| General Information |
| MoonProt ID | 688 |
| First appeared in release | 4.0 |
| Name(s) | DOMINO-A |
| UniProt ID | Q9NDJ2 |
| GO terms | >sp|Q9NDJ2|DOM_DROME Helicase domino OS=Drosophila melanogaster OX=7227 GN=dom PE=1 SV=2
MNEGNSAGGGHEGLSPAPPAVPDRVTPHSTEISVAPANSTSTTVRAAGSVGAALPATRHH
QHIATQVKGIASSSSKQQKQLASAQLPVPLSPLPQQQQQTAEATAAAAAPAHSNVSVSSS
TIEASVLPPQAKRQRLDDNEDRTSAASIVGPAESSNIVSSLLPASVASSSEVGGLSSTAL
QDLNALKKRILQQKLQILRNLKERHLENVSEYFYLQNGGSMMDYPAWRKKTPTPQFISYS
NANRIDQLIHEDKPSTSAAAAAAQNQKYTTQQTDSVESSLVSGIGTGATKGAPLDGNISN
STVKTNTQSQVPSKIGSFTESTPAATESNSSTTVPGTATSGAATSTSATSAEASGNVLAV
EAEIKIPAVGATPVAISTKLPAAVVQLTQQGGTPLLPCNTSAGSTALRRPQGQNNASSGS
AAASGGGGSLTPTPLYTGNGPAALGGSGGLTPGTPTSGSLLSPALGGGSGTPNSAAQEFS
FKAKQEVYVMQRISELQREGLWTERRLPKLQEPSRPKAHWDYLLEEMVWLAADFAQERKW
KKNAAKKCAKMVQKYFQDKATAAQRAEKAQELQLKRVASFIAREVKSFWSNVEKLVEYKH
QTKIEEKRKQALDQHLSFIVDQTEKFSQQLVEGMNKSVADTPSLNSSRLTSPKRESDDDF
RPESGSEDDEETIAKAEEDAADVKEEVTALAKESEMDFDDFLNDLPPGYLENRDKLMKEE
QSSAIKTETPDDSDDSEFEAKEASDDDENTISKQEEAEQEIDHKKEIDELEADNDLSVEQ
LLAKYKSEQPPSPKRRKLAPRDPELDSDDDSTAVDSTEESEDAATEDEEDLSTVKTDTDM
EEQDEQEDGLKSLMADADATSGAAGSGSTAGASGNKDDMLNDAAALAESLQPKGNTLSST
NVVTPVPFLLKHSLREYQHIGLDWLVTMNERKLNGILADEMGLGKTIQTIALLAHLACAK
GNWGPHLIVVPSSVMLNWEMEFKKWCPGFKILTYYGSQKERKLKRVGWTKPNAFHVCITS
YKLVVQDQQSFRRKKWKYLILDEAQNIKNFKSQRWQLLLNFSTERRLLLTGTPLQNDLME
LWSLMHFLMPYVFSSHREFKEWFSNPMTGMIEGNMEYNETLITRLHKVIRPFLLRRLKKE
VEKQMPKKYEHVITCRLSNRQRYLYEDFMSRAKTRETLQTGNLLSVINVLMQLRKVCNHP
NMFEARPTISPFQMDGITFHTPRLVCDIMEYDPFTQINLETLNLLLLHLEQTMTAYVSHK
SRLLAPPRKLIEDIDTAPLPAPRCPNGKYRFHIRVRSAELAQRIKLNAVKVGASPAMRLE
GSKIMPMRNLLPSGRVLKRVSASINPVNMALKPVVINSVVTTTSSSTTASSPTGALSVLS
NSKLLGARSQINAPTPAKVAKTMQDGKPFFYLTPATNSGAAGARLTLTSKTTASASTTTS
RTTVTASTTSGQQLIRDPIVKDLATHVKSTVQKQSIANGKTEPEEETEAEDPYKVQELIQ
MRKEQRLAALKRMAMINRRRTDATPIYGEDCREAIQRCMQATRSLKRSTWQTRGYANCCT
AMAHRNGWSLNHLLKSFEERCADLKPVFANFVIYVPSVCAPRIRRYVQNLSSTHWQHEQR
IENIVDQALRPKLALLHPIISEMTTKFPDPRLIQYDCGKLQTMDRLLRQLKVNGHRVLIF
TQMTKMLDVLEAFLNYHGHIYLRLDGSTRVEQRQILMERFNGDKRIFCFILSTRSGGVGI
NLTGADTVIFYDSDWNPTMDAQAQDRCHRIGQTRDVHIYRLVSERTIEVNILKKANQKRM
LSDMAIEGGNFTTTYFKSSTIKDLFTMEQSEQDESSQEKSENKDRIVATTTLSDTPSTVV
ETEKQSLRAFEHALAAAEDEQDVQATKTAKAEVAADLAEFDENIPIATEDPNAEGGPQVE
LSKADLEMQNLVKQLSPIERYAMRFVEETGAAWTAEQLRAAEAELEAQKREWEANRLAAM
HKEEELLKQETEAEEMLTYSRKDSSNQVWISRNTMEQMPMWCPPTPPQDNDNDIYIDYSL
SFMYELEPIAETDLPPVYVRKEHKRSRTDAGYDGSRRPNKMRREDNYVPPRSLFDRPTPQ
LARLRRELKSQRFRGSFKPNMPIPGLKPQLPTKPLTEPEAMAEWCVFEDMAILHVLVNLQ
GLPCSLMLLSPGQTPNWDLVSEMVNFCSKTYRSARQCRWRYETHIQPREEGKVVESPKKQ
KKLKPTLRTEYLKSPLRYLRTTQLYVSDNNASFYKTMRSRFDSIKTAYLKKAPPPKRQFS
APSLMNPKHMEVLQEFGILNYDQPVSPQNIAAMKANKIREKQRGQQMSQPPVGVGVVQQM
QQQSQQQQQPAPPPLPQQQQPQQVVQQVQQQQQQQQQQQQQQVVQQQLPTVSNVQQTLPV
QQTVELVQQQPTTTTTVAVPAAGGQLQQLQIQHLTSSNVSPGQQTAILLHQPQQQLRTHP
GQGGQSNTQQLVKTIVGTSSSLTAGQLQQLAQQSAVASGGQSSVSVVLTTPVQTLPSVVQ
PQIGSGAQIVSISSQTLPVNSSPQLGSIVQTQSLPQVVSVSTLPTVGTVLTTTANQPQQQ
HQTTAVTTLNTTMLRGQRIVSTAAGNTLQQRTTAGGQSIVSMPNLGQGASPSQFQTQLRL
AAVPTSPATQTTQLVTTKGIPVSALQQGGKTTVIPVTQQSGGAHIQLYRQRSLKVLQTTT
QAVPSGSAGATGATANLVQAGGTIIQASNMATHVTSQKVAVSGMPGTSTTVQAGNVVSSV
QMHGQARTQFIKQMAAGKQQLQRQVVSADGTTTTTAAGDMLLVKRHNILAAQKAQQASGA
LFTTTTGQQQQQQQQQGQLPVAGQPQQVTQHQIASLVKASTAAAASGSSVNAGGVTVSAT
NPTVQAGSVNMTLPQLKPGSQIKVTMPNQMRHLQMQQQLTMPRKISRMTQLVSASGQPTA
TNIITTTGPQQQQQGVTVSGGGTLPTVASQQQQQQHQQKVGGGNSVQAQLLHIQNTKGLS
NSVTMQQIQQVMRSGQQGTLATTNLVLGKTSVGRVIPVSVASQANQRQTIQVVSAASAQA
LAAGNLRTHVAGPSIASTLKVAAPGSAGGQTTQQTLIAALQHNQRQNASPVRLQTTAGGN
LLAVVQQQQQQQHTSIAGPTAGPAEVMTITQTTTTLPTVGSLQQQQQQQQQQGGISQPTT
QQVRKLVQKKILIRSEKE |
| Organisms for which functions have been demonstrated | Drosophila melanogaster (fruit fly) |
| Sequence length | 1386.0 |
| FASTA sequence | >UPI000052B845 status=inactive MSGSGATGSGSAAGLSSSTNTNCKTSTSARSSGNSTNNNSISTGKKPKSTTAAAATTPEACGSENGYHSRSSTSPTPTSDEVSVASLTAATAGSRPSKSPLTPTETIGATSGESAMTLHSPAGTPARARKPPEAFATSLLNLEVKVLTQALGAENQWAEQGDGRVVFSDFTIRVIAAGVGKDETQRERKTAELTSSGAADAATASGNDGVGAAPRKSVATSDASALSNTVSEFEEDDTAD