| General Information |
| MoonProt ID | 196 |
| First appeared in release | 1.0 |
| Name(s) | D-fructose 1,6-bisphosphate aldolase/phosphatase
Fructose-1,6-bisphosphatase
Gene Name:fbp |
| UniProt ID | F9VMT6 (F9VMT6_SULTO), Unreviewed |
| GO terms | GO:0008152 metabolic process
GO:0016311 dephosphorylation
GO:0016787 hydrolase activity
GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity
GO:0046872 metal ion binding |
| Organisms for which functions have been demonstrated | Sulfolobus tokodaii |
| Sequence length | 384 |
| FASTA sequence | >sp|F9VMT6|FBPAP_SULTO Fructose-1,6-bisphosphate aldolase/phosphatase OS=Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) GN=fbp PE=1 SV=1
MKTTISVIKADIGSLAGHHIVHPDTMAAANKVLASAKEQGIILDYYITHVGDDLQLIMTHTRGELDTKVHETAWNAFKEAAKVAKDLGLYAAGQDLLSDSFSGNVRGLGPGVAEMEIEERASEPIAIFMADKTEPGAYNLPLYKMFADPFNTPGLVIDPTMHGGFKFEVLDVYQGEAVMLSAPQEIYDLLALIGTPARYVIRRVYRNEDNLLAAVVSIERLNLIAGKYVGKDDPVMIVRLQHGLPALGEALEAFAFPHLVPGWMRGSHYGPLMPVSQRDAKATRFDGPPRLLGLGFNVKNGRLVGPTDLFDDPAFDETRRLANIVADYMRRHGPFMPHRLEPTEMEYTTLPLILEKLKDRFKKESDVYKAKESIYAKEESQGHD |
| Structure Information |
| PDB ID | 1UMG,
2QUT, |
| Quaternary structure | |
| SCOP | Sulfolobus fructose-1,6-bisphosphatase-like |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-3, 368-384 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | fructose-1,6-bisphosphatase, enzyme
dephosphorylation of FBP to fructose-6-phosphate |
| References for function | Fushinobu S, Nishimasu H, Hattori D, Song HJ, Wakagi T. Structural basis for the bifunctionality of fructose-1,6-bisphosphate aldolase/phosphatase. Nature. 2011 Oct 9. PMID: 21983966 |
| E.C. number | 3.1.3.11 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | Note - both functions in same active site |
| Function 2 |
| Function description | fructose-1,6-bisphosphate aldolase, enzyme
reversible aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to FBP |
| References for function | Fushinobu S, Nishimasu H, Hattori D, Song HJ, Wakagi T. Structural basis for the bifunctionality of fructose-1,6-bisphosphate aldolase/phosphatase. Nature. 2011 Oct 9. PMID: 21983966 |
| E.C. number | 4.1.2.13 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | Note - both functions in same active site |