| General Information |
| MoonProt ID | 69 |
| First appeared in release | 1.0 |
| Name(s) | Hsp60
Heat shock protein 60, mitochondrial
Antigen HIS-62
Gene Name: HSP60 |
| UniProt ID | P50142 (HSP60_AJECA), Reviewed |
| GO terms | GO:0006457 protein folding
GO:0006950 response to stress
GO:0042026 protein refolding
GO:0044267 cellular protein metabolic process
GO:0000166 nucleotide binding
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005739 mitochondrion |
| Organisms for which functions have been demonstrated | Histoplasma capsulatum (Hc strain G217B) - also known as Ajellomyces capsulatus, causes hostoplsmosis, Darling's disease) |
| Sequence length | 590 |
| FASTA sequence | >gi|4558517|gb|AAB46362.2| heat shock protein 60 [Ajellomyces capsulatus]
MQRALSSTSRASVLSSAPTRAPVSRFRSAGLSLQQQRFAHKELKFGVEGRAALLKGIDTLAKAVCTTLGPKGRNVLIESSYGSPKITKDGVTVAKAVTLQDKFENLGARLLQDVASKTNEVAGDGTTTATVLARAIFSETVKNVAAGCNPMDLRRGIQAAVEAVVEYLQANKRDITTTEEIAQVATISANGDTHVGKLISNAMEKVGKEGVITVKDGKTIEDELEVTEGMRFDRGYVSPYFITDTKAQKVEFEKPLIVLSEKKISAVQDIIPALEASTTLRRPLVIIAEDIEGEALAVCILNKLRGQLQVAAVKVPGFGDNRKSILGDIGILTNATVFTDELDMKLEKATADMLGSTGSITITKEDTIILNGDGSKDSIAQRCEQIRGVIADPTTSDYEKEKLQERLAKLSGGVAVIKVGGASEVEVGEKKDRVVDALNATRAAVEEGILPGGGTALLKAAANGLASVKPTSSDQLRRISSLVSAITRPARTIVENAGLEGSVIVGKLTDEHASDFNRGFDSAKGEYVDMIASGIVDPLKVVRTALVDASGVASLLGTTEVAIVEAPEEKGPAGPPGGMGGMGGMGGGMF |
| Structure Information |
| PDB ID | closest is human at 57% amino acid sequence identity |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-33, 390-397, 569-590 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | Hsp60 |
| References for function | |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | mitochondrion |
| Comments | |
| Function 2 |
| Function description | adhesin |
| References for function | Long KH, Gomez FJ, Morris RE, Newman SL.Identification of heat shock protein 60 as the ligand on Histoplasma capsulatum that mediates binding to CD18 receptors on human macrophages. J Immunol. 2003 Jan 1;170(1):487-94.
PMID: 12496435 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |