| General Information |
| MoonProt ID | 14 |
| First appeared in release | 1.0 |
| Name(s) | alcohol acetaldehyde dehydrogenase (lmo1634)
ADH
ACDH
Listeria adhesion protein
LAP
Gene Name = aad
|
| UniProt ID | Q6Q3I2 (Q6Q3I2_LISMN), Unreviewed |
| GO terms | GO:0006066 alcohol metabolic process
GO:0008152 metabolic process
GO:0015976 carbon utilization
GO:0055114 oxidation-reduction process
GO:0004022 alcohol dehydrogenase (NAD) activity
GO:0008774 acetaldehyde dehydrogenase (acetylating) activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0046872 metal ion binding |
| Organisms for which functions have been demonstrated | Listeria monocytogenes (Gram positive bacterium) |
| Sequence length | 866 |
| FASTA sequence | >gi|45549367|gb|AAS67616.1| alcohol acetaldehyde dehydrogenase [Listeria monocytogenes]
MAIKENAAQEVLEVQKVIDRLADNGQKALKAFESYNQEQVDNIVHAMALAGLDQHMPLAKLAVEETGRGLYEDKCIKNIFATEYIWNNIKNNKTVGVINEDVQTGVIEIAEPVGVVAGVTPVTNPTSTTLFKAIIAIKTRNPIIFAFHPSAQRCSSAAAKVVYDAAIAAGAPEHCIQWVEKPSLEATKQLMNHDKVALVLATGGAGMVKSAYSTGKPALGVGPGNVPAYIDKTAKIKRSVNDIILSKSFDQGMICASEQAVIVDKEVAKEVKAEMEANKCYFVKGAEFKKLESYVINPEKGTLNPDVVGKSPAWIANQAGFKVPEDTKILVAEIKGVGDKYPLSHEKLSPVLAFIEAANQAEAFDRCEEMLVYGGLGHSAVIHSTDKEVQKAFGIRMKACRIIVNAPSAQGGIGDIYNGFIPSLTLGCGSYGKNSVSQNVSATNLLNVKRIADRRNNMQWFKLPPKIFFEKYSTQYLQKMEGVERVFIVTDPGMGSFKYVDVVIEHLKKRGNDVAYQVFADVEPDPSDVTVYKGAELMKDFKPDTIIALGGGSAMDAAKGMWLFYEHPEASFFGLKQKFLDIRKRTFKYPKLGGKAKFVAIPTTSGTGSEVTPFAVITDKENNIKYPLADYELTPDVAIVDAQYVTTVPAHITADTGMDVLTHAIESYVSVMASDYTRGLSIRAIELVFENLRESVLTGDPDAREKMHNASALAGMAFANAFLGINHSLAHKIGPEFHIPHGRANAILMPHVIRYNALKPKKHALFPRYESFRADEDYARISRIIGFPAATTEEGVKSLVDEIIKLGKDVGIDMSLKGQNVAKKDLDAVVDTLADRAFMDQCTTANPKQPLVSELKEIYLEAYKGV |
| Structure Information |
| PDB ID | Closest homologue is 6AHC_A with 48. 62% amino acid seuqnece identity |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1--12, 866 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | An enzyme: The N-terminus contains acetaldehyde dehydrogenase (ALDH) and the Cterminus an alcohol dehydrogenase (ADH)
|
| References for function | Jagadeesan B, Koo OK, Kim KP, Burkholder KM, Mishra KK, Aroonnual A, Bhunia AK. LAP, an alcohol acetaldehyde dehydrogenase enzyme in Listeria, promotes bacterial adhesion to enterocyte-like Caco-2 cells only in pathogenic species. Microbiology. 2010 Sep;156:2782-2795 PMID: 20507888 |
| E.C. number | EC=1.1.1.1
EC=1.2.1.10 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | Adhesin, binds Hsp60 on surface of host cells |
| References for function | Jagadeesan B, Koo OK, Kim KP, Burkholder KM, Mishra KK, Aroonnual A, Bhunia AK. LAP, an alcohol acetaldehyde dehydrogenase enzyme in Listeria, promotes bacterial adhesion to enterocyte-like Caco-2 cells only in pathogenic species. Microbiology. 2010 Sep;156:2782-2795 PMID: 20507888 |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | binds Hsp60 on surface of host cells
reference: Wampler JL, Kim KP, Jaradat Z, Bhunia AK.Heat shock protein 60 acts as a receptor for the Listeria adhesion protein in Caco-2 cells. Infect Immun. 2004 Feb;72(2):931-6. PMID: 14742538 |