ELIILEDTISNDTPFVGENCCIVWNSFEKQLSLCLMYASEEGYSASWSALVALQDKSYPPFRFDLLERCRPVSERTALAPGDSTSSLTPSTAATDKTEDVVLPYSYFIHTKYDPPLGFIEHHALSLSIIEHRHATNPALYADKETVLKMLNMANADLLDYLISEDTFPLLLSGLQCTAAPRSWSVPEPLRLLHIPEEVITFIRKDRWIGFLQNTVLPSCGAADSVAELIAKYATMSRRVRNDIVCALLTCDSMFSEACEALRVLPQVTPAMASGGSSARNRGLSVEASLSVTSLSSEGRC SMSGVGNGAPSPSSTPPAVDTVPPAQKAELQVLAHLRFFRELVTLSIAELGREMVGPIVGKIYQSGVLEPLSLVAERFAMPNGTAAAFVKHIMDGSGGALNGARRNGGGGSASNSNSAAAGGTSSTANCYSLAVEQELAAVLDVTLVRLNERQEEQLMNEHVRSPILADPVKYNGIVTFMLRQLIVGGPIGAAFATSGTGTNATRSSLSIFPPPKRILRDSMSSTNPFALFHVLGLHDDEGSAASERKLDSESTGIRNRFHNFIITKYIAHATRGVMTPVPLPPSLGGVVGSTRNIPIVQFNNANASQNGGARPVHQDGNGSDTASATVGAPNTCPAAGGGGSGAASPVLPLPQGITPALIRVLEYMVNLTNNANRELILKTVFHYKSHIWHFIEGVCDTLCGENGAGARCQIGLDVLCGCVRFLKVVVTQMTVITAEVDENPLSSYASSREPLSPQLVTTICRQLTVERDTFGYFLKAYNELGGRRRDSVFHSSLLSVLDIIGKCSVHEPEDSTTNNLRDVRDYLFFKHFTRLPEVFAC RYREALLSEVTVRLGQEATHSPNDSVSVLSSTAGSELTRCSSKLRFVDEVDAVSGGVDGTVVPSSVVSPAIMVSMANAEEKQRRRHGRSSMEQWNATANIAMGSPLQVRSVASLGLADDHGTRASPSSSPPSRKSSPLTISITRPGSGSNSSSGSAGSSRTPAGDLLKVNAAQHNGSSVNGDGPLAQASPPSTVVPTTRKADTVLRPTAPKEEKPPARPRNFASVLENPSRTNAAASGEQ GRKSRSMPNATAKHAPPSPEKVLLSRTGQSSVPQSVEHANGTALPFSDNVVLPKIKKLLSTGGKRS |
| Structure Information |
| PDB ID | NA |
| Quaternary structure | NA |
| SCOP | |
| CATH | |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | |
| Predicted Disorder Regions | |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | component of DOM/TIP60 chromatin remodeling complex |
| References for function | _ |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | nucleus |
| Comments | |
| Function 2 |
| Function description | localize along the microtubular structure of the spindle in the meiotic apparatus during meiosis |
| References for function | Prozzillo, Y., Fattorini, G., Ferreri, D., Leo, M., Dimitri, P., & Messina, G. (2023). Knockdown of DOM/Tip60 Complex Subunits Impairs Male Meiosis of Drosophila melanogaster. Cells, 12(10), 1348. https://doi.org/10.3390/cells12101348 |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | localize along the microtubular structure of the spindle in the meiotic apparatus during meiosis |
| Comments | |