| General Information |
| MoonProt ID | 577 |
| First appeared in release | 4.0 |
| Name(s) | Phosphoglycerate mutase 2 |
| UniProt ID | P15259 |
| GO terms | GO:0007219 Notch signaling pathway
GO:0003824 catalytic activity
GO:0004082 bisphosphoglycerate mutase activity
GO:0004619 phosphoglycerate mutase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0016853 isomerase activity
GO:0016868 intramolecular phosphotransferase activity
GO:0042802 identical protein binding
GO:0006094 gluconeogenesis
GO:0006096 glycolytic process
GO:0006941 striated muscle contraction
GO:0007283 spermatogenesis
GO:0046689 response to mercury ion
GO:0061621 canonical glycolysis
GO:0005829 cytosol
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0070062 extracellular exosome |
| Organisms for which functions have been demonstrated | Homo sapiens (Human) |
| Sequence length | 253.0 |
| FASTA sequence | >sp|P15259|PGAM2_HUMAN Phosphoglycerate mutase 2 OS=Homo sapiens OX=9606 GN=PGAM2 PE=1 SV=3
MATHRLVMVRHGESTWNQENRFCGWFDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSVLKRAIRTLWAILDGTDQMWLPVVRTWRLNERHYGGLTGLNKAETAAKHGEEQVKIWRRSFDIPPPPMDEKHPYYNSISKERRYAGLKPGELPTCESLKDTIARALPFWNEEIVPQIKAGKRVLIAAHGNSLRGIVKHLEGMSDQAIMELNLPTGIPIVYELNKELKPTKPMQFLGDEETVRKAMEAVAAQGKAK |
| Structure Information |
| PDB ID | NA |
| Quaternary structure | homodimer |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | not in DisProt |
| Predicted Disorder Regions | Disorder predicted at amino acid residues 1-7, 116-120, 127-133, and 245-253 |
| Connections to Disease |
| OMIM ID | 612931 PHOSPHOGLYCERATE MUTASE 2; PGAM2 261670 GLYCOGEN STORAGE DISEASE X; GSD10 |
| Function 1 |
| Function description | enzyme, phosphoglycerate mutase, in cytoplasm, glycolysis, muscle isoform, EC 5.4.2.1, conversion of 3-phosphoglycerate (3-PG) to 2-phosphoglycerate (2-PG) |
| References for function | Wisniewski J, Barciszewski J, Turlik J, Baran K, Duda P, Jaskolski M, Rakus D. High-Resolution Crystal Structure of Muscle Phosphoglycerate Mutase Provides Insight into Its Nuclear Import and Role. Int J Mol Sci. 2022 Oct 30;23(21):13198. doi: 10.3390/ijms232113198. PMID: 36361985; PMCID: PMC9656839. |
| E.C. number | 5.4.2.11 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | binds 14-3-3 isoform zeta/delta in nucleus to stabilize the nucleolar structure |
| References for function | Wisniewski J, Barciszewski J, Turlik J, Baran K, Duda P, Jaskolski M, Rakus D. High-Resolution Crystal Structure of Muscle Phosphoglycerate Mutase Provides Insight into Its Nuclear Import and Role. Int J Mol Sci. 2022 Oct 30;23(21):13198. doi: 10.3390/ijms232113198. PMID: 36361985; PMCID: PMC9656839. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | |
| Comments | |