| General Information |
| MoonProt ID | 92 |
| First appeared in release | 1.0 |
| Name(s) | Pyruvate dehydrogenase (E1 beta subunit, PDH-B)
Pyruvate dehydrogenase E1 component subunit beta
Gene Name: pdhB
|
| UniProt ID | P75391 (ODPB_MYCPN), Reviewed |
| GO terms | GO:0006096 glycolysis
GO:0008152 metabolic process
GO:0055114 oxidation-reduction process
GO:0003824 catalytic activity
GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity GO:0016491 oxidoreductase activity |
| Organisms for which functions have been demonstrated | Mycoplasma pneumoniae |
| Sequence length | 327 |
| FASTA sequence | >sp|P75391|ODPB_MYCPN Pyruvate dehydrogenase E1 component subunit beta OS=Mycoplasma pneumoniae (strain ATCC 29342 / M129) GN=pdhB PE=3 SV=1
MSKTIQANNIEALGNAMDLALERDPNVVLYGQDAGFEGGVFRATKGLQKKYGEERVWDCPIAEAAMAGIGVGAAIGGLKPIVEIQFSGFSFPAMFQIFTHAARIRNRSRGVYTCPIIVRMPMGGGIKALEHHSETLEAIYGQIAGLKTVMPSNPYDTKGLFLAAVESPDPVVFFEPKKLYRAFRQEIPADYYTVPIGQANLISQGNNLTIVSYGPTMFDLINMVYGGELKDKGIELIDLRTISPWDKETVFNSVKKTGRLLVVTEAAKTFTTSGEIIASVTEELFSYLKAAPQRVTGWDIVVPLARGEHYQFNLNARILEAVNQLLK
|
| Structure Information |
| PDB ID | closest is Pseudonomas with 43% amino acid sequence identity |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-7, 327 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | Pyruvate dehydrogenase, enzyme
The pyruvate dehydrogenase complex catalyzes the overall conversion pyruvate => acetyl-CoA and CO2.
Pyruvate dehydrogenase (E1) is one of the enzyme components of the complex
|
| References for function | |
| E.C. number | 1.2.4.1 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | fibrinogen binding |
| References for function | Dallo SF, Kannan TR, Blaylock MW, Baseman JB. Elongation factor Tu and E1 beta subunit of pyruvate dehydrogenase complex act as fibronectin binding proteins in Mycoplasma pneumoniae. Mol Microbiol. 2002 Nov. PMID: 12421310 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |