| General Information |
| MoonProt ID | 705 |
| First appeared in release | 4.0 |
| Name(s) | Glutathione S-transferase A1 |
| UniProt ID | P08263 |
| GO terms | "GO:0004364 glutathione transferase activity
GO:0004601 peroxidase activity
GO:0004602 glutathione peroxidase activity
GO:0004769 steroid Delta-isomerase activity
GO:0005504 fatty acid binding
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016740 transferase activity
GO:0016853 isomerase activity
GO:0140104 molecular carrier activity
GO:0006629 lipid metabolic process
GO:0006693 prostaglandin metabolic process
GO:0006749 glutathione metabolic process
GO:0006805 xenobiotic metabolic process
GO:0030855 epithelial cell differentiation
GO:0042167 heme catabolic process
GO:0043651 linoleic acid metabolic process
GO:0098869 cellular oxidant detoxification
GO:1901687 glutathione derivative biosynthetic process
GO:0005829 cytosol
GO:0005737 cytoplasm
GO:0070062 extracellular exosome" |
| Organisms for which functions have been demonstrated | Homo sapiens (Human) |
| Sequence length | 222.0 |
| FASTA sequence | >sp|P08263|GSTA1_HUMAN Glutathione S-transferase A1 OS=Homo sapiens OX=9606 GN=GSTA1 PE=1 SV=3 MAEKPKLHYFNARGRMESTRWLLAAAGVEFEEKFIKSAEDLDKLRNDGYLMFQQVPMVEI DGMKLVQTRAILNYIASKYNLYGKDIKERALIDMYIEGIADLGEMILLLPVCPPEEKDAK LALIKEKIKNRYFPAFEKVLKSHGQDYLVGNKLSRADIHLVELLYYVEELDSSLISSFPL LKALKTRISNLPTVKKFLQPGSPRKPPMDEKSLEEARKIFRF |
| Structure Information |
| PDB ID | 1GSD 1GSE 1GSF 1GUH 1K3L 1K3O 1K3Y 1LBK 1PKW 1PKZ 1PL1 1PL2 1USB 1XWG 1YDK 2R3X 2R6K 3I69 3I6A 3IK9 3KTL 3L0H 3Q74 3U6V 3ZFB 3ZFL 4HJ2 5JCU 5LCZ 5LD0 6ATO 6ATP 6ATQ 6ATR 6YAW 7BIB 7BIC 8BHC 8BHE" |
| Quaternary structure | Homodimer or heterodimer of GSTA1 and GSTA2 |
| SCOP | 80303291K3Y A
80303281K3Y A
80427081K3Y A
80427071K3Y A |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | DP01506 |
| Predicted Disorder Regions | Predicted disorder at N terminus (aa 1-7), and C terminus (aa 197-222) |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | enzyme, glutathione S-transferase |
| References for function | Pettersson PL, Mannervik B. The role of glutathione in the isomerization of delta 5-androstene-3,17-dione catalyzed by human glutathione transferase A1-1. J Biol Chem. 2001 Apr 13;276(15):11698-704. doi: 10.1074/jbc.M009146200. Epub 2001 Jan 10. PMID: 11152686. |
| E.C. number | EC:2.5.1.18 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | enzyme, steroid isomerase |
| References for function | Pettersson PL, Mannervik B. The role of glutathione in the isomerization of delta 5-androstene-3,17-dione catalyzed by human glutathione transferase A1-1. J Biol Chem. 2001 Apr 13;276(15):11698-704. doi: 10.1074/jbc.M009146200. Epub 2001 Jan 10. PMID: 11152686. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |