| General Information |
| MoonProt ID | 56 |
| First appeared in release | 1.0 |
| Name(s) | GAPDH
Glyceraldehyde-3-phosphate dehydrogenase
Gene Name: gap |
| UniProt ID | Q6GIL8 |
| GO terms | GO:0006006 glucose metabolic process
GO:0055114 oxidation-reduction process
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0050661 NADP binding
GO:0051287 NAD binding |
| Organisms for which functions have been demonstrated | Staphylococcus aureus (S. epidermidis and S. aureus) (Gram positive bacteria) |
| Sequence length | 336 aa |
| FASTA sequence | >sp|Q6GIL8|G3P1_STAAR Glyceraldehyde-3-phosphate dehydrogenase 1 OS=Staphylococcus aureus (strain MRSA252) GN=gapA1 PE=1 SV=1
MAVKVAINGFGRIGRLAFRRIQEVEGLEVVAVNDLTDDDMLAHLLKYDTMQGRFTGEVEVVDGGFRVNGKEVKSFSEPDASKLPWKDLNIDVVLECTGFYTDKDKAQAHIEAGAKKVLISAPATGDLKTIVFNTNHQELDGSETVVSGASCTTNSLAPVAKVLNDDFGLVEGLMTTIHAYTGDQNTQDAPHRKGDKRRARAAAENIIPNSTGAAKAIGKVIPEIDGKLDGGAQRVPVATGSLTELTVVLEKQDVTVEQVNEAMKNASNESFGYTEDEIVSSDVVGMTYGSLFDATQTRVMSVGDRQLVKVAAWYDNEMSYTAQLVRTLAYLAELSK
|
| Structure Information |
| PDB ID | 3LVF
3VAZ 3LC7 3K73
3L6O
3LC2 3LC1
3HQ4
3KV3
3K9Q
3L4S
3KSD 3KSZ |
| Quaternary structure | |
| SCOP | NA |
| CATH | 3.40.50.720, 3.30.360.10 |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1,333-336 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | GAPDH, glyceraldehyde 3-phosphate dehydrogenase, enzyme |
| References for function | Modun, B., and Williams, P. (1999) The staphylococcal transferrin-binding protein is a cell wall glyceraldehyde-3- phosphate dehydrogenase. Infect Immun. 1999 Mar;67(3):1086-92.
PMID: 10024547 |
| E.C. number | 1.2.1.12 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | transferrin-binding protein (also called TPN) AND also binds plasminogen
involved in the acquisition of transferrin-bound iron |
| References for function | Modun, B., and Williams, P. (1999) The staphylococcal transferrin-binding protein is a cell wall glyceraldehyde-3- phosphate dehydrogenase. Infect Immun. 1999 Mar;67(3):1086-92.
PMID: 10024547 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |