| General Information |
| MoonProt ID | 585 |
| First appeared in release | 4.0 |
| Name(s) | Elongation factor 2 |
| UniProt ID | G8BE22 |
| GO terms | "GO:0000166 nucleotide binding
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0043022 ribosome binding
GO:0006412 translation
GO:0006414 translational elongation
GO:0005575 cellular_component cellular_component
GO:0005737 cytoplasm
GO:1990904 ribonucleoprotein complex |
| Organisms for which functions have been demonstrated | Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia parapsilosis) |
| Sequence length | 842 |
| FASTA sequence | >tr|G8BE22|G8BE22_CANPC Elongation factor 2 OS=Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) OX=578454 GN=CPAR2_211630 PE=4 SV=1 MVAFTIEQIRDLMDKVTNVRNMSVIAHVDHGKSTLTDSLVQKAGIISAGKAGEARFMDTR KDEQERGITIKSTAISLYAGMTDEDVKDIKQKTEGNSFLINLIDSPGHVDFSSEVTAALR VTDGALVVVDTVEGVCVQTETVLRQALGERIKPVVIINKVDRALLELQVTKEDLYQSFAR TVESVNVIISTYVDPVLGDAQVFPDKGTVAFGSGLHGWAFTVRQFATKYSKKFGVDRSKM MERLWGDSYFNPKTKKWTNKDKDADGKPLERAFNMFVLDPIFRLFGAIMNFKKEEIPVLL EKLEINLKSDEKELEGKALLKVVMRKFLPAADALLEMIVLHLPSPVTAQNYRAETLYEGP SDDAICNGIRNCDPKADLMLYVSKMVPTSDKGRFYAFGRVFSGTVKSGQKVRIQGPNYQV GKKDDLFIKSIQRTVLMMGRNVEQIDDCPAGNIVGLVGIDQFLLKSGTITTSESAHNLKV MKFSVSPVVQVAVEVKNANDLPKLVEGLKRLSKSDPCVLTSMNESGEHIVAATGELHLEI CLSDLENDHAGVPIRVSPPVVSYRETVESESSMVALSKSPNKHNRIYVKAQPIDEEVSLD IENGVINPRDDFKARARILADKHGWDVTDARKIWCFGPDGNGPNLVVDQTKAVQYLNEIK DSVVAAFQWATKEGPIFGENCRSVRINILDVTLHADAIHRGGGQIIPTMRRVTYASMLLA EPAIQEPIFLVEIQCPENAIGGIYSVLNKKRGQVISEEQRPGTPLFTVKAYLPVNESFGF TGELRQATGGQAFPQLIFDHWSILNGDVKDPSSKPGLIVKEKRERQGLKPEVPDYTEYYD KL |
| Structure Information |
| PDB ID | NA |
| Quaternary structure | NA |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | not in DisProt |
| Predicted Disorder Regions | Predicted disorder at N terminus (aa 1-3), middle region (aa 56-61, 260-261, 815-822), and C terminus (aa 833-842) |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | elongation factor in protein biosynthesis |
| References for function | Kozik A, Karkowska-Kuleta J, Zajac D, Bochenska O, Kedracka-Krok S, Jankowska U, Rapala-Kozik M. Fibronectin-, vitronectin- and laminin-binding proteins at the cell walls of Candida parapsilosis and Candida tropicalis pathogenic yeasts. BMC Microbiol. 2015 Oct 5;15:197. doi: 10.1186/s12866-015-0531-4. PMID: 26438063; PMCID: PMC4595241. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | binds fibronectin |
| References for function | Kozik A, Karkowska-Kuleta J, Zajac D, Bochenska O, Kedracka-Krok S, Jankowska U, Rapala-Kozik M. Fibronectin-, vitronectin- and laminin-binding proteins at the cell walls of Candida parapsilosis and Candida tropicalis pathogenic yeasts. BMC Microbiol. 2015 Oct 5;15:197. doi: 10.1186/s12866-015-0531-4. PMID: 26438063; PMCID: PMC4595241. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | |
| Comments | |