| General Information |
| MoonProt ID | 193 |
| First appeared in release | 1.0 |
| Name(s) | EF-G
Elongation factor G
Gene Name:fusA |
| UniProt ID | A8AUR6 (EFG_STRGC), Reviewed |
| GO terms | GO:0006184 GTP catabolic process
GO:0006412 translation
GO:0006414 translational elongation
GO:0000166 nucleotide binding
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0005622 intracellular
GO:0005737 cytoplasm |
| Organisms for which functions have been demonstrated | Streptococcus gordonii (Gram positive bacterium) |
| Sequence length | 693 |
| FASTA sequence | >sp|A8AUR6|EFG_STRGC Elongation factor G OS=Streptococcus gordonii (strain Challis / ATCC 35105 / CH1 / DL1 / V288) GN=fusA PE=3 SV=1
MAREFSLEKTRNIGIMAHVDAGKTTTTERILYYTGKIHKIGETHEGASQMDWMEQEQERGITITSAATTAQWNNHRVNIIDTPGHVDFTIEVQRSLRVLDGAVTVLDSQSGVEPQTETVWRQATEYGVPRIVFANKMDKIGADFLYSVSTLHDRLQANAHPIQLPIGAEDDFRGIIDLIKMKAEIYTNDLGTDILEEDIPAEYLEQAQEYREKLVEAVAETDEDLMMKYLEGEEITNEELKAGIRKATINVEFFPVLCGSAFKNKGVQLMLDAVIDYLPSPLDIPAIKGINPDTDEEETRPASDEEPFAALAFKIMTDPFVGRLTFFRVYSGVLQSGSYVLNTSKGKRERIGRILQMHANSRQEIETVYAGDIAAAVGLKDTTTGDSLTDEKAKIILESINVPEPVIQLMVEPKSKADQDKMGVALQKLAEEDPTFRVETNVETGETVISGMGELHLDVLVDRMRREFKVEANVGAPQVSYRETFRASTQARGFFKRQSGGKGQFGDVWIEFTPNEEGKGFEFENAIVGGVVPREFIPAVEKGLVESMANGVLAGYPIVDVKAKLYDGSYHDVDSSETAFKVAASLALKEAAKTAQPAILEPMMLVTITVPEENLGDVMGHVTARRGRVDGMEAHGNSQIVRAYVPLAEMFGYATVLRSASQGRGTFMMVFDHYEDVPKSVQEEIIKKHKGEA |
| Structure Information |
| PDB ID | Closest homologue in PDB is from Staphylococcus aureus with 76.05% amino acid sequence identity; 99% query cover |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1 to 4, 6, 291-303, 632-637, 686-693 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | elongation factor in translation
catalyzes translocation step, uses GTP |
| References for function | |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm, on ribosome |
| Comments | |
| Function 2 |
| Function description | adhesin, binds salivary mucin MUC7 |
| References for function | Kesimer M, Kili? N, Mehrotra R, Thornton DJ, Sheehan JK. Identification of salivary mucin MUC7 binding proteins from Streptococcus gordonii. BMC Microbiol. 2009 Aug 11. PMID: 19671172 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |