| General Information |
| MoonProt ID | 1053 |
| First appeared in release | 4.0 |
| Name(s) | Drosophila melanogaster (Fruit fly) |
| UniProt ID | Q9VQZ6 |
| GO terms | "GO:0000049 tRNA binding
GO:0003723 RNA binding
GO:0003824 catalytic activity
GO:0016407 acetyltransferase activity
GO:0016740 transferase activity
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
GO:0061733 protein-lysine-acetyltransferase activity
GO:0106261 tRNA uridine(34) acetyltransferase activity
GO:0106261 tRNA uridine(34) acetyltransferase activity
GO:0002168 instar larval development
GO:0002926 tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006400 tRNA modification
GO:0007616 long-term memory
GO:0007626 locomotory behavior
GO:0008033 tRNA processing
GO:0030097 hemopoiesis
GO:0030431 sleep
GO:0048789 cytoskeletal matrix organization at active zone
GO:0050808 synapse organization
GO:0051124 synaptic assembly at neuromuscular junction
GO:0061867 establishment of mitotic spindle asymmetry
GO:2000289 regulation of photoreceptor cell axon guidance
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005634 nucleus
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005737 cytoplasm
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005829 cytosol
GO:0005874 microtubule
GO:0045202 synapse
GO:0033588 elongator holoenzyme complex
GO:0033588 elongator holoenzyme complex" |
| Organisms for which functions have been demonstrated | Drosophila melanogaster (Fruit fly) |
| Sequence length | 552.0 |
| FASTA sequence | ">sp|Q9VQZ6|ELP3_DROME Elongator complex protein 3 OS=Drosophila melanogaster OX=7227 GN=Elp3 PE=1 SV=1
MKAKKKLGVGLSRQERQVLVIGEIIQELLKAHEAKKDVNLNRMKSLVASKYGLDSSPRLV
DIIAAVPQDAKKILLPKLRAKPIRTASGIAVVAVMCKPHRCPHINMTGNICVYCPGGPDS
DFEYSTQSYTGYEPTSMRAIRSRYDPFLQTRHRVEQLKQLGHSVDKVEFIVMGGTFMCLP
EEYRDYFIRNLHDALSGHSSANVAEAVRYSEKSRTKCIGITIETRPDYCLKRHISDMLSY
GCTRLEIGVQSVYEDVARDTNRGHTVRAVCESFQLGKDAGYKIVTHMMPDLPNVDFERDI
EQFIEYFENPAFRSDGLKIYPTLVIRGTGLYELWKTGRYKSYPPSMLVDLVAKILALVPP
WTRVYRVQRDIPMPLVSSGVEHGNLRELALARMKDLGTTCRDVRTREVGIQEIHNKVRPY
EIELIRRDYVANGGWETFLSYEDPEQDILVGLLRLRKCSPDTFRPELKGECSIVRELHVY
GSVVPVNARDPTKFQHQGFGMLLMEEAERIAREEHGSTKLAVISGVGTRNYYRKMGYQLD
GPYMSKSIEENN" |
| Structure Information |
| PDB ID | NA |
| Quaternary structure | subunit of a multiprotein complex |
| SCOP | |
| CATH | |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | |
| Predicted Disorder Regions | |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | subunit of the Elongator tRNA-modifying complex that regulates protein translation |
| References for function | _ |
| E.C. number | NA |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | part of a complex that binds to microtubules to affect stability |
| References for function | Planelles-Herrero VJ, Genova M, Krüger LK, Bittleston A, McNally KE, Morgan TE, Degliesposti G, Magiera MM, Janke C, Derivery E. Elongator is a microtubule polymerase selective for polyglutamylated tubulin. EMBO J. 2025 Mar;44(5):1322-1353. doi: 10.1038/s44318-024-00358-0. Epub 2025 Jan 15. PMID: 39815006; PMCID: PMC11876699. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | |
| Comments | |