Protein Information

General Information
MoonProt ID182
First appeared in release1.0
Name(s)60S ribosomal protein L12 Gene Name:rpl-12
UniProt IDP61866 (RL12_CAEEL), Reviewed
GO termsGO:0006412 translation GO:0003723 RNA binding GO:0003735 structural constituent of ribosome GO:0005840 ribosome GO:0030529 ribonucleoprotein complex
Organisms for which functions have been demonstratedCaenorhabditis elegans (nematode, worm)
Sequence length165
FASTA sequence>sp|P61866|RL12_CAEEL 60S ribosomal protein L12 OS=Caenorhabditis elegans GN=rpl-12 PE=3 SV=1 MPPKFDPTEIKIVYLRCVGGEVGATSALAPKVGPLGLSPKKIGEDIAKATQDWKGLKVTCKLTIQNRVAKIDVVPSAASLIVKELKEPPRDRKKVKNVKHNGDLTVDTIIKIARIMRPRSMAKKLEGTVKEILGTAQSVGCTIDGQHPHDIIESIANGEIEIPAQ
Structure Information
PDB IDClosest homologue in PDB is from Drosophila melanogaster with 74.55% amino acid sequence identity
Quaternary structure
SCOPNA
CATHNA
TM Helix Predictionno TM helices
DisProt AnnotationNot in DisProt
Predicted Disorder Regions1 to 4, 6, 86-98, 163-165
Connections to Disease
OMIM ID
Function 1
Function descriptionribosomal protein Binds RNA directly (26S rRNA)
References for function
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm, part of ribosome
Comments
Function 2
Function descriptioninhibits splicing of its own RNA
References for functionMitrovich QM, Anderson P. Unproductively spliced ribosomal protein mRNAs are natural targets of mRNA surveillance in C. elegans. Genes Dev. 2000 Sep 1. PMID: 10970881
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm
Comments