General Information |
MoonProt ID | 74 |
First appeared in release | 1.0 |
Name(s) | Hsp60
GroEL
60 kDa chaperonin
Protein Cpn60
Gene Name: groL
|
UniProt ID | F7SCR2 (F7SCR2_LACJH) |
GO terms | GO:0006457 protein folding
GO:0042026 protein refolding
GO:0044267 cellular protein metabolic process
GO:0000166 nucleotide binding
GO:0005524 ATP binding
GO:0051082 unfolded protein binding
GO:0005737 cytoplasm |
Organisms for which functions have been demonstrated | Lactobacillus johnsonii La1 (NCC 533) (Gram positive bacterium) |
Sequence length | 543 |
FASTA sequence | >gi|45645206|sp|Q9KJ23.2|CH60_LACJO RecName: Full=60 kDa chaperonin; AltName: Full=GroEL protein; AltName: Full=Protein Cpn60
MAKEIKFSENARHSLLKGVDKLADTVKTTLGPKGRNVVLEKSYGAPDITNDGVTIAKSIELENHFENMGAKLVSEAAQKTNDIAGDGTTTATVLTQAIVREGMKNVTAGANPVGIRRGIETATKAAVDELHKISHKVSTKDEIAQVASVSSASTEVGNLIADAMEKVGHDGVITIEESKGIDTELSVVEGMQFDRGYLSQYMVTDNDKMEADLDNPYILITDKKISNIQDILPLLQEIVQQGKSLLIIADDVDGEALPTLVLNKIRGTFNVVAVKAPGFGDRRKAMLEDIAILTGGTVISSDLGLELKDTKIDQLGKAGKVTVTKDSTTIVEGAGSKEAIAERVDQIKKQIADTTSDFDREKLQERLAKLAGGVAVIKVGAATETELKERKYRIEDALNATRAAVEEGYVAGGGTALVDVMKSIQGTVKGDSEDAETGVKIVMKALGAPVRQIAENAGKDGAVILDHLEHEDPEVGYNAATNKWENMVKAGIIDPTKVTRSALQNAASIAALLLTTEAVVADAPEDDKNQAPAAPNPGMGMGM |
Structure Information |
PDB ID | closest is Thermus at 60% amino acid sequence identity |
Quaternary structure | |
SCOP | NA |
CATH | NA |
TM Helix Prediction | no TM helices |
DisProt Annotation | Not in DisProt |
Predicted Disorder Regions | |
Connections to Disease |
OMIM ID | |
Function 1 |
Function description | Hsp60, GroEL, Prevents misfolding of proteins, promotes the refolding and correct assembly of unfolded proteins |
References for function | |
E.C. number | N/A |
Location of functional site(s) | |
Cellular location of function | cytoplasm |
Comments | |
Function 2 |
Function description | adhesin
binds to mucins and epithelial cells |
References for function | Bergonzelli GE, Granato D, Pridmore RD, MarvinGuy LF, Donnicola D, Corth?syTheulaz IE. GroEL of Lactobacillus johnsonii La1 (NCC 533) is cell surface associated: potential role in interactions with the host and the gastric pathogen Helicobacter pylori. Infect Immun. 2006 Jan;74(1):425-34.
PMID: 16368998 |
E.C. number | N/A |
Location of functional site(s) | |
Cellular location of function | cell surface |
Comments | |