| General Information |
| MoonProt ID | 2 |
| First appeared in release | 1.0 |
| Name(s) | Transcription antitermination protein RfaH
Gene Name:rfaH |
| UniProt ID | P0AFW0 (RFAH_ECOLI), Reviewed |
| GO terms | GO:0001124 transcription elongation from bacterial-type RNA polymerase promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0031564 transcription antitermination
GO:0045727 positive regulation of translation
GO:0001000 bacterial-type RNA polymerase core enzyme binding GO:0001073 DNA binding transcription antitermination factor activity
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008494 translation activator activity |
| Organisms for which functions have been demonstrated | Escherichia coli (Gram negative bacterium) |
| Sequence length | 162 |
| FASTA sequence | >sp|P0AFW0|RFAH_ECOLI Transcription antitermination protein RfaH OS=Escherichia coli (strain K12) GN=rfaH PE=1 SV=1
MQSWYLLYCKRGQLQRAQEHLERQAVNCLAPMITLEKIVRGKRTAVSEPLFPNYLFVEFDPEVIHTTTINATRGVSHFVRFGASPAIVPSAVIHQLSVYKPKDIVDPATPYPGDKVIITEGAFEGFQAIFTEPDGEARSMLLLNLINKEIKHSVKNTEFRKL
|
| Structure Information |
| PDB ID | 2OUG,
2LCL |
| Quaternary structure | |
| SCOP | NA |
| CATH | 3.30.70.940 |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1, 159-162 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | aids in transcription elongation of long RNA chains,
reduces pausing and inhibits termination
|
| References for function | |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | bound to DNA |
| Comments | |
| Function 2 |
| Function description | translational regulator |
| References for function | Burmann BM, Knauer SH, Sevostyanova A, Schweimer K, Mooney RA, Landick R, Artsimovitch I, R?sch P. An a helix to ? barrel domain switch transforms the transcription factor RfaH into a translation factor. Cell. 2012 Jul 20. PMID: 22817892 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |