| General Information |
| MoonProt ID | 61 |
| First appeared in release | 1.0 |
| Name(s) | GAPDH
glyceraldehyde 3-phosphate dehydrogenase
gap
Gene Name: gapA
|
| UniProt ID | P47543 (G3P_MYCGE), Reviewed |
| GO terms | GO:0006006 glucose metabolic process
GO:0006096 glycolysis
GO:0055114 oxidation-reduction process
GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0050661 NADP binding
GO:0051287 NAD binding
GO:0005737 cytoplasm |
| Organisms for which functions have been demonstrated | Mycoplasma genitalium |
| Sequence length | 337 |
| FASTA sequence | >sp|P47543|G3P_MYCGE Glyceraldehyde-3-phosphate dehydrogenase OS=Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) GN=gapA PE=3 SV=1
MAAKNRTIKVAINGFGRIGRLVFRSLLSKANVEVVAINDLTQPEVLAHLLKYDSAHGELKRKITVKQNILQIDRKKVYVFSEKDPQNLPWDEHDIDVVIESTGRFVSEEGASLHLKAGAKRVIISAPAKEKTIRTVVYNVNHKTISSDDKIISAASCTTNCLAPLVHVLEKNFGIVYGTMLTVHAYTADQRLQDAPHNDLRRARAAAVNIVPTTTGAAKAIGLVVPEANGKLNGMSLRVPVLTGSIVELSVVLEKSPSVEQVNQAMKRFASASFKYCEDPIVSSDVVSSEYGSIFDSKLTNIVEVDGMKLYKVYAWYDNESSYVHQLVRVVSYCAKL
|
| Structure Information |
| PDB ID | 7JWK |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-5, 337 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | glyceraldehyde 3-phosphate dehydrogenase, enzyme
D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 1,3-bisphosphoglycerate + NADH
Carbohydrate degradation, glycolysis |
| References for function | demonstrated enzyme activity: Alvarez RA, Blaylock MW, Baseman JB: Surface localized glyceraldehyde-3-phosphate dehydrogenase of Mycoplasma genitalium binds mucin. Mol Microbiol 2003, 48(5):1417-1425. |
| E.C. number | 1.2.1.12 |
| Location of functional site(s) | |
| Cellular location of function | |
| Comments | |
| Function 2 |
| Function description | binds mucin |
| References for function | Alvarez RA, Blaylock MW, Baseman JB: Surface localized glyceraldehyde-3-phosphate dehydrogenase of Mycoplasma genitalium binds mucin. Mol Microbiol. 2003 Jun;48(5):1417-25.
PMID: 12787366 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |