General Information |
MoonProt ID | 196 |
First appeared in release | 1.0 |
Name(s) | D-fructose 1,6-bisphosphate aldolase/phosphatase
Fructose-1,6-bisphosphatase
Gene Name:fbp |
UniProt ID | F9VMT6 (F9VMT6_SULTO), Unreviewed |
GO terms | GO:0008152 metabolic process
GO:0016311 dephosphorylation
GO:0016787 hydrolase activity
GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity
GO:0046872 metal ion binding |
Organisms for which functions have been demonstrated | Sulfolobus tokodaii |
Sequence length | 384 |
FASTA sequence | >sp|F9VMT6|FBPAP_SULTO Fructose-1,6-bisphosphate aldolase/phosphatase OS=Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) GN=fbp PE=1 SV=1
MKTTISVIKADIGSLAGHHIVHPDTMAAANKVLASAKEQGIILDYYITHVGDDLQLIMTHTRGELDTKVHETAWNAFKEAAKVAKDLGLYAAGQDLLSDSFSGNVRGLGPGVAEMEIEERASEPIAIFMADKTEPGAYNLPLYKMFADPFNTPGLVIDPTMHGGFKFEVLDVYQGEAVMLSAPQEIYDLLALIGTPARYVIRRVYRNEDNLLAAVVSIERLNLIAGKYVGKDDPVMIVRLQHGLPALGEALEAFAFPHLVPGWMRGSHYGPLMPVSQRDAKATRFDGPPRLLGLGFNVKNGRLVGPTDLFDDPAFDETRRLANIVADYMRRHGPFMPHRLEPTEMEYTTLPLILEKLKDRFKKESDVYKAKESIYAKEESQGHD |
Structure Information |
PDB ID | 1UMG,
2QUT, |
Quaternary structure | |
SCOP | Sulfolobus fructose-1,6-bisphosphatase-like |
CATH | NA |
TM Helix Prediction | no TM helices |
DisProt Annotation | Not in DisProt |
Predicted Disorder Regions | 1-3, 368-384 |
Connections to Disease |
OMIM ID | |
Function 1 |
Function description | fructose-1,6-bisphosphatase, enzyme
dephosphorylation of FBP to fructose-6-phosphate |
References for function | Fushinobu S, Nishimasu H, Hattori D, Song HJ, Wakagi T. Structural basis for the bifunctionality of fructose-1,6-bisphosphate aldolase/phosphatase. Nature. 2011 Oct 9. PMID: 21983966 |
E.C. number | 3.1.3.11 |
Location of functional site(s) | |
Cellular location of function | cytoplasm |
Comments | Note - both functions in same active site |
Function 2 |
Function description | fructose-1,6-bisphosphate aldolase, enzyme
reversible aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to FBP |
References for function | Fushinobu S, Nishimasu H, Hattori D, Song HJ, Wakagi T. Structural basis for the bifunctionality of fructose-1,6-bisphosphate aldolase/phosphatase. Nature. 2011 Oct 9. PMID: 21983966 |
E.C. number | 4.1.2.13 |
Location of functional site(s) | |
Cellular location of function | cytoplasm |
Comments | Note - both functions in same active site |