General Information |
MoonProt ID | 172 |
First appeared in release | 1.0 |
Name(s) | glutamyl-prolyl tRNA synthetase
Bifunctional glutamate/proline--tRNA ligase
Bifunctional aminoacyl-tRNA synthetase
Cell proliferation-inducing gene 32 protein
Glutamatyl-prolyl-tRNA synthetase
Glutamate--tRNA ligase
Glutamyl-tRNA synthetase
GluRS
Proline--tRNA ligase
Prolyl-tRNA synthetase
Gene Name: EPRS |
UniProt ID | P07814 (SYEP_HUMAN), Reviewed |
GO terms | GO:0006412 translation
GO:0006417 regulation of translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006424 glutamyl-tRNA aminoacylation
GO:0006433 prolyl-tRNA aminoacylation
GO:0006461 protein complex assembly
GO:0008152 metabolic process
GO:0010467 gene expression
GO:0017148 negative regulation of translation
GO:0043039 tRNA aminoacylation
GO:0071346 cellular response to interferon-gamma
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003824 catalytic activity
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004818 glutamate-tRNA ligase activity
GO:0004827 proline-tRNA ligase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds
GO:0035613 RNA stem-loop binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0030529 ribonucleoprotein complex
GO:0097452 GAIT complex |
Organisms for which functions have been demonstrated | Homo sapiens (human, a mammal) |
Sequence length | 1512 |
FASTA sequence | >sp|P07814|SYEP_HUMAN Bifunctional glutamate/proline--tRNA ligase OS=Homo sapiens GN=EPRS PE=1 SV=5
MATLSLTVNSGDPPLGALLAVEHVKDDVSISVEEGKENILHVSENVIFTDVNSILRYLARVATTAGLYGSNLMEHTEIDHWLEFSATKLSSCDSFTSTINELNHCLSLRTYLVGNSLSLADLCVWATLKGNAAWQEQLKQKKAPVHVKRWFGFLEAQQAFQSVGTKWDVSTTKARVAPEKKQDVGKFVELPGAEMGKVTVRFPPEASGYLHIGHAKAALLNQHYQVNFKGKLIMRFDDTNPEKEKEDFEKVILEDVAMLHIKPDQFTYTSDHFETIMKYAEKLIQEGKAYVDDTPAEQMKAEREQRIDSKHRKNPIEKNLQMWEEMKKGSQFGQSCCLRAKIDMSSNNGCMRDPTLYRCKIQPHPRTGNKYNVYPTYDFACPIVDSIEGVTHALRTTEYHDRDEQFYWIIEALGIRKPYIWEYSRLNLNNTVLSKRKLTWFVNEGLVDGWDDPRFPTVRGVLRRGMTVEGLKQFIAAQGSSRSVVNMEWDKIWAFNKKVIDPVAPRYVALLKKEVIPVNVPEAQEEMKEVAKHPKNPEVGLKPVWYSPKVFIEGADAETFSEGEMVTFINWGNLNITKIHKNADGKIISLDAKLNLENKDYKKTTKVTWLAETTHALPIPVICVTYEHLITKPVLGKDEDFKQYVNKNSKHEELMLGDPCLKDLKKGDIIQLQRRGFFICDQPYEPVSPYSCKEAPCVLIYIPDGHTKEMPTSGSKEKTKVEATKNETSAPFKERPTPSLNNNCTTSEDSLVLYNRVAVQGDVVRELKAKKAPKEDVDAAVKQLLSLKAEYKEKTGQEYKPGNPPAEIGQNISSNSSASILESKSLYDEVAAQGEVVRKLKAEKSPKAKINEAVECLLSLKAQYKEKTGKEYIPGQPPLSQSSDSSPTRNSEPAGLETPEAKVLFDKVASQGEVVRKLKTEKAPKDQVDIAVQELLQLKAQYKSLIGVEYKPVSATGAEDKDKKKKEKENKSEKQNKPQKQNDGQRKDPSKNQGGGLSSSGAGEGQGPKKQTRLGLEAKKEENLADWYSQVITKSEMIEYHDISGCYILRPWAYAIWEAIKDFFDAEIKKLGVENCYFPMFVSQSALEKEKTHVADFAPEVAWVTRSGKTELAEPIAIRPTSETVMYPAYAKWVQSHRDLPIKLNQWCNVVRWEFKHPQPFLRTREFLWQEGHSAFATMEEAAEEVLQILDLYAQVYEELLAIPVVKGRKTEKEKFAGGDYTTTIEAFISASGRAIQGGTSHHLGQNFSKMFEIVFEDPKIPGEKQFAYQNSWGLTTRTIGVMTMVHGDNMGLVLPPRVACVQVVIIPCGITNALSEEDKEALIAKCNDYRRRLLSVNIRVRADLRDNYSPGWKFNHWELKGVPIRLEVGPRDMKSCQFVAVRRDTGEKLTVAENEAETKLQAILEDIQVTLFTRASEDLKTHMVVANTMEDFQKILDSGKIVQIPFCGEIDCEDWIKKTTARDQDLEPGAPSMGAKSLCIPFKPLCELQPGAKCVCGKNPAKYYTLFGRSY |
Structure Information |
PDB ID | 5VAD_A |
Quaternary structure | |
SCOP | NA |
CATH | 3.30.930.10, 3.40.50.800, 3.30.110.30 |
TM Helix Prediction | no TM helices |
DisProt Annotation | Not in DisProt |
Predicted Disorder Regions | 1 to 11, 166-196, 237-242, 300-312, 708-749, 767-775, 795-823, 841-847, 872-900, 918-926, 949-1015, 1467-1471 |
Connections to Disease |
OMIM ID | |
Function 1 |
Function description | glutamyl-prolyl tRNA synthetase, enzyme
an aminoacyl-tRNA synthetase
catalyze the attachment of amino acids to cognate tRNAs
ATP + L-glutamate + tRNA(Glu) => AMP + diphosphate + L-glutamyl-tRNA(Glu)
ATP + L-proline + tRNA(Pro) => AMP + diphosphate + L-prolyl-tRNA(Pro) |
References for function | |
E.C. number | 6.1.1.17 and 6.1.1.15 |
Location of functional site(s) | |
Cellular location of function | cytoplasm |
Comments | |
Function 2 |
Function description | translation inhibition
part of GAIT complex: interferon (IFN)-gamma-activated inhibitor of translation
silences ceruloplasmin mRNA translation
|
References for function | Sampath P, Mazumder B, Seshadri V, Gerber CA, Chavatte L, Kinter M, Ting SM, Dignam JD, Kim S, Driscoll DM, Fox PL. Noncanonical function of glutamyl-prolyl-tRNA synthetase: gene-specific silencing of translation. Cell. 2004 Oct 15. PMID: 15479637 |
E.C. number | N/A |
Location of functional site(s) | |
Cellular location of function | cytoplasm |
Comments | |