| General Information |
| MoonProt ID | 226 |
| First appeared in release | 1.0 |
| Name(s) | Mevalonate kinase
MK
cytosolic luteinizing hormone binding protein
LHBP-1
Gene Name:Mvk |
| UniProt ID | P17256 (KIME_RAT), Reviewed |
| GO terms | GO:0006629 lipid metabolic process
GO:0006694 steroid biosynthetic process
GO:0006695 cholesterol biosynthetic process
GO:0006720 isoprenoid metabolic process
GO:0008152 metabolic process
GO:0008202 steroid metabolic process
GO:0008203 cholesterol metabolic process
GO:0008299 isoprenoid biosynthetic process
GO:0016125 sterol metabolic process
GO:0016126 sterol biosynthetic process
GO:0016310 phosphorylation
GO:0017148 negative regulation of translation
GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway
GO:0045540 regulation of cholesterol biosynthetic process
GO:0000166 nucleotide binding
GO:0003729 mRNA binding
GO:0004496 mevalonate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0005737 cytoplasm
GO:0005777 peroxisome
GO:0005829 cytosol
|
| Organisms for which functions have been demonstrated | Rattus norvegicus (rat, a mammal) |
| Sequence length | 395 |
| FASTA sequence | >sp|P17256|KIME_RAT Mevalonate kinase OS=Rattus norvegicus GN=Mvk PE=1 SV=1
MLSEVLLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLVLRPQSNGKVSLNLPNVGIKQVWDVATLQLLDTGFLEQGDVPAPTLEQLEKLKKVAGLPRDCVGNEGLSLLAFLYLYLAICRKQRTLPSLDIMVWSELPPGAGLGSSAAYSVCVAAALLTACEEVTNPLKDRGSIGSWPEEDLKSINKWAYEGERVIHGNPSGVDNSVSTWGGALRYQQGKMSSLKRLPALQILLTNTKVPRSTKALVAGVRSRLIKFPEIMAPLLTSIDAISLECERVLGEMAAAPVPEQYLVLEELMDMNQHHLNALGVGHASLDQLCQVTAAHGLHSKLTGAGGGGCGITLLKPGLERAKVEAAKQALTGCGFDCWETSIGAPGVSMHSATSIEDPVRQALGL
|
| Structure Information |
| PDB ID | 1KVK
2R42 |
| Quaternary structure | |
| SCOP | Ribosomal protein S5 domain 2-like, Ferredoxin-like |
| CATH | 3.30.230.10, 3.30.70.890 |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-5, 170-174, 386-395 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | Mevalonate kinase, enzyme
ATP + (R)-mevalonate => ADP + (R)-5-phosphomevalonate
Isoprenoid biosynthesis, mevalonate pathway |
| References for function | |
| E.C. number | 2.7.1.36 |
| Location of functional site(s) | |
| Cellular location of function | peroxisome |
| Comments | |
| Function 2 |
| Function description | mRNA binding
cytosolic luteinizing hormone receptor mRNA binding protein
increases LH receptor mRNA degradation |
| References for function | Nair AK, Kash JC, Peegel H, Menon KM. Post-transcriptional regulation of luteinizing hormone receptor mRNA in the ovary by a novel mRNA-binding protein. J Biol Chem. 2002 Jun 14. PMID: 11940568.
Kash JC, Menon KM. Sequence-specific binding of a hormonally regulated mRNA binding protein to cytidine-rich sequences in the lutropin receptor open reading frame. Biochemistry. 1999 Dec 21. PMID: 10606523.
Kash JC, Menon KM. Identification of a hormonally regulated luteinizing hormone/human chorionic gonadotropin receptor mRNA binding protein. Increased mrna binding during receptor down-regulation. J Biol Chem. 1998 Apr 24. PMID: 9553128. |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |