General Information |
MoonProt ID | 85 |
First appeared in release | 1.0 |
Name(s) | Phosphoglycerate kinase
Gene Name: pgk
|
UniProt ID | Q8DXT0 |
GO terms | GO:0006096 glycolysis
GO:0016310 phosphorylation
GO:0000166 nucleotide binding
GO:0004618 phosphoglycerate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0005737 cytoplasm |
Organisms for which functions have been demonstrated | Streptococcus agalactiae (GBS = group B Streptococcus, strain NCS13) (Gram positive bacterium) |
Sequence length | 398 aa |
FASTA sequence | >sp|Q8DXT0|PGK_STRA5 Phosphoglycerate kinase OS=Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R) GN=pgk PE=3 SV=1
MAKLTVKDVDLKGKKVLVRVDFNVPLKDGVITNDNRITAALPTIKYIIEQGGRAILFSHLGRVKEEADKEGKSLAPVAADLAAKLGQDVVFPGVTRGAKLEEAINALEDGQVLLVENTRFEDVDGKKESKNDEELGKYWASLGDGIFVNDAFGTAHRAHASNVGISANVEKAVAGFLLENEIAYIQEAVETPERPFVAILGGSKVSDKIGVIENLLEKADKVLIGGGMTYTFYKAQGIEIGNSLVEEDKLDVAKDLLEKSNGKLILPVDSKEANAFAGYTEVRDTEGEAVSEGFLGLDIGPKSIAKFDEALTGAKTVVWNGPMGVFENPDFQAGTIGVMDAIVKQPGVKSIIGGGDSAAAAINLGRADKFSWISTGGGASMELLEGKVLPGLAALTEK
|
Structure Information |
PDB ID | closest is Streptococcus pneumonia with 99% amino acid sequence identity |
Quaternary structure | |
SCOP | NA |
CATH | NA |
TM Helix Prediction | no TM helices |
DisProt Annotation | Not in DisProt |
Predicted Disorder Regions | 1-2, 66-69, 125-129, 397-398 |
Connections to Disease |
OMIM ID | |
Function 1 |
Function description | Phosphoglycerate kinase
ADP + 1,3-bisphosphoglycerate => ATP + 3-phosphoglycerate
Carbohydrate degradation, glycolysis |
References for function | |
E.C. number | 2.7.2.3 |
Location of functional site(s) | |
Cellular location of function | cytoplasm |
Comments | |
Function 2 |
Function description | plasminogen binding |
References for function | Boone TJ, Burnham CA, Tyrrell GJ. Binding of group B streptococcal phosphoglycerate kinase to plasminogen and actin.Microb Pathog. 2011 Oct;51(4):255-61. doi: 10.1016/j.micpath.2011.06.005. Epub 2011 Jun 28. PMID: 21729749
|
E.C. number | N/A |
Location of functional site(s) | |
Cellular location of function | cell surface |
Comments | |