General Information |
MoonProt ID | 69 |
First appeared in release | 1.0 |
Name(s) | Hsp60
Heat shock protein 60, mitochondrial
Antigen HIS-62
Gene Name: HSP60 |
UniProt ID | P50142 (HSP60_AJECA), Reviewed |
GO terms | GO:0006457 protein folding
GO:0006950 response to stress
GO:0042026 protein refolding
GO:0044267 cellular protein metabolic process
GO:0000166 nucleotide binding
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005739 mitochondrion |
Organisms for which functions have been demonstrated | Histoplasma capsulatum (Hc strain G217B) - also known as Ajellomyces capsulatus, causes hostoplsmosis, Darling's disease) |
Sequence length | 590 |
FASTA sequence | >gi|4558517|gb|AAB46362.2| heat shock protein 60 [Ajellomyces capsulatus]
MQRALSSTSRASVLSSAPTRAPVSRFRSAGLSLQQQRFAHKELKFGVEGRAALLKGIDTLAKAVCTTLGPKGRNVLIESSYGSPKITKDGVTVAKAVTLQDKFENLGARLLQDVASKTNEVAGDGTTTATVLARAIFSETVKNVAAGCNPMDLRRGIQAAVEAVVEYLQANKRDITTTEEIAQVATISANGDTHVGKLISNAMEKVGKEGVITVKDGKTIEDELEVTEGMRFDRGYVSPYFITDTKAQKVEFEKPLIVLSEKKISAVQDIIPALEASTTLRRPLVIIAEDIEGEALAVCILNKLRGQLQVAAVKVPGFGDNRKSILGDIGILTNATVFTDELDMKLEKATADMLGSTGSITITKEDTIILNGDGSKDSIAQRCEQIRGVIADPTTSDYEKEKLQERLAKLSGGVAVIKVGGASEVEVGEKKDRVVDALNATRAAVEEGILPGGGTALLKAAANGLASVKPTSSDQLRRISSLVSAITRPARTIVENAGLEGSVIVGKLTDEHASDFNRGFDSAKGEYVDMIASGIVDPLKVVRTALVDASGVASLLGTTEVAIVEAPEEKGPAGPPGGMGGMGGMGGGMF |
Structure Information |
PDB ID | closest is human at 57% amino acid sequence identity |
Quaternary structure | |
SCOP | NA |
CATH | NA |
TM Helix Prediction | no TM helices |
DisProt Annotation | Not in DisProt |
Predicted Disorder Regions | 1-33, 390-397, 569-590 |
Connections to Disease |
OMIM ID | |
Function 1 |
Function description | Hsp60 |
References for function | |
E.C. number | N/A |
Location of functional site(s) | |
Cellular location of function | mitochondrion |
Comments | |
Function 2 |
Function description | adhesin |
References for function | Long KH, Gomez FJ, Morris RE, Newman SL.Identification of heat shock protein 60 as the ligand on Histoplasma capsulatum that mediates binding to CD18 receptors on human macrophages. J Immunol. 2003 Jan 1;170(1):487-94.
PMID: 12496435 |
E.C. number | N/A |
Location of functional site(s) | |
Cellular location of function | cell surface |
Comments | |