| General Information |
| MoonProt ID | 78 |
| First appeared in release | 1.0 |
| Name(s) | Hsp60
GroEL
60 kDa chaperonin
Protein Cpn60
Gene Name: groL
|
| UniProt ID | Q9KKF0 (CH60_CLODI), Reviewed |
| GO terms | GO:0006457 protein folding
GO:0042026 protein refolding
GO:0044267 cellular protein metabolic process
GO:0000166 nucleotide binding
GO:0005524 ATP binding
GO:0051082 unfolded protein binding
GO:0005737 cytoplasm |
| Organisms for which functions have been demonstrated | Clostridium difficile (can cause diarrhea) |
| Sequence length | 540 |
| FASTA sequence | >gi|8886080|gb|AAF80372.1|AF159449_1 heat shock protein GroEL [[Clostridium] difficile]
MAKEIKFSEETRRALEAGVNKLADTVKVTLGPKGRNVILDKKFGSPLITNDGVTIAKEIELEDRFENMGAQLVKEVATKTNDVAGDGTTTATVLAQAIIREGLKNVTAGANPILLRKGIQKAVTVAVEELKNQSRIVETQEAISQVASISAGDEEVGKLIAEAMEIVGKDGVITVEESQTMNTELDAVEGMQFDRGFVSAYMVTDVDKMEAVLKDPYILITDKKISNIQELLPVVEQIVQQGKKLLIIAEDVEGEALSTLVVNKLRGTFDVVAVKAPGFGDRRKEMLQDIAILTGAQVISEELGYDLKEADLSMLGRASSVKVTKENTTIVDGSGDKKSIEDRVTQIKHQVEQTTSDFDREKLMERLAKLAGGVAVVKVGAATEVELKERKLRIEDALNATRAAVEEGIVAGGGTAFVSVIPAIGTLIESLEGEVKLGAQIVKKALEEPLRQIAINAGLEGAVIVQNVVNSEAETGFDALNEKYVNMIEAGIVDPTKVSRSALQNAASIASTFLTTEAAVADLPEKEDAGMPGTGMDGMY |
| Structure Information |
| PDB ID | closest is Thermus at 65% amino acid sequence identity |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-10, 351-358, 526-540 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | chaperonin, Prevents protein misfolding, promotes the refolding and proper assembly of unfolded proteins |
| References for function | |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | adhesin |
| References for function | Hennequin C, Porcheray F, WaligoraDupriet A, Collignon A, Barc M, Bourlioux P, Karjalainen T. GroEL (Hsp60) of Clostridium difficile is involved in cell adherence. Microbiology. 2001 Jan;147(Pt 1):87-96.
PMID: 11160803 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |