| General Information |
| MoonProt ID | 214 |
| First appeared in release | 4.0 |
| Name(s) | Vacuolar protein sorting-associated protein 72 homolog |
| UniProt ID | Q15906 |
| GO terms | "GO:0035019 somatic stem cell population maintenance
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0042393 histone binding
GO:0042393 histone binding
GO:0140713 histone chaperone activity
GO:0140713 histone chaperone activity
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0006325 chromatin organization
GO:0006338 chromatin remodeling
GO:0006338 chromatin remodeling
GO:0006355 regulation of DNA-templated transcription
GO:0042981 regulation of apoptotic process
GO:0045815 transcription initiation-coupled chromatin remodeling
GO:0045893 positive regulation of DNA-templated transcription
GO:0051726 regulation of cell cycle
GO:1905168 positive regulation of double-strand break repair via homologous recombination
GO:2000779 regulation of double-strand break repair
GO:0005634 nucleus
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016607 nuclear speck
GO:0000786 nucleosome
GO:0000786 nucleosome
GO:0000812 Swr1 complex
GO:0032991 protein-containing complex
GO:0035267 NuA4 histone acetyltransferase complex" |
| Organisms for which functions have been demonstrated | "
Homo sapiens (Human)" |
| Sequence length | 364.0 |
| FASTA sequence | >sp|Q15906|VPS72_HUMAN Vacuolar protein sorting-associated protein 72 homolog OS=Homo sapiens OX=9606 GN=VPS72 PE=1 SV=1 MSLAGGRAPRKTAGNRLSGLLEAEEEDEFYQTTYGGFTEESGDDEYQGDQSDTEDEVDSD FDIDEGDEPSSDGEAEEPRRKRRVVTKAYKEPLKSLRPRKVNTPAGSSQKAREEKALLPL ELQDDGSDSRKSMRQSTAEHTRQTFLRVQERQGQSRRRKGPHCERPLTQEELLREAKITE ELNLRSLETYERLEADKKKQVHKKRKCPGPIITYHSVTVPLVGEPGPKEENVDIEGLDPA PSVSALTPHAGTGPVNPPARCSRTFITFSDDATFEEWFPQGRPPKVPVREVCPVTHRPAL YRDPVTDIPYATARAFKIIREAYKKYITAHGLPPTASALGPGPPPPEPLPGSGPRALRQK IVIK |
| Structure Information |
| PDB ID | 5FUG |
| Quaternary structure | Component of the NuA4 histone acetyltransferase complex |
| SCOP | "80475535FUG L:9-65
80931475FUG L:9-65" |
| CATH | 1.10.20.10 |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | not in Disprot |
| Predicted Disorder Regions | Predicted disorder at N terminus (aa 1-169), middle region (aa 221-258), and C terminus (aa 335-364) |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | component of SRCAP and p400/Tip60 chromatin remodeling complexes |
| References for function | Messina G, Prozzillo Y, Monache FD, Santopietro MV, Dimitri P. Evolutionary conserved relocation of chromatin remodeling complexes to the mitotic apparatus. BMC Biol. 2022 Aug 3;20(1):172. doi: 10.1186/s12915-022-01365-5. PMID: 35922843; PMCID: PMC9351137. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | chromatin |
| Comments | |
| Function 2 |
| Function description | localizes to mitotic spindle and midbody during cell division |
| References for function | Messina G, Prozzillo Y, Monache FD, Santopietro MV, Dimitri P. Evolutionary conserved relocation of chromatin remodeling complexes to the mitotic apparatus. BMC Biol. 2022 Aug 3;20(1):172. doi: 10.1186/s12915-022-01365-5. PMID: 35922843; PMCID: PMC9351137. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | mitotic apparatus |
| Comments | |