General Information |
MoonProt ID | 73 |
First appeared in release | 1.0 |
Name(s) | Hsp60
GroEL
60 kDa chaperonin
Protein Cpn60
Gene Name: groL
|
UniProt ID | P31294 (CH60_HAEDU), Reviewed |
GO terms | GO:0006457 protein folding
GO:0042026 protein refolding
GO:0044267 cellular protein metabolic process
GO:0000166 nucleotide binding
GO:0005524 ATP binding
GO:0051082 unfolded protein binding
GO:0005737 cytoplasm |
Organisms for which functions have been demonstrated | Haemophilus ducreyi (Gram negative bacterium) |
Sequence length | 547 |
FASTA sequence | >gi|148892|gb|AAA24961.1| heat shock protein [Haemophilus ducreyi]
MAIKDVKFGNDARVKMLKGVNILADAVKVTLGPKGRKVVLDKAYGAPTITKDGVSVAREIELEDKFENMGAQMVKEVASKANDVAGDGTTTATVLAQSIVSEGLRAVAAGMNPMDLKRGIDKAVAAVVEELKAISKPCETSKEIEQVGTISANSDETVGKLIAQAMEKVGKEGVITVEDGTGLDDALDVVEGMQFDRGYLSPYFINKPEAGTVELDNPYIILVDKKISNIREILPVLEAVAKAGKPLLIIAEDVEGEALATLVVNTMRGIVKVAAVKAPGFGDRRKAMLQDIAILTAGTVISEEIGMELEKATLEELGQAKRVVITKDNTTIIDGIGDEAQIKARVVQIRQQIEDSTSDYDKEKLQERVAKLAGGVAVIKVGAATEVAMKEKKDRVDDALHATRAAVEEGIVPGGGVALVRAANKVSATLTGDNEEQNVGIKLALRAMEAPLRQIVENSGEDASVVARDVKDGSGNFGYNATTEEYGDMLEMGILDPTKVTRSALQFAASIAGLMITTECMITDLPKEDKLDAQAAMGGMGGMGGMM |
Structure Information |
PDB ID | closest is E. coli at 85% amino acid sequence identity |
Quaternary structure | |
SCOP | NA |
CATH | NA |
TM Helix Prediction | no TM helices |
DisProt Annotation | Not in DisProt |
Predicted Disorder Regions | 1-10, 354-357, 529-547 |
Connections to Disease |
OMIM ID | |
Function 1 |
Function description | Hsp60, GroEL, Prevents misfolding and promotes the refolding and proper assembly of unfolded proteins |
References for function | |
E.C. number | N/A |
Location of functional site(s) | |
Cellular location of function | cytoplasm |
Comments | |
Function 2 |
Function description | adhesin - to glycosphinngolipids |
References for function | Pantzar M, Teneberg S, Lagerg?rd T. Binding of Haemophilus ducreyi to carbohydrate receptors is mediated by the 58.5-kDa GroEL heat shock protein. Microbes Infect. 2006 Aug;8(9-10):2452-8.
PMID: 16880000 |
E.C. number | N/A |
Location of functional site(s) | |
Cellular location of function | cell surface |
Comments | |