| General Information |
| MoonProt ID | 688 |
| First appeared in release | 4.0 |
| Name(s) | DOMINO-A |
| UniProt ID | Q9NDJ2 |
| GO terms | >sp|Q9NDJ2|DOM_DROME Helicase domino OS=Drosophila melanogaster OX=7227 GN=dom PE=1 SV=2
MNEGNSAGGGHEGLSPAPPAVPDRVTPHSTEISVAPANSTSTTVRAAGSVGAALPATRHH
QHIATQVKGIASSSSKQQKQLASAQLPVPLSPLPQQQQQTAEATAAAAAPAHSNVSVSSS
TIEASVLPPQAKRQRLDDNEDRTSAASIVGPAESSNIVSSLLPASVASSSEVGGLSSTAL
QDLNALKKRILQQKLQILRNLKERHLENVSEYFYLQNGGSMMDYPAWRKKTPTPQFISYS
NANRIDQLIHEDKPSTSAAAAAAQNQKYTTQQTDSVESSLVSGIGTGATKGAPLDGNISN
STVKTNTQSQVPSKIGSFTESTPAATESNSSTTVPGTATSGAATSTSATSAEASGNVLAV
EAEIKIPAVGATPVAISTKLPAAVVQLTQQGGTPLLPCNTSAGSTALRRPQGQNNASSGS
AAASGGGGSLTPTPLYTGNGPAALGGSGGLTPGTPTSGSLLSPALGGGSGTPNSAAQEFS
FKAKQEVYVMQRISELQREGLWTERRLPKLQEPSRPKAHWDYLLEEMVWLAADFAQERKW
KKNAAKKCAKMVQKYFQDKATAAQRAEKAQELQLKRVASFIAREVKSFWSNVEKLVEYKH
QTKIEEKRKQALDQHLSFIVDQTEKFSQQLVEGMNKSVADTPSLNSSRLTSPKRESDDDF
RPESGSEDDEETIAKAEEDAADVKEEVTALAKESEMDFDDFLNDLPPGYLENRDKLMKEE
QSSAIKTETPDDSDDSEFEAKEASDDDENTISKQEEAEQEIDHKKEIDELEADNDLSVEQ
LLAKYKSEQPPSPKRRKLAPRDPELDSDDDSTAVDSTEESEDAATEDEEDLSTVKTDTDM
EEQDEQEDGLKSLMADADATSGAAGSGSTAGASGNKDDMLNDAAALAESLQPKGNTLSST
NVVTPVPFLLKHSLREYQHIGLDWLVTMNERKLNGILADEMGLGKTIQTIALLAHLACAK
GNWGPHLIVVPSSVMLNWEMEFKKWCPGFKILTYYGSQKERKLKRVGWTKPNAFHVCITS
YKLVVQDQQSFRRKKWKYLILDEAQNIKNFKSQRWQLLLNFSTERRLLLTGTPLQNDLME
LWSLMHFLMPYVFSSHREFKEWFSNPMTGMIEGNMEYNETLITRLHKVIRPFLLRRLKKE
VEKQMPKKYEHVITCRLSNRQRYLYEDFMSRAKTRETLQTGNLLSVINVLMQLRKVCNHP
NMFEARPTISPFQMDGITFHTPRLVCDIMEYDPFTQINLETLNLLLLHLEQTMTAYVSHK
SRLLAPPRKLIEDIDTAPLPAPRCPNGKYRFHIRVRSAELAQRIKLNAVKVGASPAMRLE
GSKIMPMRNLLPSGRVLKRVSASINPVNMALKPVVINSVVTTTSSSTTASSPTGALSVLS
NSKLLGARSQINAPTPAKVAKTMQDGKPFFYLTPATNSGAAGARLTLTSKTTASASTTTS
RTTVTASTTSGQQLIRDPIVKDLATHVKSTVQKQSIANGKTEPEEETEAEDPYKVQELIQ
MRKEQRLAALKRMAMINRRRTDATPIYGEDCREAIQRCMQATRSLKRSTWQTRGYANCCT
AMAHRNGWSLNHLLKSFEERCADLKPVFANFVIYVPSVCAPRIRRYVQNLSSTHWQHEQR
IENIVDQALRPKLALLHPIISEMTTKFPDPRLIQYDCGKLQTMDRLLRQLKVNGHRVLIF
TQMTKMLDVLEAFLNYHGHIYLRLDGSTRVEQRQILMERFNGDKRIFCFILSTRSGGVGI
NLTGADTVIFYDSDWNPTMDAQAQDRCHRIGQTRDVHIYRLVSERTIEVNILKKANQKRM
LSDMAIEGGNFTTTYFKSSTIKDLFTMEQSEQDESSQEKSENKDRIVATTTLSDTPSTVV
ETEKQSLRAFEHALAAAEDEQDVQATKTAKAEVAADLAEFDENIPIATEDPNAEGGPQVE
LSKADLEMQNLVKQLSPIERYAMRFVEETGAAWTAEQLRAAEAELEAQKREWEANRLAAM
HKEEELLKQETEAEEMLTYSRKDSSNQVWISRNTMEQMPMWCPPTPPQDNDNDIYIDYSL
SFMYELEPIAETDLPPVYVRKEHKRSRTDAGYDGSRRPNKMRREDNYVPPRSLFDRPTPQ
LARLRRELKSQRFRGSFKPNMPIPGLKPQLPTKPLTEPEAMAEWCVFEDMAILHVLVNLQ
GLPCSLMLLSPGQTPNWDLVSEMVNFCSKTYRSARQCRWRYETHIQPREEGKVVESPKKQ
KKLKPTLRTEYLKSPLRYLRTTQLYVSDNNASFYKTMRSRFDSIKTAYLKKAPPPKRQFS
APSLMNPKHMEVLQEFGILNYDQPVSPQNIAAMKANKIREKQRGQQMSQPPVGVGVVQQM
QQQSQQQQQPAPPPLPQQQQPQQVVQQVQQQQQQQQQQQQQQVVQQQLPTVSNVQQTLPV
QQTVELVQQQPTTTTTVAVPAAGGQLQQLQIQHLTSSNVSPGQQTAILLHQPQQQLRTHP
GQGGQSNTQQLVKTIVGTSSSLTAGQLQQLAQQSAVASGGQSSVSVVLTTPVQTLPSVVQ
PQIGSGAQIVSISSQTLPVNSSPQLGSIVQTQSLPQVVSVSTLPTVGTVLTTTANQPQQQ
HQTTAVTTLNTTMLRGQRIVSTAAGNTLQQRTTAGGQSIVSMPNLGQGASPSQFQTQLRL
AAVPTSPATQTTQLVTTKGIPVSALQQGGKTTVIPVTQQSGGAHIQLYRQRSLKVLQTTT
QAVPSGSAGATGATANLVQAGGTIIQASNMATHVTSQKVAVSGMPGTSTTVQAGNVVSSV
QMHGQARTQFIKQMAAGKQQLQRQVVSADGTTTTTAAGDMLLVKRHNILAAQKAQQASGA
LFTTTTGQQQQQQQQQGQLPVAGQPQQVTQHQIASLVKASTAAAASGSSVNAGGVTVSAT
NPTVQAGSVNMTLPQLKPGSQIKVTMPNQMRHLQMQQQLTMPRKISRMTQLVSASGQPTA
TNIITTTGPQQQQQGVTVSGGGTLPTVASQQQQQQHQQKVGGGNSVQAQLLHIQNTKGLS
NSVTMQQIQQVMRSGQQGTLATTNLVLGKTSVGRVIPVSVASQANQRQTIQVVSAASAQA
LAAGNLRTHVAGPSIASTLKVAAPGSAGGQTTQQTLIAALQHNQRQNASPVRLQTTAGGN
LLAVVQQQQQQQHTSIAGPTAGPAEVMTITQTTTTLPTVGSLQQQQQQQQQQGGISQPTT
QQVRKLVQKKILIRSEKE |
| Organisms for which functions have been demonstrated | Drosophila melanogaster (fruit fly) |
| Sequence length | 1386.0 |
| FASTA sequence | >UPI000052B845 status=inactive MSGSGATGSGSAAGLSSSTNTNCKTSTSARSSGNSTNNNSISTGKKPKSTTAAAATTPEACGSENGYHSRSSTSPTPTSDEVSVASLTAATAGSRPSKSPLTPTETIGATSGESAMTLHSPAGTPARARKPPEAFATSLLNLEVKVLTQALGAENQWAEQGDGRVVFSDFTIRVIAAGVGKDETQRERKTAELTSSGAADAATASGNDGVGAAPRKSVATSDASALSNTVSEFEEDDTAD ELIILEDTISNDTPFVGENCCIVWNSFEKQLSLCLMYASEEGYSASWSALVALQDKSYPPFRFDLLERCRPVSERTALAPGDSTSSLTPSTAATDKTEDVVLPYSYFIHTKYDPPLGFIEHHALSLSIIEHRHATNPALYADKETVLKMLNMANADLLDYLISEDTFPLLLSGLQCTAAPRSWSVPEPLRLLHIPEEVITFIRKDRWIGFLQNTVLPSCGAADSVAELIAKYATMSRRVRNDIVCALLTCDSMFSEACEALRVLPQVTPAMASGGSSARNRGLSVEASLSVTSLSSEGRC SMSGVGNGAPSPSSTPPAVDTVPPAQKAELQVLAHLRFFRELVTLSIAELGREMVGPIVGKIYQSGVLEPLSLVAERFAMPNGTAAAFVKHIMDGSGGALNGARRNGGGGSASNSNSAAAGGTSSTANCYSLAVEQELAAVLDVTLVRLNERQEEQLMNEHVRSPILADPVKYNGIVTFMLRQLIVGGPIGAAFATSGTGTNATRSSLSIFPPPKRILRDSMSSTNPFALFHVLGLHDDEGSAASERKLDSESTGIRNRFHNFIITKYIAHATRGVMTPVPLPPSLGGVVGSTRNIPIVQFNNANASQNGGARPVHQDGNGSDTASATVGAPNTCPAAGGGGSGAASPVLPLPQGITPALIRVLEYMVNLTNNANRELILKTVFHYKSHIWHFIEGVCDTLCGENGAGARCQIGLDVLCGCVRFLKVVVTQMTVITAEVDENPLSSYASSREPLSPQLVTTICRQLTVERDTFGYFLKAYNELGGRRRDSVFHSSLLSVLDIIGKCSVHEPEDSTTNNLRDVRDYLFFKHFTRLPEVFAC RYREALLSEVTVRLGQEATHSPNDSVSVLSSTAGSELTRCSSKLRFVDEVDAVSGGVDGTVVPSSVVSPAIMVSMANAEEKQRRRHGRSSMEQWNATANIAMGSPLQVRSVASLGLADDHGTRASPSSSPPSRKSSPLTISITRPGSGSNSSSGSAGSSRTPAGDLLKVNAAQHNGSSVNGDGPLAQASPPSTVVPTTRKADTVLRPTAPKEEKPPARPRNFASVLENPSRTNAAASGEQ GRKSRSMPNATAKHAPPSPEKVLLSRTGQSSVPQSVEHANGTALPFSDNVVLPKIKKLLSTGGKRS |
| Structure Information |
| PDB ID | NA |
| Quaternary structure | NA |
| SCOP | |
| CATH | |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | |
| Predicted Disorder Regions | Predicted disorder at N terminus (aa 1-41), middle regions (aa 46-110, 119-148, 249-254, 256-266, 270-273, 282-283, 294-345, 397-475, 632-690, 699-705, 709-875, 885-886, 1396-1397, 1440-1449, 1472-1496, 1826-1863, 1883-1886, 1901-1922, 1996-1998, 2019-2026, 2059-2132, 2211-2221, 2276-2284, 2311-2362, 2442-2471, 2583-2588, 2602-2609, 2614-2630, 2636-2641, 2833-2843, 2889-2893, 2897-2902, 2907-2913, 2921-2927, 2932-2984, 3095-3101, 3133-3151, 3161-3177), and C terminus (aa 3190-3198) |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | component of DOM/TIP60 chromatin remodeling complex |
| References for function | _ |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | nucleus |
| Comments | |
| Function 2 |
| Function description | localize along the microtubular structure of the spindle in the meiotic apparatus during meiosis |
| References for function | Prozzillo, Y., Fattorini, G., Ferreri, D., Leo, M., Dimitri, P., & Messina, G. (2023). Knockdown of DOM/Tip60 Complex Subunits Impairs Male Meiosis of Drosophila melanogaster. Cells, 12(10), 1348. https://doi.org/10.3390/cells12101348 |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | localize along the microtubular structure of the spindle in the meiotic apparatus during meiosis |
| Comments | |