| General Information |
| MoonProt ID | 86 |
| First appeared in release | 1.0 |
| Name(s) | Phosphoglycerate kinase
Gene Name: pgk
|
| UniProt ID | Q8DQX8 (PGK_STRR6), Reviewed |
| GO terms | GO:0006096 glycolysis
GO:0016310 phosphorylation
GO:0000166 nucleotide binding
GO:0004618 phosphoglycerate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0005737 cytoplasm |
| Organisms for which functions have been demonstrated | Streptococcus pneumoniae (Gram positive bacterium) |
| Sequence length | 398 |
| FASTA sequence | >sp|Q8DQX8|PGK_STRR6 Phosphoglycerate kinase OS=Streptococcus pneumoniae (strain ATCC BAA-255 / R6) GN=pgk PE=1 SV=1
MAKLTVKDVDLKGKKVLVRVDFNVPLKDGVITNDNRITAALPTIKYIIEQGGRAILFSHLGRVKEESDKAGKSLAPVAADLAAKLGQDVVFPGVTRGAELEAAINALEDGQVLLVENTRYEDVDGKKESKNDPELGKYWASLGDGIFVNDAFGTAHRAHASNVGISANVEKAVAGFLLENEIAYIQEAVETPERPFVAILGGSKVSDKIGVIENLLEKADKVLIGGGMTYTFYKAQGIEIGNSLVEEDKLDVAKALLEKANGKLILPVDSKEANAFAGYTEVRDTEGEAVSEGFLGLDIGPKSIAKFDEALTGAKTVVWNGPMGVFENPDFQAGTIGVMDAIVKQPGVKSIIGGGDSAAAAINLGRADKFSWISTGGGASMELLEGKVLPGLAALTEK |
| Structure Information |
| PDB ID | 3ZLB |
| Quaternary structure | |
| SCOP | NA |
| CATH | 3.40.50.1260 |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-2, 67-68, 125-129, 397-398 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | Phosphoglycerate kinase, enzyme
ADP + 1,3-bisphosphoglycerate => ATP + glycerate-3-phosphate
Carbohydrate degradation, glycolysis |
| References for function | |
| E.C. number | 2.7.2.3 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | plasminogen binding |
| References for function | Fulde M, BernardoGarc?a N, Rohde M, Nachtigall N, Frank R, Preissner KT, Klett J, Morreale A, Chhatwal GS, Hermoso JA, Bergmann S. Pneumococcal phosphoglycerate kinase interacts with plasminogen and its tissue activator. Thromb Haemost. 2014 Mar 3;111(3):401-16. doi: 10.1160/TH13-05-0421. Epub 2013 Nov 7.
PMID: 24196407 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |