| General Information |
| MoonProt ID | 84 |
| First appeared in release | 1.0 |
| Name(s) | Peroxisomal catalase
CTA1
Gene Name: CTA1
|
| UniProt ID | O13289 (CATA_CANAL), Reviewed |
| GO terms | GO:0006979 response to oxidative stress
GO:0009267 cellular response to starvation
GO:0009405 pathogenesis
GO:0030447 filamentous growth
GO:0036170 filamentous growth of a population of unicellular organisms in response to starvation
GO:0036171 filamentous growth of a population of unicellular organisms in response to chemical stimulus
GO:0042542 response to hydrogen peroxide
GO:0042743 hydrogen peroxide metabolic process
GO:0042744 hydrogen peroxide catabolic process
GO:0042744 hydrogen peroxide catabolic process
GO:0051701 interaction with host
GO:0055114 oxidation-reduction process
GO:0070301 cellular response to hydrogen peroxide
GO:0004096 catalase activity
GO:0004601 peroxidase activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0020037 heme binding
GO:0046872 metal ion binding
GO:0005777 peroxisome
GO:0009277 fungal-type cell wall |
| Organisms for which functions have been demonstrated | Candida albicans (yeast, a fungi, can cause candiadiasis) |
| Sequence length | 487 |
| FASTA sequence | >gi|21431745|sp|O13289.4|CATA_CANAL RecName: Full=Peroxisomal catalase
MAPTFTNSNGQPIPEPFATQRVGQHGPLLLQDFNLIDSLAHFDRERIPERVVHAKGSGAYGVFEVTDDITDICAAKFLDTVGKKTRIFTRFSTVGGELGSADTARDPRGFATKIYTEEGNLDLVYNNTPVFFIRDPSKFPHFIHTQKRNPETHLKDANMFWDYLTSNEESIHQVMVLFSDRGTPASYREMNGYSGHTYKWSNKKGEWFYVQVHFISDQGIKTLNNEEAGALAGSNPDYAQEDLFKNIAAGNYPSWTAYIQTMTEAEAKEAEFSVFDLTKVWPHRKYPMRRFGKFTLNENPENYFAEVEQAAFSPAHTVPYMEPSADPVLQSRLFSYADTHRPHRLGTNYTQIPVNCPVTGAVFNPHSRDGAMTVNGNLGSHPNYLASDKPVEFKQFSSFQEDQEVWNGAATPFHWKATPADFKQAQELWKVLKRYPNQQEHLAHNIAVHAAGADAAIQDRVFAYFGKVSQDLADAIKKEVLELSPRK
|
| Structure Information |
| PDB ID | closest is Kluyveromyces at 71% amino acid sequence identity |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-4, 332-333 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | Peroxisomal catalase (CTA1), protect cells from the toxic effects of hydrogen peroxide
2 H2O2 => O2 + 2 H2O
|
| References for function | |
| E.C. number | 1.11.1.6 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | plasminogen binding |
| References for function | Crowe, J.D. et al. (2003) Candida albicans binds human plasminogen:
identification of eight plasminogen-binding proteins. Mol Microbiol. 2003 Mar;47(6):1637-51.
PMID: 12622818 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |