| General Information |
| MoonProt ID | 210 |
| First appeared in release | 1.0 |
| Name(s) | PTS system glucose-specific EIICB component
EIICB-Glc
EII-Glc
Glucose permease IIC component
PTS system glucose-specific EIIC component
Glucose-specific phosphotransferase enzyme IIB component
PTS system glucose-specific EIIB component
Gene Name:ptsG |
| UniProt ID | P69786 (PTGCB_ECOLI), Reviewed |
| GO terms | GO:0006810 transport
GO:0008643 carbohydrate transport
GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system
GO:0015758 glucose transport
GO:0015992 proton transport
GO:0016310 phosphorylation
GO:0034219 carbohydrate transmembrane transport
GO:0005351 sugar:hydrogen symporter activity
GO:0005355 glucose transmembrane transporter activity
GO:0008982 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane |
| Organisms for which functions have been demonstrated | Escherichia coli (Gram negative bacterium) |
| Sequence length | 477 |
| FASTA sequence | >sp|P69786|PTGCB_ECOLI PTS system glucose-specific EIICB component OS=Escherichia coli (strain K12) GN=ptsG PE=1 SV=1
MFKNAFANLQKVGKSLMLPVSVLPIAGILLGVGSANFSWLPAVVSHVMAEAGGSVFANMPLIFAIGVALGFTNNDGVSALAAVVAYGIMVKTMAVVAPLVLHLPAEEIASKHLADTGVLGGIISGAIAAYMFNRFYRIKLPEYLGFFAGKRFVPIISGLAAIFTGVVLSFIWPPIGSAIQTFSQWAAYQNPVVAFGIYGFIERCLVPFGLHHIWNVPFQMQIGEYTNAAGQVFHGDIPRYMAGDPTAGKLSGGFLFKMYGLPAAAIAIWHSAKPENRAKVGGIMISAALTSFLTGITEPIEFSFMFVAPILYIIHAILAGLAFPICILLGMRDGTSFSHGLIDFIVLSGNSSKLWLFPIVGIGYAIVYYTIFRVLIKALDLKTPGREDATEDAKATGTSEMAPALVAAFGGKENITNLDACITRLRVSVADVSKVDQAGLKKLGAAGVVVAGSGVQAIFGTKSDNLKTEMDEYIRNH
|
| Structure Information |
| PDB ID | 1IBA |
| Quaternary structure | |
| SCOP | Homing endonuclease-like |
| CATH | 3.30.1360.60 |
| TM Helix Prediction | 10(21-43,53-72,79-101,116-133,154-176,191-213,250-272,282-304,309-331,354-376) |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-3, 388-397, 474-477 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | phosphorylates glucose, enzyme
sugars are phosphorylated during transport through the channel subunit of the protein complex
|
| References for function | |
| E.C. number | 2.7.1.69 |
| Location of functional site(s) | |
| Cellular location of function | integral membrane protein, plasma membrane |
| Comments | |
| Function 2 |
| Function description | IIB subunit binds and sequesters Mlc transcription repressor in presence of glucose |
| References for function | Tanaka Y, Kimata K, Aiba H. A novel regulatory role of glucose transporter of Escherichia coli: membrane sequestration of a global repressor Mlc. EMBO J. 2000 Oct 16. PMID: 11032802 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | plasma membrane, integral membrane protein |
| Comments | |