| General Information |
| MoonProt ID | 88 |
| First appeared in release | 1.0 |
| Name(s) | Phosphoglycerate kinase
PGK1
Gene Name: pgk
|
| UniProt ID | A0A0G7HBY7 |
| GO terms | GO:0006096 glycolysis
GO:0016310 phosphorylation
GO:0000166 nucleotide binding
GO:0004618 phosphoglycerate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0005737 cytoplasm |
| Organisms for which functions have been demonstrated | Streptococcus - oral streptococci (S. anginosus and S. oralis) (Gram positive bacterium) |
| Sequence length | 396 aa |
| FASTA sequence | >tr|A0A0G7HBY7|A0A0G7HBY7_9STRE Phosphoglycerate kinase OS=Streptococcus equi subsp. equi GN=pgk_1 PE=3 SV=1
MAKKIVTDLELKGKTVLVRADFNVPMKDGEITDDNRIVQAIPTIKYIIEQGGKVVLFSHLGKVKEESDKAALTLKPVANALTEKLGEEVTFVPETRGETLEQSVKDLNEGDVLLVENTRFEDVDGKKESKNDPELGKYWASLGDVFVNDAFGTAHREHASNVGIASNLETVAGFLMEKEIKYIGGVVENPDKPVVAILGGAKVSDKIGVITNLLKIADKVLIGGGMSYTFFKAQGKEIGLSLLEKDKVDFAKELLDRAGDQIVLPVDCKVAKEFSNDAEITEVSVDDIPADQEAMDIGPKSVELFKEQLQGAHTVVWNGPMGVFELSNFAKGTIGVCEAIAELKDANTIIGGGDSAAAAISLGYGDDFSHISTGGGASLEYLEGKELPGVVAIANK
|
| Structure Information |
| PDB ID | closest is staphylococcus at 81% amino acid sequence identity |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | Phosphoglycerate kinase, enzyme
ADP + 1,3-bisphosphoglycerate => ATP + 3-phospho-D-glycerate
Carbohydrate degradation, glycolysis |
| References for function | |
| E.C. number | 2.7.2.3 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | plasminogen binding |
| References for function | Kinnby B, Booth NA, Svensater G. Plasminogen binding by oral streptococci from dental plaque and inflammatory lesions.Microbiology. 2008 Mar;154(Pt 3):924-31. doi: 10.1099/mic.0.2007/013235-0. PMID: 18310038 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |