| General Information |
| MoonProt ID | 536 |
| First appeared in release | 4.0 |
| Name(s) | Galectin |
| UniProt ID | Q9NGY1 |
| GO terms | "GO:0016936 galactoside binding
GO:0030246 carbohydrate binding" |
| Organisms for which functions have been demonstrated | Dirofilaria immitis |
| Sequence length | 281 |
| FASTA sequence | >tr|Q9NGY1|Q9NGY1_DIRIM Galectin OS=Dirofilaria immitis OX=6287 PE=2 SV=1 MHHNEYETNYQVPYRSKLTESFEPGQTLLVKGKTAEDSVRFTINLHNTSADFSGNDVPLHISVRFDEGKIVFNTFSKGEWGKEERKSNPYKKGDDIDIRIRAHDSKYTIYVDQKEVKEYEHRVPLSSVTHFSIDGDILVTYIHWGGKYYPVPYESGLIGEGLVPGKSLLIFATPEKKGKRFHINLLKKNGDIALHFNPRFDEKAIVRNSLIAGEWGNEEREGKMILEKGIGFDLEIKNEEYAFQIFINSERYATYAHRLDPHEINGLQIGGDLEVSGIQMH |
| Structure Information |
| PDB ID | NA |
| Quaternary structure | NA |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in Disprot |
| Predicted Disorder Regions | Disorder presdicted at amino acid residues 1-9 and 276-281 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | galectin |
| References for function | González-Miguel J, Morchón R, Carretón E, Montoya-Alonso JA, Simón F. Surface associated antigens of Dirofilaria immitis adult worms activate the host fibrinolytic system. Vet Parasitol. 2013 Sep 1;196(1-2):235-40. doi: 10.1016/j.vetpar.2013.01.028. Epub 2013 Feb 4. PMID: 23433649. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |
| Function 2 |
| Function description | bind plasminogen and stimulate plasmin generation by tissue plasminogen activator |
| References for function | González-Miguel J, Morchón R, Carretón E, Montoya-Alonso JA, Simón F. Surface associated antigens of Dirofilaria immitis adult worms activate the host fibrinolytic system. Vet Parasitol. 2013 Sep 1;196(1-2):235-40. doi: 10.1016/j.vetpar.2013.01.028. Epub 2013 Feb 4. PMID: 23433649. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |