| General Information |
| MoonProt ID | 143 |
| First appeared in release | 1.0 |
| Name(s) | citrate synthase |
| UniProt ID | I7MG78 |
| GO terms | GO:0006099 tricarboxylic acid cycle
GO:0044262 cellular carbohydrate metabolic process
GO:0016740 transferase activity
GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer |
| Organisms for which functions have been demonstrated | Tetrahymena thermophila |
| Sequence length | 474 |
| FASTA sequence | >tr|I7MG78|I7MG78_TETTS Citrate synthase OS=Tetrahymena thermophila (strain SB210) GN=TTHERM_00318570 PE=3 SV=1
MRKQIINCKRLYHQNQYFFNPKADLKTVLREQIPIKIQGFNEMKKKYGDRVMGEITVNQALGGMRGIRALFYDQSTVDPIDGVMFRGYSIPELHELLPKLRKPSAEDFQSDQQPLPEGLFFLLLTGELPSYHQVELIRHEWDVRGKVSDELINFINRLDNKMHPMTMLSLAILYEQKTSKFAQLYNESKLNKSNYWEYTYEDSVDLIAKLPRIAATIYRKKFKDGKPIAHKDGLDWSAQLAHMMGFEGQETLNELLRAFLTIHADHEGGEVSTHASHLVGSALGDPYLCMTTAYTGLAGPLHGLANQEVLKWILNFVEVHGYDVTNRQIEDYVNTTVLSGRLVPGYGHAVLRRPDPRFLHLYDFGNKYLRDNEMIRLLHQMTDVIPRRLRTFKNISSPYPNVDCHSGALLYQLGIQEYQFYTVLFAISRSIGCLTNLVWCRAFGLPIERPESADLAYYNNLFQNKIPKQEKDDQ |
| Structure Information |
| PDB ID | Closest homologue in PDB is from Sus scrofa with 45.12% amino acid sequence identity; 90% query cover |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1 to 16, 104-110, 187-190, 463-474 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | citrate synthase, enzyme
acetyl-CoA + oxaloacetate + H2O => citrate + CoA-SH
Citric acid cycle |
| References for function | |
| E.C. number | 2.3.3.1 |
| Location of functional site(s) | |
| Cellular location of function | |
| Comments | |
| Function 2 |
| Function description | 14-nm cytoskeletal protein |
| References for function | Numata O. Multifunctional proteins in Tetrahymena: 14-nm filament protein/citrate synthase and translation elongation factor-1 alpha. Int Rev Cytol. 1996 0. PMID: 8575889 |
| E.C. number | N.A |
| Location of functional site(s) | |
| Cellular location of function | cytosol, cytoskeleton |
| Comments | |