| General Information |
| MoonProt ID | 188 |
| First appeared in release | 1.0 |
| Name(s) | 60S ribosomal protein L26
Gene Name:RPL26 |
| UniProt ID | P61254 (RL26_HUMAN), Reviewed |
| GO terms | GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006364 rRNA processing
GO:0006412 translation
GO:0006413 translational initiation
GO:0006414 translational elongation
GO:0006415 translational termination
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0010467 gene expression
GO:0016032 viral process
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0019058 viral life cycle
GO:0019083 viral transcription
GO:0042273 ribosomal large subunit biogenesis
GO:0044267 cellular protein metabolic process
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0044822 poly(A) RNA binding
GO:0005622 intracellular
GO:0005829 cytosol
GO:0005840 ribosome
GO:0015934 large ribosomal subunit
GO:0022625 cytosolic large ribosomal subunit
GO:0030529 ribonucleoprotein complex
GO:0070062 extracellular vesicular exosome |
| Organisms for which functions have been demonstrated | Homo sapiens (human, a mammal) |
| Sequence length | 145 |
| FASTA sequence | >sp|P61254|RL26_HUMAN 60S ribosomal protein L26 OS=Homo sapiens GN=RPL26 PE=1 SV=1
MKFNPFVTSDRSKNRKRHFNAPSHIRRKIMSSPLSKELRQKYNVRSMPIRKDDEVQVVRGHYKGQQIGKVVQVYRKKYVIYIERVQREKANGTTVHVGIHPSKVVITRLKLDKDRKKILERKAKSRQVGKEKGKYKEETIEKMQE
|
| Structure Information |
| PDB ID | 2ZKR, 3J3B |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1 to 5, 7-13, 123-145 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | ribosomal protein, part of 60S subunit |
| References for function | |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm, part of ribosome |
| Comments | |
| Function 2 |
| Function description | regulates (increases) translation of p53 tumor suppressor protein after DNA damage, leading to cell cycle arrest and apoptosis
binds 5' UTR of p53 mRNA |
| References for function | Takagi M, Absalon MJ, McLure KG, Kastan MB. Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. Cell. 2005 Oct 7. PMID: 16213212 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |