| General Information |
| MoonProt ID | 80 |
| First appeared in release | 1.0 |
| Name(s) | Hsp65
Cpn60.2
GroEL2
groEL
60 kDa chaperonin
GroEL protein
Gene Name: groL
|
| UniProt ID | A0A0H3LCC3 |
| GO terms | GO:0006457 protein folding
GO:0042026 protein refolding
GO:0044267 cellular protein metabolic process
GO:0000166 nucleotide binding
GO:0005524 ATP binding
GO:0051082 unfolded protein binding
GO:0005737 cytoplasm |
| Organisms for which functions have been demonstrated | Mycobacterium tuberculosis (mycobacterium, causes tuberculosis) |
| Sequence length | 540 aa |
| FASTA sequence | >tr|A0A0H3LCC3|A0A0H3LCC3_MYCTE 60 kDa chaperonin OS=Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman) GN=groEL PE=3 SV=1
MAKTIAYDEEARRGLERGLNALADAVKVTLGPKGRNVVLEKKWGAPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGLRNVAAGANPLGLKRGIEKAVEKVTETLLKGAKEVETKEQIAATAAISAGDQSIGDLIAEAMDKVGNEGVITVEESNTFGLQLELTEGMRFDKGYISGYFVTDPERQEAVLEDPYILLVSSKVSTVKDLLPLLEKVIGAGKPLLIIAEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAMLQDMAILTGGQVISEEVGLTLENADLSLLGKARKVVVTKDETTIVEGAGDTDAIAGRVAQIRQEIENSDSDYDREKLQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVRNAKAAVEEGIVAGGGVTLLQAAPTLDELKLEGDEATGANIVKVALEAPLKQIAFNSGLEPGVVAEKVRNLPAGHGLNAQTGVYEDLLAAGVADPVKVTRSALQNAASIAGLFLTTEAVVADKPEKEKASVPGGGDMGGMDF
|
| Structure Information |
| PDB ID | 3RTK |
| Quaternary structure | |
| SCOP | NA |
| CATH | 1.10.560.10, 3.30.260.10, 3.50.7.10 |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-11, 352-357, 524-540 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | chaperonin, Prevents protein misfolding, promotes the refolding and proper assembly of unfolded proteins |
| References for function | |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | adhesin to CD43 on macrophage surface |
| References for function | Hickey TB, Thorson LM, Speert DP, Daff M, Stokes RW. Mycobacterium tuberculosis Cpn60.2 and DnaK are located on the bacterial surface, where Cpn60.2 facilitates efficient bacterial association with macrophages. Infect Immun. 2009 Aug;77(8):3389-401. doi: 10.1128/IAI.00143-09. Epub 2009 May 26.
PMID: 19470749 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |