Protein Information

General Information
MoonProt ID7
First appeared in release1.0
Name(s)Hsp60 60 kDa heat shock protein, mitochondrial Hsp60 kDa chaperonin Chaperonin 60 CPN60 Heat shock protein 60 HSP-60 HuCHA60 Mitochondrial matrix protein P1 P60 lymphocyte protein Gene Name: HSPD1
UniProt IDP10809 (CH60_HUMAN), Reviewed
GO termsGO:0002368 B cell cytokine production GO:0002755 MyD88-dependent toll-like receptor signaling pathway GO:0002842 positive regulation of T cell mediated immune response to tumor cell GO:0006200 ATP catabolic process GO:0006457 protein folding GO:0006458 'de novo' protein folding GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006986 response to unfolded protein GO:0008219 cell death GO:0019048 modulation by virus of host morphology or physiology GO:0032727 positive regulation of interferon-alpha production GO:0032729 positive regulation of interferon-gamma production GO:0032733 positive regulation of interleukin-10 production GO:0032735 positive regulation of interleukin-12 production GO:0032755 positive regulation of interleukin-6 production GO:0042026 protein refolding GO:0042100 B cell proliferation GO:0042110 T cell activation GO:0042113 B cell activation GO:0043032 positive regulation of macrophage activation GO:0043065 positive regulation of apoptotic process GO:0043066 negative regulation of apoptotic process GO:0044267 cellular protein metabolic process GO:0048291 isotype switching to IgG isotypes GO:0050821 protein stabilization GO:0050870 positive regulation of T cell activation GO:0051131 chaperone-mediated protein complex assembly GO:0051604 protein maturation GO:0000166 nucleotide binding GO:0001530 lipopolysaccharide binding GO:0002039 p53 binding GO:0003688 DNA replication origin binding GO:0003697 single-stranded DNA binding GO:0005515 protein binding GO:0005524 ATP binding GO:0016887 ATPase activity GO:0051082 unfolded protein binding GO:0051087 chaperone binding GO:0005615 extracellular space GO:0005737 cytoplasm GO:0005739 mitochondrion GO:0005743 mitochondrial inner membrane GO:0005759 mitochondrial matrix GO:0005769 early endosome GO:0005829 cytosol GO:0005886 plasma membrane GO:0005905 coated pit GO:0009986 cell surface GO:0030135 coated vesicle GO:0030141 secretory granule GO:0043231 intracellular membrane-bounded organelle GO:0046696 lipopolysaccharide receptor complex colocalizes_with GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex
Organisms for which functions have been demonstratedHomo sapiens and rat - PA-I, HepG2, HeLa, RAW 264, J774, Caco-2, COS cells
Sequence length
FASTA sequence>gi|129379|sp|P10809.2|CH60_HUMAN RecName: Full=60 kDa heat shock protein, mitochondrial; AltName: Full=60 kDa chaperonin; AltName: Full=Chaperonin 60; Short=CPN60; AltName: Full=Heat shock protein 60; Short=HSP-60; Short=Hsp60; AltName: Full=HuCHA60; AltName: Full=Mitochondrial matrix protein P1; AltName: Full=P60 lymphocyte protein; Flags: Precursor MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionHsp60 mitochondrial protein import, facilitate correct folding, promote refolding, prevent misfolding of proteins
References for function
E.C. numberN/A
Location of functional site(s)
Cellular location of functionmitochondrial matrix
Comments
Function 2
Function descriptionreceptor for HDL affinity for apolipoprotein apoA-II
References for functionBocharov AV, Vishnyakova TG, Baranova IN, Remaley AT, Patterson AP, Eggerman TL. Heat shock protein 60 is a high-affinity high-density lipoprotein binding protein. Biochem Biophys Res Commun. 2000 Oct 14. PMID: 11027668
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncell surface
Comments