| General Information |
| MoonProt ID | 155 |
| First appeared in release | 1.0 |
| Name(s) | AtlC
Fibronectin binding autolysin
Gene Name:atlC |
| UniProt ID | Q9AIS0 (Q9AIS0_9STAP), Unreviewed |
| GO terms | GO:0009253 peptidoglycan catabolic process
GO:0044036 cell wall macromolecule metabolic process
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity
GO:0016787 hydrolase activity |
| Organisms for which functions have been demonstrated | Staphylococcus caprae (Gram positive bacterium) |
| Sequence length | 1395 |
| FASTA sequence | >tr|Q9AIS0|Q9AIS0_9STAP Fibronectin binding autolysin OS=Staphylococcus caprae GN=atlC PE=4 SV=1
MTKKFNYKLPSMVALTLFGTAFTAHHAHAAEETQDQTKNSNVLDDQATLKQAEQAKNEVTQSAQNVSGTQTYQDPTKVQSKQDTTSNNYDASLDELNDSSSKASQQEQSNNSNQPTDSKETNTSSVNTYQDSTKDIKNNEISKDAVTSEDNETSKVDNTNKEVSETEQQESTVENVNKDENSNNNIQASSNQTNNLNDQEKQEATSNQASNNKTSQQATTDSTEKSNNKVSQTNSSGYNFDDDEDDVDTTNAQSKNTKADQPQVASLSAQNNVNTKSESNPTIKNSTNSTNTSKSATQNTKVSNTQANNTTTESNNKVSTFSSVAKPRMMYAVNKKTTSSLPKYTPQVKSSINDYIRKKNYKAPQIEENYTSYFPKYGYRNGVGRPEGIVVHDTANDNSTIDGEINYMKNNYQSAFVHAFVDGNRIVETAPTDYLSWGAGPQGNERFINVEIVHTHDYDSFARSMNNYADYAATQLQYYGLKPDSAENDGQGTVWTHYAISRYLGGTDHTDPHQYFRSHNYSYAELYDLIYEKYLIKTGQVAPWGTSSTSPSKPSKPSDSSNNNKLTVSANSGVAQIKPSNSGLYTTVYDEKGHSTDQAQKTLSVTKSATLGNNKFYLVEDYNTGKKYGWVKQGDVVYNTAKSPVKVNQTYNVKAGSTLYTVPWGTPSQVASKVSGSGNQTFKATKQQQIDKAIYLYGTVNGKSGWISKYYLTTPSSSNTKPSKPSTDNSSSNNKLTVSANSGVAQIKAKNNGVYTTVYDKKGKTTDQVQRTLSVTKSATLGNDKFYLVEDYNTGKKYGWVKQDDVVYNTAKSPVKVNQNYSIKPGVKLYTVPWGTYNQVASTVSGSGNQTFKATKQQQIDKATYLYGTVNGKSGWVSKYYLTTPTQSKVAVSKPKTSTKAVSTNSKATTADRAAITQTSAKASNTNSTQTINKIAQVKANNSGIRASVFDKKAKSGAKYGNRTYIITKQRTEGNNTYVLLQDSTRNTPLGWVNVKDVTSQNIGNQTKATGQYKVSQTNNGLYSIAWGTKNQQLLPSNTIASKTFNASKSLYVGKDLYLYGTVNNRTGWIAAKDLIQSNKDVQARPYNYTFVISNSNSYYYEDLGKNARYSLKPYYDKTFVVSKQKNINGVTWYYGKLTNGKYVWIKSTDVAKESVKYVNTGYTLAHAAEIQNDLYDTPQIQKVPGQWTNANYNEIKDAMDPNKLTKDSGARYQFLRLDQPQSLSVAALNELLKGQGVLEGQGAAFSEAAKKYGINEIYLVAHALVETGNGTSQLAKGGDIVNGKFSDKTKTKYHNVFGIGAYDSSPLIEGIKYAKNAGWDSVSKAIIGGAKFIGQSYIKAGQNTLYKMRWNPSNPGTHQYATDIHWATVNAQTIKGFYDKIGEVGKYYEIPKYK
