| General Information |
| MoonProt ID | 110 |
| First appeared in release | 1.0 |
| Name(s) | aconitase
aconitate hydratase
Gene Name: acn
|
| UniProt ID | A0A0H3L8I8 |
| GO terms | GO:0008152 metabolic process
GO:0003994 aconitate hydratase activity
GO:0016829 lyase activity
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding |
| Organisms for which functions have been demonstrated | Mycobacterium tuberculosis (mycobacterium, causes tuberculosis) |
| Sequence length | 938 aa |
| FASTA sequence | >tr|A0A0H3L8I8|A0A0H3L8I8_MYCTE Aconitate hydratase OS=Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman) GN=acn PE=4 SV=1
MNSFGAHDTLKVGEKSYQIYRLDAVPNTAKLPYSLKVLAENLLRNEDGSNITKDHIEAIANWDPKAEPSIEIQYTPARVVMQDFTGVPCIVDLATMREAIADLGGNPDKVNPLAPADLVIDHSVIADLFGRADAFERNVEIEYQRNGERYQFLRWGQGAFDDFKVVPPGTGIVHQVNIEYLASVVMTRDGVAYPDTCVGTDSHTTMVNGLGVLGWGVGGIEAEAAMLGQPVSMLIPRVVGFRLTGEIQPGVTATDVVLTVTEMLRQHGVVGKFVEFYGEGVAEVPLANRATLGNMSPEFGSTAAIFPIDEETIKYLRFTGRTPEQVALVEAYAKAQGMWHDPKHEPEFSEYLELNLSDVVPSIAGPKRPQDRIALAQAKSTFREQIYHYVGNGSPDSPHDPHSKLDEVVEETFPASDPGQLTFANDDVATDETVHSAAAHADGRVSNPVRVKSDELGEFVLDHGAVVIAAITSCTNTSNPEVMLGAALLARNAVEKGLTSKPWVKTTIAPGSQVVNDYYDRSGLWPYLEKLGFYLVGYGCTTCIGNSGPLPEEISKAVNDNDLSVTAVLSGNRNFEGRINPDVKMNYLASPPLVIAYALAGTMDFDFQTQPLGQDKDGKNVFLRDIWPSQQDVSDTIAAAINQEMFTRNYADVFKGDDRWRNLPTPSGNTFEWDPNSTYVRKPPYFEGMTAKPEPVGNISGARVLALLGDSVTTDHISPAGAIKPGTPAARYLDEHGVDRKDYNSFGSRRGNHEVMIRGTFANIRLRNQLLDDVSGGYTRDFTQPGGPQAFIYDAAQNYAAQHIPLVVFGGKEYGSGSSRDWAAKGTLLLGVRAVIAESFERIHRSNLIGMGVIPLQFPEGKSASSLGLDGTEVFDITGIDVLNDGKTPKTVCVQATKGDGATIEFDAVVRIDTPGEADYYRNGGILQYVLRNILKSG
|
| Structure Information |
| PDB ID | closest is human with 49% amino acid sequence identity |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-11, 389-454, 722-725, 935-938 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | aconitase, enzyme
catalyse the isomerization of citrate to iso-citrate in the citric acid cycle |
| References for function | |
| E.C. number | 4.2.1.3 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | iron-responsive protein
Binds to selected IREs (Iron-responsive elements)--sequences present within the UTR (untranslated regions) of M. tuberculosis mRNA
|
| References for function | S. Banerjee, A.K. Nandyala, P. Raviprasad, et al. (2007) Iron-Dependent RNA-Binding Activity of Mycobacterium tuberculosis Aconitase. J Bacteriol. 2007 Jun;189(11):4046-52. Epub 2007 Mar 23. PMID: 17384188 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |