| General Information |
| MoonProt ID | 150 |
| First appeared in release | 1.0 |
| Name(s) | aconitase
iron-responsive element binding protein
Cytoplasmic aconitate hydratase
Citrate hydro-lyase
Iron-responsive element-binding protein 1
IRE-BP 1
Gene Name:ACO1 |
| UniProt ID | Q0VCU1 (ACOC_BOVIN) Reviewed |
| GO terms | GO:0006099 tricarboxylic acid cycle
GO:0006101 citrate metabolic process
GO:0008152 metabolic process
GO:0010040 response to iron(II) ion
GO:0003723 RNA binding
GO:0003994 aconitate hydratase activity
GO:0016829 lyase activity
GO:0030350 iron-responsive element binding
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
GO:0005737 cytoplasm |
| Organisms for which functions have been demonstrated | Bos taurus (bovine, a mammal) |
| Sequence length | 889 |
| FASTA sequence | >sp|Q0VCU1|ACOC_BOVIN Cytoplasmic aconitate hydratase OS=Bos taurus GN=ACO1 PE=2 SV=1
MSNPFAHLVEPLDPAQPGKKFFNLNKLEDSRYGSLPFSIRVLLEAAIRNCDQFLVKKNDVENILNWKVMQHKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGNPEKINPICPADLVIDHSIQVDFNRRADSLKKNQDLEFERNKERFEFLKWGSQAFHNMRIIPPGSGIIHQVNLEYLARVVFDQDGYYYPDSLVGTDSHTTMIDGLGVLGWGVGGIEAEAVMLGQPISMVLPQVIGYRLVGNPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMCPEYGATAAFFPVDEVSIKYLVQTGRDKEKVKHIKQYLQAVGMFRDFSDSSQDPDFAQVVELDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGFQVAPDHHNDHKTFIYNNSKFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVDAGLSVKPYIKTSLSPGSGVVTYYLRESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEAVVEAIVQGDLVAVGVLSGNRNFEGRVHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGVNAKGQQVFLKDIWPTRDEIQAVERQYVIPGMFKEVYQKIETVNESWNALAAPSDKLYCWNPKSTYIKSPPFFEDLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGLTPREFNSYGSRRGNDAIMARGTFANIRLLNKFLNKQAPQTIHLPSGEILDVFDAAERYQQAGLPLIVLAGKEYGSGSSRDWAAKGPFLLGIRAVLAESYERIHRSNLVGMGVIPLEYLPGENADTLGLTGRERYTISIPETLKPRMKVQIKLDTGKTFQAVMRFDTDVELTYFHNGGILNYMIRKMTK
|
| Structure Information |
| PDB ID | 2B3X 2B3Y |
| Quaternary structure | |
| SCOP | The "swivelling" beta/beta/alpha domain, Aconitase iron-sulfur domain |
| CATH | 3.30.499.10, 3.40.1060.10, 6.10.190.10, 3.20.19.10 |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1 to 15, 396-413, 685-687, 888-889 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | aconitase, enzyme
4Fe-4S cluster in active site when cellular iron levels are high Citrate <=> isocitrate
Citric acid cycle |
| References for function | |
| E.C. number | 4.2.1.3 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | iron responsive element binding protein
when cellular iron concentrations are low, loses 4Fe-4S cluster and binds to iron-responsive elements (IRES) in mRNA that encodes proteins that are involved in iron uptake and use |
| References for function | Kennedy MC, MendeMueller L, Blondin GA, Beinert H. Purification and characterization of cytosolic aconitase from beef liver and its relationship to the iron-responsive element binding protein. Proc Natl Acad Sci U S A. 1992 Dec 15. PMID: 1334546 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |