Protein Information

General Information
MoonProt ID74
First appeared in release1.0
Name(s)Hsp60 GroEL 60 kDa chaperonin Protein Cpn60 Gene Name: groL
UniProt IDF7SCR2 (F7SCR2_LACJH)
GO termsGO:0006457 protein folding GO:0042026 protein refolding GO:0044267 cellular protein metabolic process GO:0000166 nucleotide binding GO:0005524 ATP binding GO:0051082 unfolded protein binding GO:0005737 cytoplasm
Organisms for which functions have been demonstratedLactobacillus johnsonii La1 (NCC 533) (Gram positive bacterium)
Sequence length543
FASTA sequence>gi|45645206|sp|Q9KJ23.2|CH60_LACJO RecName: Full=60 kDa chaperonin; AltName: Full=GroEL protein; AltName: Full=Protein Cpn60 MAKEIKFSENARHSLLKGVDKLADTVKTTLGPKGRNVVLEKSYGAPDITNDGVTIAKSIELENHFENMGAKLVSEAAQKTNDIAGDGTTTATVLTQAIVREGMKNVTAGANPVGIRRGIETATKAAVDELHKISHKVSTKDEIAQVASVSSASTEVGNLIADAMEKVGHDGVITIEESKGIDTELSVVEGMQFDRGYLSQYMVTDNDKMEADLDNPYILITDKKISNIQDILPLLQEIVQQGKSLLIIADDVDGEALPTLVLNKIRGTFNVVAVKAPGFGDRRKAMLEDIAILTGGTVISSDLGLELKDTKIDQLGKAGKVTVTKDSTTIVEGAGSKEAIAERVDQIKKQIADTTSDFDREKLQERLAKLAGGVAVIKVGAATETELKERKYRIEDALNATRAAVEEGYVAGGGTALVDVMKSIQGTVKGDSEDAETGVKIVMKALGAPVRQIAENAGKDGAVILDHLEHEDPEVGYNAATNKWENMVKAGIIDPTKVTRSALQNAASIAALLLTTEAVVADAPEDDKNQAPAAPNPGMGMGM
Structure Information
PDB IDclosest is Thermus at 60% amino acid sequence identity
Quaternary structure
SCOPNA
CATHNA
TM Helix Predictionno TM helices
DisProt AnnotationNot in DisProt
Predicted Disorder Regions
Connections to Disease
OMIM ID
Function 1
Function descriptionHsp60, GroEL, Prevents misfolding of proteins, promotes the refolding and correct assembly of unfolded proteins
References for function
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionadhesin binds to mucins and epithelial cells
References for functionBergonzelli GE, Granato D, Pridmore RD, MarvinGuy LF, Donnicola D, Corth?syTheulaz IE. GroEL of Lactobacillus johnsonii La1 (NCC 533) is cell surface associated: potential role in interactions with the host and the gastric pathogen Helicobacter pylori. Infect Immun. 2006 Jan;74(1):425-34. PMID: 16368998
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncell surface
Comments