| General Information |
| MoonProt ID | 55 |
| First appeared in release | 1.0 |
| Name(s) | GAPDH
Glyceraldehyde-3-phosphate dehydrogenase |
| UniProt ID | Q27820 (Q27820_TRIVA), Unreviewed |
| GO terms | GO:0006006 glucose metabolic process
GO:0055114 oxidation-reduction process
GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0050661 NADP binding
GO:0051287 NAD binding |
| Organisms for which functions have been demonstrated | Trichomonas vaginalis |
| Sequence length | 350 |
| FASTA sequence | >gi|432487|gb|AAA30325.1| glyceraldehyde 3-phosphate dehydrogenase, partial [Trichomonas vaginalis]
RIGRLVFRACRKLYPKDIQVVAIHDLGDIKTNVYLLKYDTAHRAFPEPVTVDEAKQEFTVGEGADKWVVKSIGGRLGPSQLPWKELGIDVVLESTGIFRTKAEKDAEGKIKKDGYDGHLVSGAKKVVLSVPSADEIECTLVLGVNDEDLKPETKCISNASCTTNCLGPVAKTLNNAFGIRNGFMTTVHSYTNDQVVADTMHKDLRRARAAGMNIIPTSTGAAIALPKVCHGLPPKSLDGFALRVPTITGSLVDLTVNVNAKVTKEEVNAALKKATEEGSLKGIMTYVTDPIVSSDIIGCQYSSIVDALSTKVLPNPEGQGTLVKVLSWYDNEWMYSCRCADIFHRLEKYL
|
| Structure Information |
| PDB ID | closest is 51% amino acid sequence identity |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 349-350 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | Glyceraldehyde-3-phosphate dehydrogenase, enzyme |
| References for function | |
| E.C. number | 1.2.1.12 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | binds fibronectin
fibronectin binding, and plasminogen and collagen |
| References for function | Lama A, Kucknoor A, Mundodi V, Alderete JF. Glyceraldehyde-3-phosphate
dehydrogenase is a surface-associated, fibronectin-binding protein of
Trichomonas vaginalis. Infect Immun 2009, 77:2703-2711. PMID: 19380472 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |