General Information |
MoonProt ID | 510 |
First appeared in release | 3.0 |
Name(s) | Fibroblast growth factor 1
Gene:FGF1 Synonyms:FGFA
Recommended name:
Fibroblast growth factor 1
Short name:
FGF-1
Alternative name(s):
Acidic fibroblast growth factor
Short name:
aFGF
Endothelial cell growth factor
Short name:
ECGF
Heparin-binding growth factor 1
Short name:
HBGF-1 |
UniProt ID | P05230 (FGF1_HUMAN) |
GO terms | GO:0045766 positive regulation of angiogenesis
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0008201 heparin binding
GO:0008083 growth factor activity
GO:0051781 positive regulation of cell division
GO:0034605 cellular response to heat
GO:0030335 positive regulation of cell migration
GO:0005829 cytosol
GO:0005615 extracellular space
GO:0005576 extracellular region
GO:0005178 integrin binding
GO:0005104 fibroblast growth factor receptor binding
GO:0032148 activation of protein kinase B activity
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0008201 heparin binding
GO:1903672 positive regulation of sprouting angiogenesis
GO:0000187 activation of MAPK activity
GO:0030335 positive regulation of cell migration
GO:0008284 positive regulation of cell population proliferation
GO:1901509 regulation of endothelial tube morphogenesis
GO:0010595 positive regulation of endothelial cell migration
GO:0001525 angiogenesis
GO:0030154 cell differentiation
GO:0051781 positive regulation of cell division
GO:0008083 growth factor activity
GO:0007275 multicellular organism development
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005938 cell cortex
GO:0043406 positive regulation of MAP kinase activity
GO:0044548 S100 protein binding
GO:2000544 regulation of endothelial cell chemotaxis to fibroblast growth factor
GO:0060681 branch elongation involved in ureteric bud branching
GO:0042060 wound healing
GO:0072163 mesonephric epithelium development |
Organisms for which functions have been demonstrated | Homo sapiens (Human) |
Sequence length | 155 amino acids |
FASTA sequence | >sp|P05230|FGF1_HUMAN Fibroblast growth factor 1 OS=Homo sapiens OX=9606 GN=FGF1 PE=1 SV=1
MAEGEITTFTALTEKFNLPPGNYKKPKLLYCSNGGHFLRILPDGTVDGTRDRSDQHIQLQLSAESVGEVYIKSTETGQYLAMDTDGLLYGSQTPNEECLFLERLEENHYNTYISKKHAEKNWFVGLKKNGSCKRGPRTHYGQKAILFLPLPVSSD |
Structure Information |
PDB ID | 1AXM
1DJS
1DZC
1DZD
1E0O
1EVT
1HKN
1JQZ
1JT3
1JT4
1JT5
1JT7
1JTC
1JY0
1K5U
1K5V
1M16
1NZK
1P63
1PZZ
1Q03
1Q04
1QCT
1RG8
1RML
1RY7
1YTO
1Z2V
1Z4S
2AFG
2AQZ
2AXM
2ERM
2HW9
2HWA
2HWM
2HZ9
2K43
2K4A
2K8R
2KI4
2KI6
2NTD
2Q9X
2RQ9
3B9U
3BA4
3BA5
3BA7
3BAD
3BAG
3BAH
3BAO
3BAQ
3BAU
3BAV
3BB2
3CQA
3CRG
3CRH
3CRI
3CU1
3FGM
3FJ8
3FJ9
3FJA
3FJB
3FJC
3FJD
3FJE
3FJF
3FJH
3FJI
3FJJ
3FJK
3HOM
3JUT
3K1X
3O3Q
3OJ2
3OJM
3OJV
3UD7
3UD8
3UD9
3UDA
4J23
4Q91
4Q9G
4Q9P
4QAL
4QBC
4QBV
4QC4
4QO3
4XKI
4YOL |
Quaternary structure | NA |
SCOP | 1 domain.
class 1000001 All beta proteins
fold 2000422 beta-Trefoil
superfamily 3000648 Cytokine
family 4001987 Fibroblast growth factors (FGF)
domain 8029860 This domain is represented by 1RG8 A:1-137 Fibroblast growth factor 1. Species Homo sapiens. |
CATH | 2 Matching CATH Superfamilies.
Superfamily: 2.60.40.10 Immunoglobulins.
Superfamily: 2.80.10.50 CATH superfamily 2.80.10.50.
3 Matching CATH Domains.
Domain: 1djsA01. PDB code 1djs, chain A, domain 01. Superfamily: 2.60.40.10.
Domain: 1djsA02. PDB code 1djs, chain A, domain 02. Superfamily: 2.60.40.10.
Domain: 1djsB00. PDB code 1djs, chain B, domain 00. Superfamily: 2.80.10.50. |
TM Helix Prediction | no TM helices
# sp|P05230|FGF1_HUMAN Number of predicted TMHs: 0
# sp|P05230|FGF1_HUMAN Exp number of AAs in TMHs: 0.00033
# sp|P05230|FGF1_HUMAN Exp number, first 60 AAs: 0
# sp|P05230|FGF1_HUMAN Total prob of N-in: 0.11036
sp|P05230|FGF1_HUMAN TMHMM2.0 outside 1 155 |
DisProt Annotation | |
Predicted Disorder Regions | Use FASTA sequence on the MFDp2 webserver.
spP05230FGF1_HUMAN_Fibro is 155 residues long, with 36 residues (23.23 %) predicted as disordered. The protein has 2 short (< 30 residues) disorder segments and 0 long (>= 30 residues) disorder segments.
Segment 1 - Short (< 30 residues) disordered segment
Segment is located between positions 1 and 15 in the sequence.
The segment is 15 residues long (9.68 % of the total sequence length).
Segment 2 - Short (< 30 residues) disordered segment
Segment is located between positions 135 and 155 in the sequence.
The segment is 21 residues long (13.55 % of the total sequence length). |
Connections to Disease |
OMIM ID | 131220 |
Function 1 |
Function description | growth factor |
References for function | Ornitz DM, Xu J, Colvin JS, McEwen DG, MacArthur CA, Coulier F, Gao G, Goldfarb M. Receptor specificity of the fibroblast growth factor family. J Biol Chem. 1996 Jun 21;271(25):15292-7. doi: 10.1074/jbc.271.25.15292. PMID: 8663044. |
E.C. number | |
Location of functional site(s) | |
Cellular location of function | secreted |
Comments | |
Function 2 |
Function description | nuclear anti-apoptotic factor |
References for function | Delmas E, Jah N, Pirou C, Bouleau S, Le Floch N, Vayssière JL, Mignotte B, Renaud F. FGF1 C-terminal domain and phosphorylation regulate intracrine FGF1 signaling for its neurotrophic and anti-apoptotic activities. Cell Death Dis. 2016 Feb 4;7(2):e2079. doi: 10.1038/cddis.2016.2. PMID: 26844696; PMCID: PMC4849156. |
E.C. number | |
Location of functional site(s) | |
Cellular location of function | nucleus |
Comments | |