Protein Information

General Information
MoonProt ID159
First appeared in release1.0
Name(s)thioredoxin Gene Name:trxA
UniProt IDD3QX74 (D3QX74_ECOCB), Unreviewed
GO termsGO:0006662 glycerol ether metabolic process GO:0045454 cell redox homeostasis GO:0055114 oxidation-reduction process GO:0015035 protein disulfide oxidoreductase activity
Organisms for which functions have been demonstratedEscherichia coli (Gram negative bacterium)
Sequence length127
FASTA sequence>tr|D3QX74|D3QX74_ECOCB Thioredoxin OS=Escherichia coli O55:H7 (strain CB9615 / EPEC) GN=trxA PE=3 SV=1 MLHQQRNQHARLIPVELYMSDKIIHLTDDSFDTDVLKADGAILVDFWAEWCGPCKMIAPILDEIADEYQGKLTVAKLNIDQNPGTAPKYGIRGIPTLLLFKNGEVAATKVGALSKGQLKEFLDANLA
Structure Information
PDB ID3DXB, 2TRX, 1T7P, 1SKR, 1SKS, 1SKW, 1SL0, 1SL1, 1SL2, 1TK0, 1TK5, 1TK8, 1TKD, 1T8E, 1X9M, 1X9S, 1X9W, 2BTO, 1ZYQ, 2AJQ, 2H6X, 1ZZY, 3DYR, 2H76, 2H71, 2H75, 2H70, 2H74, 2H73, 2TIR, 2H6Z, 2H72, 2H6Y, 2FCH
Quaternary structure
SCOPNA
CATHNA
TM Helix Predictionno TM helices
DisProt AnnotationNot in DisProt
Predicted Disorder Regions1 to 12, 125-127
Connections to Disease
OMIM ID
Function 1
Function descriptionthioredoxin antioxidant aids the reduction of other proteins by cysteine thiol-disulfide exchange
References for function
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionSubunit of T7 DNA polymerase ****maybe not strictly considered moonlighting because adopted by a phage to be part of a protein complex*****
References for functionMark DF, Richardson CC. Escherichia coli thioredoxin: a subunit of bacteriophage T7 DNA polymerase. Proc Natl Acad Sci U S A. 1976 Mar. PMID: 768986
E.C. numberN/A
Location of functional site(s)
Cellular location of functionbinding to DNA
Comments