General Information |
MoonProt ID | 512 |
First appeared in release | 3.0 |
Name(s) | High mobility group protein B1
Gene:HMGB1 Synonyms:HMG1
Recommended name:
High mobility group protein B1
Alternative name(s):
High mobility group protein 1
Short name:
HMG-1 |
UniProt ID | P09429 (HMGB1_HUMAN) |
GO terms | GO:0043277 apoptotic cell clearance
GO:0032689 negative regulation of interferon-gamma production
GO:0003684 damaged DNA binding
GO:0070182 DNA polymerase binding
GO:0090026 positive regulation of monocyte chemotaxis
GO:0019958 C-X-C chemokine binding
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0002218 activation of innate immune response
GO:0001530 lipopolysaccharide binding
GO:1990774 tumor necrosis factor secretion
GO:0043410 positive regulation of MAPK cascade
GO:0046330 positive regulation of JNK cascade
GO:0032425 positive regulation of mismatch repair
GO:0045063 T-helper 1 cell differentiation
GO:0032735 positive regulation of interleukin-12 production
GO:0042104 positive regulation of activated T cell proliferation
GO:0002840 regulation of T cell mediated immune response to tumor cell
GO:0034165 positive regulation of toll-like receptor 9 signaling pathway
GO:0097350 neutrophil clearance
GO:0001786 phosphatidylserine binding
GO:0043371 negative regulation of CD4-positive, alpha-beta T cell differentiation
GO:0035711 T-helper 1 cell activation
GO:0032733 positive regulation of interleukin-10 production
GO:0016829 lyase activity
GO:0032072 regulation of restriction endodeoxyribonuclease activity
GO:0032732 positive regulation of interleukin-1 production
GO:0032755 positive regulation of interleukin-6 production
GO:0002643 regulation of tolerance induction
GO:0051106 positive regulation of DNA ligation
GO:2001200 positive regulation of dendritic cell differentiation
GO:0010508 positive regulation of autophagy
GO:0005576 extracellular region
GO:0002376 immune system process
GO:0006281 DNA repair
GO:0045087 innate immune response
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0006954 inflammatory response
GO:0003677 DNA binding
GO:0006974 cellular response to DNA damage stimulus
GO:0016020 membrane
GO:0006935 chemotaxis
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005634 nucleus
GO:0006914 autophagy
GO:0002250 adaptive immune response
GO:0006310 DNA recombination
GO:0016032 viral process
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0003713 transcription coactivator activity
GO:0050786 RAGE receptor binding
GO:0005125 cytokine activity
GO:0003690 double-stranded DNA binding
GO:0070491 repressing transcription factor binding
GO:0003723 RNA binding
GO:0042056 chemoattractant activity
GO:0008301 DNA binding, bending
GO:0008134 transcription factor binding
GO:0005515 protein binding
GO:0003697 single-stranded DNA binding
GO:0043388 positive regulation of DNA binding
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0033151 V(D)J recombination
GO:0006357 regulation of transcription by RNA polymerase II
GO:0005615 extracellular space
GO:0031175 neuron projection development
GO:0002437 inflammatory response to antigenic stimulus
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0043065 positive regulation of apoptotic process
GO:0017055 negative regulation of RNA polymerase II transcription preinitiation complex assembly
GO:0017053 transcription repressor complex
GO:0009986 cell surface
GO:0000793 condensed chromosome
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0006342 chromatin silencing
GO:0051103 DNA ligation involved in DNA repair
GO:0006265 DNA topological change
GO:0002407 dendritic cell chemotaxis
GO:0001773 myeloid dendritic cell activation |
Organisms for which functions have been demonstrated | Homo sapiens (Human) |
Sequence length | 215 amino acids |
FASTA sequence | >sp|P09429|HMGB1_HUMAN High mobility group protein B1 OS=Homo sapiens OX=9606 GN=HMGB1 PE=1 SV=3
MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE |
Structure Information |
PDB ID | 2LY4
2RTU
2YRQ
6CG0
6CIJ
6CIK
6CIL
6CIM
6OEM
6OEN
6OEO |
Quaternary structure | NA |
SCOP | 1 domain.
class 1000004 Small proteins
fold 2001271 Helical binder
superfamily 3002701 p53 TAD
family 4007136 p53 transactivation domain (TAD)
domain 8050972 This domain is represented by 3DAC P:17-28 Cellular tumor antigen p53 Species Homo sapiens. |
CATH | 1 Matching CATH Superfamily.
Superfamily: 1.10.30.10 DNA Binding (I), subunit A.
1 Matching CATH Domain.
Domain: PDB code 2ly4, chain A, domain 00 Superfamily: 1.10.30.10. |
TM Helix Prediction | no TM helices |
DisProt Annotation | DisProt ID: DP01493
UniProt Accession: P09429
Protein Name: High mobility group protein B1
Organism: Homo sapiens
Disorder content: 0.2 |
Predicted Disorder Regions | Use FASTA sequence on the MFDp2 webserver.
spP09429HMGB1_HUMAN_High is 215 residues long, with 215 residues (100.00 %) predicted as disordered. The protein has 0 short (< 30 residues) disorder segments and 1 long (>= 30 residues) disorder segment.
Segment 1 - Long (>= 30 residues) disordered segment
Segment is located between positions 1 and 215 in the sequence.
The segment is 215 residues long (100.00 % of the total sequence length). |
Connections to Disease |
OMIM ID | 163905 |
Function 1 |
Function description | One of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. |
References for function | Li G, Liang X, Lotze MT. HMGB1: The Central Cytokine for All Lymphoid Cells. Front Immunol. 2013 Mar 20;4:68. doi: 10.3389/fimmu.2013.00068. PMID: 23519706; PMCID: PMC3602962.
Thomas JO. HMG1 and 2: architectural DNA-binding proteins. Biochem Soc Trans. 2001 Aug;29(Pt 4):395-401. doi: 10.1042/bst0290395. PMID: 11497996. |
E.C. number | |
Location of functional site(s) | |
Cellular location of function | nucleus |
Comments | |
Function 2 |
Function description | In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. |
References for function | Ivanov S, Dragoi AM, Wang X, Dallacosta C, Louten J, Musco G, Sitia G, Yap GS, Wan Y, Biron CA, Bianchi ME, Wang H, Chu WM. A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA. Blood. 2007 Sep 15;110(6):1970-81. doi: 10.1182/blood-2006-09-044776. Epub 2007 Jun 4. PMID: 17548579; PMCID: PMC1976374.
Tang D, Kang R, Livesey KM, Cheh CW, Farkas A, Loughran P, Hoppe G, Bianchi ME, Tracey KJ, Zeh HJ 3rd, Lotze MT. Endogenous HMGB1 regulates autophagy. J Cell Biol. 2010 Sep 6;190(5):881-92. doi: 10.1083/jcb.200911078. PMID: 20819940; PMCID: PMC2935581. |
E.C. number | |
Location of functional site(s) | |
Cellular location of function | cytosol |
Comments | |