| General Information |
| MoonProt ID | 105 |
| First appeared in release | 4.0 |
| Name(s) | 5-aminolevulinate synthase, non-specific, mitochondrial |
| UniProt ID | Q8VC19 |
| GO terms | GO:0003870 5-aminolevulinate synthase activity
GO:0016740 transferase activity
GO:0016746 acyltransferase activity
GO:0030170 pyridoxal phosphate binding
GO:0042802 identical protein binding
GO:0001666 response to hypoxia
GO:0006778 porphyrin-containing compound metabolic process
GO:0006782 protoporphyrinogen IX biosynthetic process
GO:0006783 heme biosynthetic process
GO:0006784 heme A biosynthetic process
GO:0006785 heme B biosynthetic process
GO:0009410 response to xenobiotic stimulus
GO:0009635 response to herbicide
GO:0010045 response to nickel cation
GO:0031667 response to nutrient levels
GO:0032025 response to cobalt ion
GO:0032869 cellular response to insulin stimulus
GO:0033014 tetrapyrrole biosynthetic process
GO:0034698 response to gonadotropin
GO:0042541 hemoglobin biosynthetic process
GO:0045471 response to ethanol
GO:0051591 response to cAMP
GO:0070541 response to platinum ion
GO:1903412 response to bile acid
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0005829 cytosol |
| Organisms for which functions have been demonstrated | Mus musculus (mouse) |
| Sequence length | 642 |
| FASTA sequence | >sp|Q8VC19|HEM1_MOUSE 5-aminolevulinate synthase, non-specific, mitochondrial OS=Mus musculus OX=10090 GN=Alas1 PE=1 SV=2
METVVRRCPFLSRVPQAFLQKAGKSLLFYAQNCPKMMEVGAKPAPRTLSTSAVHCQQVKE
TPPANEKEKTAKAAVQQAPDESQMAQTPDGTQLPSGHPSPATSQGSGSKCPFLAAQLSQT
GSSVFRKASLELQEDVQEMHAVRKEAAQSPVPPSLVNVKTDGEDPSRLLKNFQDIMRKQR
PERVSHLLQDNLPKSVSTFQYDHFFEKKIDEKKNDHTYRVFKTVNRRAQIFPMADDYTDS
LITKKQVSVWCSNDYLGMSRHPRVCGAVMETVKQHGAGAGGTRNISGTSKFHVELEQALA
DLHGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMIQGIRNSRVPKYIFRH
NDVNHLRELLQRSDPSVPKIVAFETVHSMDGAVCPLEELCDVAHEFGAITFVDEVHAVGL
YGARGGGIGDRDGVMPKMDIISGTLGKAFGCVGGYIASTSLLIDTVRSYAAGFIFTTSLP
PMLLAGALESVRILKSSEGRALRRQHQRNVKLLRQMLMDAGLPVIHCPSHIIPVRVADAA
KNTEICDELMTRHNIYVQAINYPTVPRGEELLRIAPTPHHTPQMMNFFVEKLLVTWKRVG
LELKPHSSAECNFCRRPLHFEVMSEREKAYFSGMSKMVSAQA |
| Structure Information |
| PDB ID | NA |
| Quaternary structure | NA |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | |
| DisProt Annotation | |
| Predicted Disorder Regions | |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | enzyme, 5-aminolevulinic acid synthase 1, initiating enzyme for heme biosynthesis |
| References for function | Lee S, Lee S, Desnick R, Yasuda M, Lai EC. Noncanonical role of ALAS1 as a heme-independent inhibitor of small RNA-mediated silencing. Science. 2024 Dec 20;386(6728):1427-1434. doi: 10.1126/science.adp9388. Epub 2024 Dec 19. PMID: 39700288; PMCID: PMC11829814. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | repressor or miRNA accumulation |
| References for function | Lee S, Lee S, Desnick R, Yasuda M, Lai EC. Noncanonical role of ALAS1 as a heme-independent inhibitor of small RNA-mediated silencing. Science. 2024 Dec 20;386(6728):1427-1434. doi: 10.1126/science.adp9388. Epub 2024 Dec 19. PMID: 39700288; PMCID: PMC11829814. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | |
| Comments | |