| General Information |
| MoonProt ID | 144 |
| First appeared in release | 1.0 |
| Name(s) | galactokinase
Galactose kinase
Gene Name: GAL1 |
| UniProt ID | P09608 |
| GO terms | GO:0005975 carbohydrate metabolic process
GO:0006012 galactose metabolic process
GO:0008152 metabolic process
GO:0016310 phosphorylation
GO:0046835 carbohydrate phosphorylation
GO:0000166 nucleotide binding
GO:0004335 galactokinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0005737 cytoplasm |
| Organisms for which functions have been demonstrated | Kluyveromyces lactis |
| Sequence length | 503 |
| FASTA sequence | >sp|P09608|GAL1_KLULA Galactokinase OS=Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) GN=GAL1 PE=2 SV=2
MSVPIVPTDFAHAPKLEQLKNEFVECYDTDDSRKFFITRSPGRVNLIGEHIDYCQFSVLPMAIENDLMLACRLTSESENPSITLTNHDSNFAQRKFDLPLDGSLIEIDPSVSDWSNYFKCGLLVAQQFLQEKYNFKGPVHGMEIYVKGDIPSGGGLSSSAAFICAVSLAIIYSNVPAGTPILKDELTKTTAVAEHHVGVNNGGMDQAASICGIEGHALYVEFKPELKATPFKFPEDLPISFLIANTLVVSNKAETGPVNYNLRVVEVTVAANVLAQKFGVTLQTEGNLGKGTLRNFMDSYYTKYDKSCRKPWDGEIQTGIERLNKMLQLVEETLDPNGYTLDHAVELCGCESISQFTELYLTNFPVRFQRLKLFQRAKHVYSEALRVLKALQLFQKGESNFFEEFGALMNESQESCDKLYECSCPETDSICEIALKNGSFGSRLTGAGWGGCTVHLCSTDTVDSVKSALTEQYYNLRFPELTAEELEDAIIISKPSLGSVLYE |
| Structure Information |
| PDB ID | Closest homologue in PDB is from S. cerevisiae with 59.53% amino acid sequence; 97% query cover |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1 to 12, 309-314, 502-503 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | galactokinase
ATP + galactose => ADP + galactose 1-phosphate.
Carbohydrate metabolism; galactose metabolism |
| References for function | |
| E.C. number | 2.7.1.6 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | transcriptional activator of GAL genes
|
| References for function | Galactokinase encoded by GAL1 is a bifunctional protein required for induction of the GAL genes in Kluyveromyces lactis and is able to suppress the gal3 phenotype in Saccharomyces cerevisiae. Meyer J., Walker-Jonah A., Hollenberg C.P. Mol. Cell. Biol. 11:5454-5461(1991). PMID: 1922058 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | nucleus |
| Comments | |