|
| Structure Information |
| PDB ID | Closest homologue in PDB is from Staphylococcus epidermidis with 87.79% amino acid sequence identity; 15% query cover |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices
MTKKFNYKLPSMVALTLFGTAFTAHHAHAAEETQDQTKNSNVLDDQATLKQAEQAKNEVTQSAQNVSGTQTYQDPTKVQSKQDTTSNNYDASLDELNDSSSKASQQEQSNNSNQPTDSKETNTSSVNTYQDSTKDIKNNEISKDAVTSEDNETSKVDNTNKEVSETEQQESTVENVNKDENSNNNIQASSNQTNNLNDQEKQEATSNQASNNKTSQQATTDSTEKSNNKVSQTNSSGYNFDDDEDDVDTTNAQSKNTKADQPQVASLSAQNNVNTKSESNPTIKNSTNSTNTSKSATQNTKVSNTQANNTTTESNNKVSTFSSVAKPRMMYAVNKKTTSSLPKYTPQVKSSINDYIRKKNYKAPQIEENYTSYFPKYGYRNGVGRPEGIVVHDTANDNSTIDGEINYMKNNYQSAFVHAFVDGNRIVETAPTDYLSWGAGPQGNERFINVEIVHTHDYDSFARSMNNYADYAATQLQYYGLKPDSAENDGQGTVWTHYAISRYLGGTDHTDPHQYFRSHNYSYAELYDLIYEKYLIKTGQVAPWGTSSTSPSKPSKPSDSSNNNKLTVSANSGVAQIKPSNSGLYTTVYDEKGHSTDQAQKTLSVTKSATLGNNKFYLVEDYNTGKKYGWVKQGDVVYNTAKSPVKVNQTYNVKAGSTLYTVPWGTPSQVASKVSGSGNQTFKATKQQQIDKAIYLYGTVNGKSGWISKYYLTTPSSSNTKPSKPSTDNSSSNNKLTVSANSGVAQIKAKNNGVYTTVYDKKGKTTDQVQRTLSVTKSATLGNDKFYLVEDYNTGKKYGWVKQDDVVYNTAKSPVKVNQNYSIKPGVKLYTVPWGTYNQVASTVSGSGNQTFKATKQQQIDKATYLYGTVNGKSGWVSKYYLTTPTQSKVAVSKPKTSTKAVSTNSKATTADRAAITQTSAKASNTNSTQTINKIAQVKANNSGIRASVFDKKAKSGAKYGNRTYIITKQRTEGNNTYVLLQDSTRNTPLGWVNVKDVTSQNIGNQTKATGQYKVSQTNNGLYSIAWGTKNQQLLPSNTIASKTFNASKSLYVGKDLYLYGTVNNRTGWIAAKDLIQSNKDVQARPYNYTFVISNSNSYYYEDLGKNARYSLKPYYDKTFVVSKQKNINGVTWYYGKLTNGKYVWIKSTDVAKESVKYVNTGYTLAHAAEIQNDLYDTPQIQKVPGQWTNANYNEIKDAMDPNKLTKDSGARYQFLRLDQPQSLSVAALNELLKGQGVLEGQGAAFSEAAKKYGINEIYLVAHALVETGNGTSQLAKGGDIVNGKFSDKTKTKYHNVFGIGAYDSSPLIEGIKYAKNAGWDSVSKAIIGGAKFIGQSYIKAGQNTLYKMRWNPSNPGTHQYATDIHWATVNAQTIKGFYDKIGEVGKYYEIPKYK
>tr|Q9AIS0|Q9AIS0_9STAP Fibronectin binding autolysin OS=Staphylococcus caprae GN=atlC PE=4 SV=1
MTKKFNYKLPSMVALTLFGTAFTAHHAHAAEETQDQTKNSNVLDDQATLKQAEQAKNEVTQSAQNVSGTQTYQDPTKVQSKQDTTSNNYDASLDELNDSSSKASQQEQSNNSNQPTDSKETNTSSVNTYQDSTKDIKNNEISKDAVTSEDNETSKVDNTNKEVSETEQQESTVENVNKDENSNNNIQASSNQTNNLNDQEKQEATSNQASNNKTSQQATTDSTEKSNNKVSQTNSSGYNFDDDEDDVDTTNAQSKNTKADQPQVASLSAQNNVNTKSESNPTIKNSTNSTNTSKSATQNTKVSNTQANNTTTESNNKVSTFSSVAKPRMMYAVNKKTTSSLPKYTPQVKSSINDYIRKKNYKAPQIEENYTSYFPKYGYRNGVGRPEGIVVHDTANDNSTIDGEINYMKNNYQSAFVHAFVDGNRIVETAPTDYLSWGAGPQGNERFINVEIVHTHDYDSFARSMNNYADYAATQLQYYGLKPDSAENDGQGTVWTHYAISRYLGGTDHTDPHQYFRSHNYSYAELYDLIYEKYLIKTGQVAPWGTSSTSPSKPSKPSDSSNNNKLTVSANSGVAQIKPSNSGLYTTVYDEKGHSTDQAQKTLSVTKSATLGNNKFYLVEDYNTGKKYGWVKQGDVVYNTAKSPVKVNQTYNVKAGSTLYTVPWGTPSQVASKVSGSGNQTFKATKQQQIDKAIYLYGTVNGKSGWISKYYLTTPSSSNTKPSKPSTDNSSSNNKLTVSANSGVAQIKAKNNGVYTTVYDKKGKTTDQVQRTLSVTKSATLGNDKFYLVEDYNTGKKYGWVKQDDVVYNTAKSPVKVNQNYSIKPGVKLYTVPWGTYNQVASTVSGSGNQTFKATKQQQIDKATYLYGTVNGKSGWVSKYYLTTPTQSKVAVSKPKTSTKAVSTNSKATTADRAAITQTSAKASNTNSTQTINKIAQVKANNSGIRASVFDKKAKSGAKYGNRTYIITKQRTEGNNTYVLLQDSTRNTPLGWVNVKDVTSQNIGNQTKATGQYKVSQTNNGLYSIAWGTKNQQLLPSNTIASKTFNASKSLYVGKDLYLYGTVNNRTGWIAAKDLIQSNKDVQARPYNYTFVISNSNSYYYEDLGKNARYSLKPYYDKTFVVSKQKNINGVTWYYGKLTNGKYVWIKSTDVAKESVKYVNTGYTLAHAAEIQNDLYDTPQIQKVPGQWTNANYNEIKDAMDPNKLTKDSGARYQFLRLDQPQSLSVAALNELLKGQGVLEGQGAAFSEAAKKYGINEIYLVAHALVETGNGTSQLAKGGDIVNGKFSDKTKTKYHNVFGIGAYDSSPLIEGIKYAKNAGWDSVSKAIIGGAKFIGQSYIKAGQNTLYKMRWNPSNPGTHQYATDIHWATVNAQTIKGFYDKIGEVGKYYEIPKYK
no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1 to 10, 27-310, 510-535, 562, 568, 645, 684-693, 852-867, 956, 1212-1221, 1334-1335 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | autolysin, enzyme
N-acetylmuramoyl-L-alanine amidase
hydrolyze peptidoglycan in cell wall |
| References for function | |
| E.C. number | 3.5.1.28 |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |
| Function 2 |
| Function description | fibronectin binding |
| References for function | Allignet J, England P, Old I, El Solh. Several regions of the repeat domain of the Staphylococcus caprae autolysin, AtlC, are involved in fibronectin binding. FEMS Microbiol Lett. 2002 Aug 6. PMID: 12167537 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |