| General Information |
| MoonProt ID | 12 |
| First appeared in release | 1.0 |
| Name(s) | 6-phosphogluconate dehydrogenase
Gene Name: gnd |
| UniProt ID | A0A0H2UNG6 |
| GO terms | GO:0006098 pentose-phosphate shunt
GO:0019521 D-gluconate metabolic process
GO:0055114 oxidation-reduction process
GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0050661 NADP binding
GO:0050662 coenzyme binding |
| Organisms for which functions have been demonstrated | Streptococcus pneumoniae (Gram positive bacterium) |
| Sequence length | 474 |
| FASTA sequence | >tr|A0A0H2UNG6|A0A0H2UNG6_STRPN 6-phosphogluconate dehydrogenase, decarboxylating OS=Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) GN=gnd PE=3 SV=1
MTKANFGVVGMAVMGRNLALNIESRGYTVAIYNRSKEKTEDVIACHPEKNFVPSYDVESFVNSIEKPRRIMLMVQAGPGTDATIQALLPHLDKGDILIDGGNTFYKDTIRRNEELANSGINFIGTGVSGGEKGALEGPSIMPGGQKEAYELVADVLEEISAKAPEDGKPCVTYIGPDGAGHYVKMVHNGIEYGDMQLIAESYDLMQHLLGLSAEDMAEIFTEWNKGELDSYLIEITADILSRKDDEGQDGPIVDYILDAAGNKGTGKWTSQSSLDLGVPLSLITESVFARYISTYKEERVHASKVLPKPAAFNFEGDKAELIEKIRQALYFSKIISYAQGFAQLRVASKENNWNLPFADIASIWRDGCIIRSRFLQKITDAYNRDADLANLLLDEYFLDVTAKYQQAVRDIVALAVQAGVPVPTFSAAITYFDSYRSADLPANLIQAQRDYFGAHTYQRKDKEGTFHYSWYDEK
|
| Structure Information |
| PDB ID | closest homologue with a structure in the PDB has 74% amino acid sequence identity |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-3, 305-313, 472-474 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | 6-phosphogluconate dehydrogenase, enzyme
6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH
Carbohydrate degradation, pentose phosphate pathway
|
| References for function | |
| E.C. number | 1.1.1.44 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | adhesin - not clear to which host protein |
| References for function | Daniely D, Portnoi M, Shagan M, Porgador A, Givon-Lavi N, Ling E, Dagan R, Mizrachi Nebenzahl Y (2006) Pneumococcal 6-phosphogluconate-dehydrogenase, a putative adhesin, induces protective immune response in mice. Clin Exp Immunol 144:254263. PMID: 16634799 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | inhibit bacterial adhesion to A459 type II lung carcinoma
cells, anti-r6PGD-antibodies inhibited 90% of S. pneumoniae adhesion to the cultured cells in a concentration-dependent manner - from Daniely D, Portnoi M, Shagan M, Porgador A, Givon-Lavi N, Ling E, Dagan R, Mizrachi Nebenzahl Y (2006) Pneumococcal 6-phosphogluconate-dehydrogenase, a putative adhesin, induces protective immune response in mice. Clin Exp Immunol 144:254263 |