General Information |
MoonProt ID | 114 |
First appeared in release | 1.0 |
Name(s) | Argininosuccinate lyase
ASAL
ASL
Arginosuccinase
Delta Crystallin II
Delta-2 Crystallin
Gene Name: ASL2
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UniProt ID | P24058 (ARLY2_ANAPL), Reviewed |
GO terms | GO: 0006526 arginine biosynthetic process
GO: 0008652 cellular amino acid biosynthetic process
GO: 0042450 arginine biosynthetic process via ornithine
GO: 0003824 catalytic activity
GO: 0004056 argininosuccinate lyase activity
GO: 0005212 structural constituent of eye lens
GO: 0016829 lyase activity |
Organisms for which functions have been demonstrated | Anas platyrhynchos (duck) |
Sequence length | 468 |
FASTA sequence | >sp|P24058|ARLY2_ANAPL Argininosuccinate lyase OS=Anas platyrhynchos GN=ASL2 PE=1 SV=4
MASEARGDKLWGGRFSGSTDPIMEKLNSSIAYDQRLSEVDIQGSMAYAKALEKAGILTKTELEKILSGLEKISEEWSKGVFVVKQSDEDIHTANERRLKELIGDIAGKLHTGRSRNDQVVTDLKLFMKNSLSIISTHLLQLIKTLVERAAIEIDVILPGYTHLQKAQPIRWSQFLLSHAVALTRDSERLGEVKKRINVLPLGSGALAGNPLDIDREMLRSELEFASISLNSMDAISERDFVVEFLSFATLLMIHLSKMAEDLIIYSTSEFGFLTLSDAFSTGSSLMPQKKNPDSLELIRSKAGRVFGRLASILMVLKGLPSTYNKDLQEDKEAVFDVVDTLTAVLQVATGVISTLQISKENMEKALTPEMLATDLALYLVRKGVPFRQAHTASGKAVHLAETKGITINKLSLEDLKSISPQFSSDVSQVFNFVNSVEQYTALAGTAKSSVTTQIEQLRELMKKQKEQA
|
Structure Information |
PDB ID | 1TJU 1TJV 1K7W 1AUW 1DCN |
Quaternary structure | |
SCOP | FYVE/PHD zinc finger |
CATH | 3.30.40.10 |
TM Helix Prediction | no TM helices |
DisProt Annotation | Not in DisProt |
Predicted Disorder Regions | 1-10, 458-468 |
Connections to Disease |
OMIM ID | |
Function 1 |
Function description | Argininosuccinate lyase, enzyme
Catalyzes the breakdown of argininosuccinate to produce arginine and fumarate. It is the fourth enzyme of the urea cycle. Argininosuccinase is involved in biosythesis of arginine in all species and production of urea in ureotelic organisms. 2-(N(omega)-L-arginino)succinate => fumarate + L-arginine
Amino-acid biosynthesis, arginine biosynthesis |
References for function | |
E.C. number | 4.3.2.1 |
Location of functional site(s) | |
Cellular location of function | cytoplasm |
Comments | |
Function 2 |
Function description | Delta-2 Crystallin in the lens of the eye - only in birds and reptiles |
References for function | Wistow G, Piatigorsky J. (1987) Recruitment of enzymes as lens structural proteins. Science. 1987 Jun 19;236(4808):1554-6.6. PMID: 3589669 |
E.C. number | N/A |
Location of functional site(s) | |
Cellular location of function | lens of eye |
Comments | |