| General Information |
| MoonProt ID | 79 |
| First appeared in release | 1.0 |
| Name(s) | Hsp60
HspB
60 kDa chaperonin
GroEL protein
Protein Cpn60
Gene Name: hspB |
| UniProt ID | Q8RNU2 (Q8RNU2_HELPX), Unreviewed |
| GO terms | GO:0006457 protein folding
GO:0006950 response to stress
GO:0042026 protein refolding
GO:0044267 cellular protein metabolic process
GO:0000166 nucleotide binding
GO:0005524 ATP binding
GO:0051082 unfolded protein binding
GO:0005737 cytoplasm |
| Organisms for which functions have been demonstrated | Helicobacter pylori (H. pylori strain TK1029) (causes peptic ulcers and gastritis) |
| Sequence length | 546 |
| FASTA sequence | >gi|19338968|gb|AAL86900.1|AF479030_1 heat shock protein B subunit [Helicobacter pylori]
MAKEIKFSDSARNLLFEGVRQLHDAVKVTMGPRGRNVLIQKSYGAPSITKDGVSVAKEIELSCPVANMGAQLVKEVASKTADAAGDGTTTATVLAYSIFKEGLRNITAGANPIEVKRGMDKAAEAIINELKKASKKVGGKEEITQVATISANSDHNIGKLIADAMEKVGKDGVITVEEAKGIEDELDVVEGMQFDRGYLSPYFVTNAEKMTAQLDNAYILLTDKKISSMKDILPLLEKTMKEGKPLLIIAEDIEGEALTTLVVNKLRGVLNIAAVKAPGFGDRRKEMLKDIAILTGGQVISEELGLSLENAEVEFLGKAGRIVIDKDNTTIVDGKGHSDDVKDRVAQIKTQIASTTSDYDKEKLQERLAKLSGGVAVIKVGAASEVEMKEKKDRVDDALSATKAAVEEGIVIGGGAALIRAAQKVHLNLHDDEKVGYEIIMRAIKAPLAQIAINAGYDGGVVVNEVEKHEGHFGFNASNGKYVDMFKEGIIDPLKVERIALQNAVSVSSLLLTTEATVHEIKEEKAAPAMPDMGGMGGMGGMGGMM |
| Structure Information |
| PDB ID | closest is Chlorobaculum at 66% amino acid sequence identity |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-10, 353-358, 525-546 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | chaperonin, Prevents protein misfolding, promotes the refolding and proper assembly of unfolded proteins |
| References for function | |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | adhesin - to host cells |
| References for function | Kamiya S, Yamaguchi H, Osaki T, Taguchi H. A virulence factor of Helicobacter pylori: role of heat shock protein in mucosal inflammation after H. pylori infection. J Clin Gastroenterol. 1998;27 Suppl 1:S35-9.
PMID: 9872496
Yamaguchi H, Osaki T, Kurihara N, Taguchi H, Hanawa T, Yamamoto T, Kamiya S. Heat-shock protein 60 homologue of Helicobacter pylori is associated with adhesion of H. pylori to human gastric epithelial cells. J Med Microbiol. 1997 Oct;46(10):825-31.
PMID: 9364138 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |