| General Information |
| MoonProt ID | 579 |
| First appeared in release | 4.0 |
| Name(s) | Protein ELYS |
| UniProt ID | Q5U249 |
| GO terms | GO:0003677 DNA binding
GO:0015031 protein transport
GO:0051028 mRNA transport
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005643 nuclear pore |
| Organisms for which functions have been demonstrated | Xenopus laevis (African clawed frog) |
| Sequence length | 2408.0 |
| FASTA sequence | >sp|Q5U249|ELYS_XENLA Protein ELYS OS=Xenopus laevis OX=8355 GN=ahctf1 PE=1 SV=1
MQNLEAQVTGSLVAFPDVTQKALKEDEINLDSVLRGKFSTGRTSLAWLACGPQLEITNSV
TGERISAYHFSGLTERPPVVVAVKEFTWQKKTGLLVGLVEAEGSVLCLYDIGISKVVKAV
VLPGSVTAVEPIINHGGASASTQHLHQSLRWFFGVTAVVTDVGHVLLIDLCLDEVSSNQD
ELDASDLEVMSVIPTKIPKLREAATRERRHLCLQLAAPTGTTVSCLSYISRTNQLAVGYS
DGYFSLWNMKTLRRDYHVQIEGGRVPVCAVAFQEPENDPRNCCYLWAVQSSESGGDVSLH
LLQLAFSDRKCLASGQIMYELLEYCEERYSLDLSGSTLSLRGQSNNTKLLGCQTIEKFRV
HGEREDGVHEVTSPDTSVSVFSWQVNTYGQGKPSVYLGVFDINRWYQAQMPDSLRSGQFL
RNCSYFAFWSLEAVVNITTQDIIFDILVHERSLSRGIPPSYPPPEQFYYPSTYNFDATCL
LNSGLIHFACTGFQKETLHFLKKSGSSLNEAIPDGYNRCLAAGLLAPKFTDVQASSLSQE
EQLQAILAAAVETSSLGLLTSCIKRWTAEEQPRSAANLRFVLEWTWKKVTLTKQEFDRLC
FRLFDGSCNFIDPHTLQSLQQCHLYFSNLTAVLNCFIAQAKEVTQQGAVDLTNKQSVTRL
LTLYASVVLWFCRSGMLPDSSDETVQLTRPFYNYQVIQQYYSDQRKKLERLARGKWDTSS
LMIDGLINQFGDRIQQLWSRDDNGTGKYPPANLHALLDVYLLENADEMSKHAITIYFLLD
IMYSFPDKPDSSIESFPTAFFVPGSLIKLIQGFWLLDHNDYQNSVDCILNPASSRVMSWQ
HSQIIENLLCHGDSRQALRYLQVMKPVATTSKEVKLHMTVLLANRSILEAWNLQRLHSSR
LNVEELLKHMYEMCQEMGLIEELLKLTFTDFEQGYLHKFLQTTGVQNQELLLVHHLQRAN
YISALQLNQSLKTNHLNDCDRRLRERSGARNAILDQYGKILPRVQRTLASERAKPYSLPS
LVWREVARPKPLSTTAKQAAPGSIITKANFICNVLSKIKEVSTANEKREEYSPYQSMVSE
EPTAPPLQDIDVPDAFFGTPINKSRRVSRLLDSVVHPVLMEPTPLTSSDTDNNQTPHKSP
LLKTSSPLHSSLRRIAHMRSFAKASEFSLLETPLVVRKAKALAANTASSGYTSITPQSIL
RSSVRTTPLVSPSVSPGRSLTPPLRPKETKISFMELSFTRHAKAAHSSEGNLLAISPVLR
SSPDAVWSVKGKVASFTQNTPVKKLDEIDASSSGIQEESQDEMEVSKEISNISVRSEQAS
LEYHDAPTPEDLENDEISGTTNSQPQVNEVHHQMEDGQLTEKPAELALTEMQEEFIDSEE
REIEYISAPLNGPNALECMTAVPDIYLEDASQCILETPEGSSVSVTGEQECVSSAKDSES
VISIHDSDDAHSNLSENDQDSEEIEENNLRVPTTVTRCEEFDLIETKDLEVELEEADSEK
TNYKDIYPDATVQLGFTVESIEQRYTCELADRRETPSETDEIEGEHFETENNFSLVLEGD
VTEEEILEPSSSKTDLELTRPPIAHQKLISENRENIENCETTEKIPANMSPLVDSDHESK
TLETLPSEADLSVAEKVLKGTEEKDVPPEVHSEVVLESKLVGNAMMSLDSSESQEVIISQ
YDNVISIEKLEMTQEKMYGEKTEQINEGQVSPNRDQSTLVKPLTPRRSIRKSSKPADSST
DIIGNITLPTTPKRGLKKAKENVDTLKNSISVVPEEELTLGTRRITRKATLTALDNPEPL
QIKEPPSGEDLQVQPSTPTRGRRGKVITSDDLKEPPSGEDLQVQPSTPTRGRRGRVITSD
DLREPPPGEDLQVQPSTPTRGRRGRVITSDDIKESPSVEDLQVQPSTPTRGRRGKVITSD
DIKEPPSVEDLQVQPSTPTRGRKGKVITSDDIKEPLSGEDLQVQPSTPTRGRKGKVITSD
DIKEPLSEEVLQEQPSTPTRGRRGRVITSDGKGYECVEEKNALPLTPTRITRSKNILEPE
KGISQIEPEKGISQIEPDKGLSQIEDTGETEHEVVTPRRGRRGKRVVNELVKHFERNSSQ
PNIKADTSPPVSPKKVSLRWTRTRSENQRINATEEQASKIQEDLSDTPRKRYKKSSNKMG
FEETTDTVTEGAIVEDVQESLIISHLGKNPNTSIVRSARKTALPPVTEDHSEQPLLPPES
HSKVHSSLAIADEENKTNTRTRSGNKSSVDVSAITFEFSTPKARTKKTAKGSAVPTELIP
STQYVFSPPSTRTRRATRANVSEAVIEPQLQFQESCEIAETEVPEVPASKPRGRPPKHKA
KAVTRVLKKPSWSTPPVEIKLISPPESPAVSETNTKTDSTEAKGAEKISVRRTRRRIIAK
PVTRRKMR |
| Structure Information |
| PDB ID | 7VCI 7WB4 |
| Quaternary structure | NA |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | DP00005 |
| Predicted Disorder Regions | Predicted disorder at N terminus (aa 1-6), middle region multiple areas, and C terminus (aa 2389-2408) |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | binds chromatin and seeds nuclear pore complex assembly |
| References for function | Yokoyama H, Koch B, Walczak R, Ciray-Duygu F, Gonzalez-Sanchez JC, Devos DP, Mattaj IW, Gruss OJ. The nucleoporin MEL-28 promotes RanGTP-dependent gamma-tubulin recruitment and microtubule nucleation in mitotic spindle formation. Nat Commun. 2014;5:3270. doi: 10.1038/ncomms4270. PMID: 24509916. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | nucleus |
| Comments | |
| Function 2 |
| Function description | binds microtubules, interacts with gamma-tubulin ring complex and recruits it to microtubule nucleation sites. |
| References for function | Yokoyama H, Koch B, Walczak R, Ciray-Duygu F, Gonzalez-Sanchez JC, Devos DP, Mattaj IW, Gruss OJ. The nucleoporin MEL-28 promotes RanGTP-dependent gamma-tubulin recruitment and microtubule nucleation in mitotic spindle formation. Nat Commun. 2014;5:3270. doi: 10.1038/ncomms4270. PMID: 24509916. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | mitotic spindle |
| Comments | |