| General Information |
| MoonProt ID | 576 |
| First appeared in release | 4.0 |
| Name(s) | Serine/threonine-protein kinase sel-5 |
| UniProt ID | G5ECQ3 |
| GO terms | GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0035612 AP-2 adaptor complex binding
GO:0046872 metal ion binding
GO:0106310 protein serine kinase activity
GO:0045747 positive regulation of Notch signaling pathway
GO:2000369 regulation of clathrin-dependent endocytosis
GO:0005737 cytoplasm |
| Organisms for which functions have been demonstrated | Caenorhabditis elegans |
| Sequence length | 1077 |
| FASTA sequence | >sp|G5ECQ3|SEL5_CAEEL Serine/threonine-protein kinase sel-5 OS=Caenorhabditis elegans OX=6239 GN=sel-5 PE=2 SV=1
MPLGLFSSGKAQVLCDEKIPGGKKKEPKQLSENKCKGVTLKLDHTRVTIEKQIAEGGFAIVYVASDRKNNKFALKRQFTKDNEKQLEACCREHSFLKQCIGHKNIVEFVDSYTNCLGNGIWECMLLTEYHQKNVLQLMNERISQNQYLTNDEILSIFTDLCEAVSFIHNRPQPIIHRDLKVENVLISSHKPPHYVLCDFGSATTQILSVEKYGVEYVKSEVERNTTMCYRSPEMIDFYSGLEIGLKSDIWALGVLLYRLCFFCVPFEESPLAIQSVNYQFPSVPNIPDEIKVLIYMLLDIDVNRRPSIYQTSVLAFEANHRKPLSEEIQNKKCTDAVPSLKSCIQLMRDGSNPRNKRDSSPRNPEAPPIQSSSKMASLSQQVPSISNISMPSGSGTVETSVAPRLRPKATTVVPNVPSISPVPPVGLPHLRLPSKGSTDETDGSQVRKVPIDFHHRQSFSGEEQLKPAAEADSAGPLSCPLIKPTDLGFTDLDKPALPRDRAQTDGKRRLPHESDIIFQQQHRRNVSDTSQISRSAFKPYSSQQTTSKTSSQVVRSVEDMSQRQNGGSGEWNPFLVAPFSNNSISRKDGQESAFMMDDSHFGMVFDEIRRKEIPAELDSETSSIDSRDPFGAAPFDQLTVSTSSSAQPVSLPPATDEDDERQLLSETDEEEKYEIDEKEEIQTKKDETINEEDSEIDEQRMNDRRRYSYENIDGVGDDASSDSRGKTDRDDSEEEEDDDSRRGGDTSHDEDSQNTVGSEDGEGGSRPLLEDDGLEDDDDHELISSFSSSSTNYPPLFIGTSTPHTQNPITNPFLRDELTPKMIITAPLPTAKNNLDDDWDLGDRWTDRRDTVFERPASEHQNVFAPATLPRQATPLVCRFKPDLPTAAPVSIIPSMSNTSFPEAVRDSDTVPCEPIIGTLISVGAPTDPPPPPLPKKPTEASPTQETTATIPVALGKKEKLLKKEKKKEKKDGKKDKLKLEEYREKGSSEPETDGSEAEIWTNDGATTFSNKKKKKSTFGLRSSHPSIVANDLQFSSPMPPVVKKSSKDKKSSLTGKNASFVNTSFQPEDHDDPTDL |
| Structure Information |
| PDB ID | NA |
| Quaternary structure | NA |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | not in DisProt |
| Predicted Disorder Regions | Predicted disorder at amino acid residues 1-7, 26-27, 342-404, 412-417, 425-477, 479, 489-572, 589-592, 615-789, 793-814, 862-865, 902-969, 979-1003, 1030-1077 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | enzyme, protein kinase involved in endocytosis |
| References for function | Filip Knop, Apolena Zounarova, Vojtech Sabata, Teije Corneel Middelkoop, Marie Macurkova (2024) Caenorhabditis elegans SEL-5/AAK1 regulates cell migration and cell outgrowth independently of its kinase activity eLife 13:e91054 |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | interacts with Wnt signalling pathway |
| References for function | Filip Knop, Apolena Zounarova, Vojtech Sabata, Teije Corneel Middelkoop, Marie Macurkova (2024) Caenorhabditis elegans SEL-5/AAK1 regulates cell migration and cell outgrowth independently of its kinase activity eLife 13:e91054 |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |