| General Information |
| MoonProt ID | 19 |
| First appeared in release | 1.0 |
| Name(s) | DnaK
Chaperone protein DnaK
HSP70
Heat shock 70 kDa protein
Heat shock protein 70
Gene Name: dnaK
|
| UniProt ID | P0A3J0 (DNAK_LACLA), Reviewed |
| GO terms | GO:0006457 protein folding
GO:0006950 response to stress
GO:0000166 nucleotide binding
GO:0005524 ATP binding
GO:0051082 unfolded protein binding |
| Organisms for which functions have been demonstrated | Lactococcus lactis IL1403 (Gram positive bacterium) |
| Sequence length | 607 |
| FASTA sequence | >gi|15672936|ref|NP_267110.1| molecular chaperone DnaK [Lactococcus lactis subsp. lactis Il1403]
MSKIIGIDLGTTNSAVAVLEGTESKIIPNPEGNRTTPSVVAFKNGEIIVGDAAKRQAVTNPETIISIKSKMGTSEKVSANGKEYTPQEISAMILQNLKATAEAYLGEKVEKAVITVPAYFNDAQRQATKDAGKIAGLEVERIVNEPTAAALAYGLDKTDKDEKILVFDLGGGTFDVSILELGDGVFDVLATAGNNKLGGDDFDQKIIDWMVAEFKKENGIDLAQDKMALQRLKDAAEKAKKDLSGVTTTQISLPFITAGAAGPLHLEMALTRAKFDELTHDLVEATRQPVRQALSDAGLSTSDIDEVLLVGGSTRIPAVVELVRHETNKEPNKSVNPDEVVAMGAAIQGGVITGDVKDVVLLDVTPLSLGIETMGGVFTKLIDRNTTIPTSKSQVFSTAADNQPAVDIHVLQGERPMAADNKTLGRFQLTDIPAAPRGIPQIEVTFDIDKNGIVSVKAKDLGTQKEQTIVIKSNSGLSDEEIDKMMKDAEANADADAKRKEEVDTRNEADALVFQTEKTLKDLEGKVEEAEVKKAEEAKEELKKALEGEDIDDIKAKSEALSEIAQNLAVKLYEQANAAQGEAGQATDAQEAPKDDNTFDGDFEESK |
| Structure Information |
| PDB ID | Closest homologue is 2V7Y_A (79.22%) |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-2,467-480,484-503, 524-529,574-607 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | chaperone |
| References for function | |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | binding to invertase, a hyperglycosylated mannoprotein from Saccharomyces cerevisiae |
| References for function | Katakura Y, Sano R, Hashimoto T, Ninomiya K, Shioya S. 2010. Lactic
acid bacteria display on the cell surface cytosolic proteins that recognize yeast mannan. Appl Microbiol Biotechnol. 2010 Mar;86(1):319-26. doi: 10.1007/s00253-009-2295-y. Epub 2009 Nov 7.PMID: 19898842 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cell surface, cell wall |
| Comments | part of a symbiotic relationship with yeast |