| General Information |
| MoonProt ID | 545 |
| First appeared in release | 4.0 |
| Name(s) | Glutathione S-transferase A3 |
| UniProt ID | Q16772 |
| GO terms | "GO:0004364 glutathione transferase activity
GO:0016740 transferase activity
GO:0006629 lipid metabolic process
GO:0006749 glutathione metabolic process
GO:0006805 xenobiotic metabolic process
GO:0005829 cytosol
GO:0005737 cytoplasm
GO:0070062 extracellular exosome" |
| Organisms for which functions have been demonstrated | Homo sapiens (Human) |
| Sequence length | 222.0 |
| FASTA sequence | >sp|Q16772|GSTA3_HUMAN Glutathione S-transferase A3 OS=Homo sapiens OX=9606 GN=GSTA3 PE=1 SV=3 MAGKPKLHYFNGRGRMEPIRWLLAAAGVEFEEKFIGSAEDLGKLRNDGSLMFQQVPMVEI DGMKLVQTRAILNYIASKYNLYGKDIKERALIDMYTEGMADLNEMILLLPLCRPEEKDAK IALIKEKTKSRYFPAFEKVLQSHGQDYLVGNKLSRADISLVELLYYVEELDSSLISNFPL LKALKTRISNLPTVKKFLQPGSPRKPPADAKALEEARKIFRF |
| Structure Information |
| PDB ID | 1TDI 2VCV |
| Quaternary structure | Homodimer |
| SCOP | NA |
| CATH | 1.20.1050.10 |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | not in DisProt |
| Predicted Disorder Regions | Predicted disorder at N terminus (aa 1-7), and C terminus (aa 197-222) |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | enzyme, glutathione S-transferase |
| References for function | Mannervik B, Ismail A, Lindström H, Sjödin B, Ing NH. Glutathione Transferases as Efficient Ketosteroid Isomerases. Front Mol Biosci. 2021 Nov 22;8:765970. doi: 10.3389/fmolb.2021.765970. PMID: 34881290; PMCID: PMC8645602. |
| E.C. number | EC:2.5.1.18 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | enzyme, steroid isomerase |
| References for function | Mannervik B, Ismail A, Lindström H, Sjödin B, Ing NH. Glutathione Transferases as Efficient Ketosteroid Isomerases. Front Mol Biosci. 2021 Nov 22;8:765970. doi: 10.3389/fmolb.2021.765970. PMID: 34881290; PMCID: PMC8645602. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | |
| Comments | |