Protein Information

General Information
MoonProt ID77
First appeared in release1.0
Name(s)Hsp60 GroEL 60 kDa chaperonin Protein Cpn60 Gene Name: groL
UniProt IDP0A1D3
GO termsGO:0006457 protein folding GO:0042026 protein refolding GO:0044267 cellular protein metabolic process GO:0000166 nucleotide binding GO:0005524 ATP binding GO:0051082 unfolded protein binding GO:0005737 cytoplasm
Organisms for which functions have been demonstratedSalmonella typhimurium (Gram negative bacterium)
Sequence length548 aa
FASTA sequence>sp|P0A1D3|CH60_SALTY 60 kDa chaperonin OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=groL PE=3 SV=2 MAAKDVKFGNDARVKMLRGVNVLADAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAREIELEDKFENMGAQMVKEVASKANDAAGDGTTTATVLAQSIITEGLKAVAAGMNPMDLKRGIDKAVAAAVEELKALSVPCSDSKAIAQVGTISANSDETVGKLIAEAMDKVGKEGVITVEDGTGLQDELDVVEGMQFDRGYLSPYFINKPETGAVELESPFILLADKKISNIREMLPVLEAVAKAGKPLLIIAEDVEGEALATLVVNTMRGIVKVAAVKAPGFGDRRKAMLQDIATLTGGTVISEEIGMELEKATLEDLGQAKRVVINKDTTTIIDGVGEEAAIQGRVAQIRQQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGVVAGGGVALIRVASKIADLKGQNEDQNVGIKVALRAMEAPLRQIVLNCGEEPSVVANTVKGGDGNYGYNAATEEYGNMIDMGILDPTKVTRSALQYAASVAGLMITTECMVTDLPKSDAPDLGAAGGMGGMGGMGGMM
Structure Information
PDB IDclosest is E. coli at 99% amino acid sequence identity
Quaternary structure
SCOPNA
CATHNA
TM Helix Predictionno TM helices
DisProt AnnotationNot in DisProt
Predicted Disorder Regions1-10, 82-85, 354-360, 528-548
Connections to Disease
OMIM ID
Function 1
Function descriptionchaperonin, Prevents misfolding of proteins, promotes the refolding and proper assembly of unfolded proteins
References for function
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionadhesin
References for functionEnsgraber M, Loos M. A 66-kilodalton heat shock protein of Salmonella typhimurium is responsible for binding of the bacterium to intestinal mucus. Infect Immun. 1992 Aug;60(8):3072-8. PMID: 1639475
E.C. numberN/A
Location of functional site(s)
Cellular location of functionsecreted
Comments