
| Connections to Disease |
| OMIM ID | 147760 |
| Function 1 |
| Function description | binds receptor, A cytokine of the interleukin 1 family. It can stimulate thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. |
| References for function | Zsebo KM, Wypych J, Yuschenkoff VN, Lu H, Hunt P, Dukes PP, Langley KE. Effects of hematopoietin-1 and interleukin 1 activities on early hematopoietic cells of the bone marrow. Blood. 1988 Apr;71(4):962-8. PMID: 3281727.
March CJ, Mosley B, Larsen A, Cerretti DP, Braedt G, Price V, Gillis S, Henney CS, Kronheim SR, Grabstein K, et al. Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. Nature. 1985 Jun 20-26;315(6021):641-7. doi:10.1038/315641a0. PMID: 2989698. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | secreted |
| Comments | |
| Function 2 |
| Function description | Regulation of transcription. The precursor form of IL-1 alphais an intracrine proinflammatory activator of transcription. |
| References for function | Werman A, Werman Venkert R, White R, Lee JK, Werman B, Krelin Y, Voronov E, Dinarello CA, Apte RN. The precursor form of IL 1alpha is an intracrine proinflammatory activator of transcription. Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2434-9. doi: 10.1073/pnas.0308705101. PMID: 14983027; PMCID: PMC356968. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | |
| Comments | |